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Antimicrobial activity of commercial calcium phosphate based materials functionalized with vanillin

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Antimicrobial activity of commercial calcium phosphate based materials functionalized with vanillin

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dc.contributor.author Polo, Lorena es_ES
dc.contributor.author Díaz de Greñu-Puertas, Borja es_ES
dc.contributor.author Della Bella, Elena es_ES
dc.contributor.author Pagani, Stefania es_ES
dc.contributor.author Torricelli, Paola es_ES
dc.contributor.author Vivancos, José-Luis es_ES
dc.contributor.author Ruiz Rico, María es_ES
dc.contributor.author Barat Baviera, José Manuel es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Fini, Milena es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.date.accessioned 2020-05-14T03:05:05Z
dc.date.available 2020-05-14T03:05:05Z
dc.date.issued 2018-11 es_ES
dc.identifier.issn 1742-7061 es_ES
dc.identifier.uri http://hdl.handle.net/10251/143141
dc.description.abstract [EN] Infections represent one of the most frequent causes of arthroplasty revision. Thus, design of new antimi-crobial scaffolds to reduce implant rejections, bone infections and associated medical costs is highlydesired. In recent years, essential oil components (EOCs) have merged as compounds with signi¿cantantimicrobial activity that can be attached to speci¿c surfaces to enhance and prolong their antimicrobialeffect. Herein calcium phosphate CaP regenerative materials have been coated with a vanillin derivativeto combine its original bone regeneration properties with antimicrobial action of EOCs. Materials in formof microparticles and blocks were prepared and fully characterized. Clonogenic viability tests demon-strated that low concentrations of material (10 mg/mL-1) resulted effective to kill 100% of E. coli DH5abacteria. Additionally, vanillin containing scaffolds did not display any toxic effect over cells, yet theypreserve the ability to express alkaline phosphatase (ALPL), collagen type 1, chaina1(COL1A1) and bonegamma-carboxyglutamic acid-containing protein or osteocalcin (BGLAP), which are genes typicallyexpressed by osteoblasts. These results demonstrate that commercially available scaffolds can be func-tionalized with EOCs, achieving antimicrobial activity and open up a new approach for the treatmentand prevention of infection. es_ES
dc.description.sponsorship The authors thank the Spanish Government, Spain for projects MAT2015-64139-C04-01-R (MINECO/FEDER). Also, Generalitat Valenciana, Spain (project PROMETEOII/2014/047) is acknowledged for their support. L. P. thanks Universitat Politecnica de Valencia, Spain for her FPI and mobility grants. B.D. thanks to Ministerio de Economia, Ciencia y Competitividad, Spain for his Juan de la Cierva-Formation fellowship. The authors also thank the Electron Microscopy Service at the UPV for their support. The authors are grateful to IRCCS Rizzoli Orthopaedic Institute, Italy (funds 5 X 1000 year 2015, cod. 6879). es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Acta Biomaterialia es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Biomaterials es_ES
dc.subject Antimicrobial es_ES
dc.subject Essential oils es_ES
dc.subject Vanillin es_ES
dc.subject.classification TECNOLOGIA DE ALIMENTOS es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification PROYECTOS DE INGENIERIA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Antimicrobial activity of commercial calcium phosphate based materials functionalized with vanillin es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.actbio.2018.09.033 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/IOR//6879/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Proyectos de Ingeniería - Departament de Projectes d'Enginyeria es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Tecnología de Alimentos - Departament de Tecnologia d'Aliments es_ES
dc.description.bibliographicCitation Polo, L.; Díaz De Greñu-Puertas, B.; Della Bella, E.; Pagani, S.; Torricelli, P.; Vivancos, J.; Ruiz Rico, M.... (2018). Antimicrobial activity of commercial calcium phosphate based materials functionalized with vanillin. Acta Biomaterialia. 81:293-303. https://doi.org/10.1016/j.actbio.2018.09.033 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.actbio.2018.09.033 es_ES
dc.description.upvformatpinicio 293 es_ES
dc.description.upvformatpfin 303 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 81 es_ES
dc.identifier.pmid 30273745 es_ES
dc.relation.pasarela S\373416 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Istituto Ortopedico Rizzoli, Italia es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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