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Fluoride-induced modulation of ionic transport in asymmetric nanopores functionalized with "caged" fluorescein moieties

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Fluoride-induced modulation of ionic transport in asymmetric nanopores functionalized with "caged" fluorescein moieties

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dc.contributor.author Ali, Mubarak es_ES
dc.contributor.author Ahmed, Ishtiaq es_ES
dc.contributor.author Ramirez Hoyos, Patricio es_ES
dc.contributor.author Nasir, Saima es_ES
dc.contributor.author Cervera, Javier es_ES
dc.contributor.author Niemeyer, Christof M. es_ES
dc.contributor.author Ensinger, Wolfgang es_ES
dc.date.accessioned 2020-04-17T12:50:47Z
dc.date.available 2020-04-17T12:50:47Z
dc.date.issued 2016 es_ES
dc.identifier.issn 2040-3364 es_ES
dc.identifier.uri http://hdl.handle.net/10251/140929
dc.description.abstract [EN] We demonstrate experimentally and theoretically a nanofluidic fluoride sensing device based on a single conical pore functionalized with "caged" fluorescein moieties. The nanopore functionalization is based on an amine-terminated fluorescein whose phenolic hydroxyl groups are protected with tert-butyldiphenylsilyl (TBDPS) moieties. The protected fluorescein (Fcn-TBDPS-NH2) molecules are then immobilized on the nanopore surface via carbodiimide coupling chemistry. Exposure to fluoride ions removes the uncharged TBDPS moieties due to the fluoride-promoted cleavage of the silicon-oxygen bond, leading to the generation of negatively charged groups on the fluorescein moieties immobilized onto the pore surface. The asymmetrical distribution of these groups along the conical nanopore leads to the electrical rectification observed in the current-voltage (I-V) curve. On the contrary, other halides and anions are not able to induce any significant ionic rectification in the asymmetric pore. In each case, the success of the chemical functionalization and deprotection reactions is monitored through the changes observed in the I-V curves before and after the specified reaction step. The theoretical results based on the Nernst-Planck and Poisson equations further demonstrate the validity of an experimental approach to fluoride-induced modulation of nanopore current rectification behaviour. es_ES
dc.description.sponsorship M. A., S. N. and W. E. acknowledge the funding from the Hessen State Ministry of Higher Education, Research and the Arts, Germany, under the LOEWE project iNAPO. P. R. and J. C. acknowledge financial support by the Generalitat Valenciana (Program of Excellence Prometeo/GV/0069), the Spanish Ministry of Economic Affairs and Competitiveness (MAT2015-65011-P), and FEDER. I. A. and C. M. N. acknowledge the financial support through the Helmholtz programme BioInterfaces in Technology and Medicine. The authors are thankful to Prof. Salvador Mafe (Universitat de Valencia, Spain) for fruitful discussion and to Prof. Christina Trautmann from GSI (Department of Material Research) for support with the heavy ion irradiation experiments. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Nanoscale es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Fluoride-induced modulation of ionic transport in asymmetric nanopores functionalized with "caged" fluorescein moieties es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c6nr00292g es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-65011-P/ES/NANOFLUIDICA DE POROS BIOMIMETICOS: NUEVAS APLICACIONES EN CONVERSION DE ENERGIA Y SENSORES%2FACTUADORES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2FGV%2F0069 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Ali, M.; Ahmed, I.; Ramirez Hoyos, P.; Nasir, S.; Cervera, J.; Niemeyer, CM.; Ensinger, W. (2016). Fluoride-induced modulation of ionic transport in asymmetric nanopores functionalized with "caged" fluorescein moieties. Nanoscale. 8(16):8583-8590. https://doi.org/10.1039/c6nr00292g es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c6nr00292g es_ES
dc.description.upvformatpinicio 8583 es_ES
dc.description.upvformatpfin 8590 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 8 es_ES
dc.description.issue 16 es_ES
dc.relation.pasarela S\314419 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES
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