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A New Blood Glucose Control Scheme for Unannounced Exercise in Type 1 Diabetic Subjects

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A New Blood Glucose Control Scheme for Unannounced Exercise in Type 1 Diabetic Subjects

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dc.contributor.author Beneyto, Aleix es_ES
dc.contributor.author Bertachi, Arthur es_ES
dc.contributor.author Bondía Company, Jorge es_ES
dc.contributor.author Vehí, Josep es_ES
dc.date.accessioned 2020-04-17T12:48:37Z
dc.date.available 2020-04-17T12:48:37Z
dc.date.issued 2020-03 es_ES
dc.identifier.issn 1063-6536 es_ES
dc.identifier.uri http://hdl.handle.net/10251/140854
dc.description.abstract [EN] The artificial pancreas (AP) system or closed-loop blood glucose (BG) regulation is a technological advancement that aims to relieve diabetic subjects from their current decision-making burden while tightening their BG levels. However, large disturbances such as meals and exercise still pose great challenges to a fully closed-loop system. In this paper, the problem of BG regulation with unannounced physical activity for type 1 diabetic subjects is addressed. We use a coordinated control strategy with insulin infusion and extra carbohydrates (CHO) for hypoglycemia avoidance. The insulin algorithm is based on a proportional-derivative controller with insulin feedback and the so-called safety auxiliary feedback element (SAFE) layer, and the algorithm for CHO is based on a predictive, quantified proportional-derivative controller. The UVa/Padua simulator glucose-insulin model is modified to include the effects of physical activity and is used to test the new AP. We consider scenarios where the subject does not announce physical activity and with challenging meals. Then, we analyze the performance and robustness of the combined insulin and CHO recommender system and compare them to the insulin-only controller. The simulation results show that the new AP system is able to mitigate daily hypoglycemia episodes (0.9 versus 0.2, p < 0.01) and increase the time in range during day (91.5% versus 92.4%, p < 0.01) without increasing the time above 180 mg/dl (6.3% versus 6.4%, p > 0.05). es_ES
dc.description.sponsorship This work was supported in part by the Ministerio de Economia, Industria y Competitividad under Grant DPI2016-78831-C2-1-R and Grant DPI2016-78831-C2-2-R, in part by the Autonomous Government of Catalonia under Grant 2017 SGR 1551, in part by the Ministerio de Educacion, Cultura y Deporte under Grant FPU0244 2015, in part by the National Counsel of Technological and Scientific Development, CNPq, Brazil, under Grant 207688/2014-1, and in part EU through FEDER funds. Recommended by Associate Editor D. E. Rivera. es_ES
dc.language Inglés es_ES
dc.publisher Institute of Electrical and Electronics Engineers es_ES
dc.relation MINECO/DPI2016-78831-C2-2-R es_ES
dc.relation GC/2017 SGR 1551 es_ES
dc.relation MECD/FPU0244 2015 es_ES
dc.relation CNPq/207688/2014-1 es_ES
dc.relation AEI/DPI2016-78831-C2-1-R es_ES
dc.relation.ispartof IEEE Transactions on Control Systems Technology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Artificial pancreas es_ES
dc.subject Blood glucose (BG) control es_ES
dc.subject Carbohydrates (CHO) es_ES
dc.subject Insulin es_ES
dc.subject Physical activity es_ES
dc.subject Proportional derivative (PD) es_ES
dc.subject Recursive least squares es_ES
dc.subject Sliding mode reference conditioning (SMRC) es_ES
dc.subject Type 1 diabetes es_ES
dc.subject.classification INGENIERIA DE SISTEMAS Y AUTOMATICA es_ES
dc.title A New Blood Glucose Control Scheme for Unannounced Exercise in Type 1 Diabetic Subjects es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1109/TCST.2018.2878205 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica es_ES
dc.description.bibliographicCitation Beneyto, A.; Bertachi, A.; Bondía Company, J.; Vehí, J. (2020). A New Blood Glucose Control Scheme for Unannounced Exercise in Type 1 Diabetic Subjects. IEEE Transactions on Control Systems Technology. 28(2):593-600. https://doi.org/10.1109/TCST.2018.2878205 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1109/TCST.2018.2878205 es_ES
dc.description.upvformatpinicio 593 es_ES
dc.description.upvformatpfin 600 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 28 es_ES
dc.description.issue 2 es_ES
dc.relation.pasarela S\386330 es_ES
dc.contributor.funder Generalitat de Catalunya es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES
dc.contributor.funder Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brasil es_ES


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