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Mesoporous silica microparticles gated with a bulky azo derivative for the controlled release of dyes/ drugs in colon

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Mesoporous silica microparticles gated with a bulky azo derivative for the controlled release of dyes/ drugs in colon

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dc.contributor.author Ferri, Daniel es_ES
dc.contributor.author Gaviña, Pablo es_ES
dc.contributor.author Parra Álvarez, Margarita es_ES
dc.contributor.author Costero, Ana M. es_ES
dc.contributor.author El Haskouri, Jamal es_ES
dc.contributor.author Amorós del Toro, Pedro es_ES
dc.contributor.author Merino Sanjuán, Virginia es_ES
dc.contributor.author Teruel, Adrián H es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2020-05-15T03:02:59Z
dc.date.available 2020-05-15T03:02:59Z
dc.date.issued 2018-08 es_ES
dc.identifier.uri http://hdl.handle.net/10251/143317
dc.description.abstract [EN] Mesoporous silica microparticles were prepared, loaded with the dye safranin O (M-Saf) or with the drug budesonide (M-Bud) and capped by the grafting of a bulky azo derivative. Cargo release from M-Saf at different pH values (mimicking those found in the gastrointestinal tract) in the absence or presence of sodium dithionite (a reducing agent mimicking azoreductase enzyme present in the colon) was tested. Negligible safranin O release was observed at pH 6.8 and 4.5, whereas a moderate delivery at pH 1.2 was noted and attributed to the hydrolysis of the urea bond that linked the azo derivative onto the external surface of the inorganic scaffold. Moreover, a marked release was observed when sodium dithionite was present and was ascribed to the rupture of the azo bond in the molecular gate. Budesonide release from M-Bud in the presence of sodium dithionite was also assessed by ultraviolet-visible spectroscopy and high performance liquid chromatography measurements. In addition, preliminary in vivo experiments with M-Saf carried out in mice indicated that the chemical integrity of the microparticles remained unaltered in the stomach and the small intestine, and safranin O seemed to be released in the colon. es_ES
dc.description.sponsorship We thank the Spanish Government (projects MAT2015-64139-C4-4-R, MAT2015-64139-C4-2-R and MAT2015-64139-C4-1-R) and Generalitat Valenciana (project PROMETEOII/2014/047 and project AICO/2017/093) for financial support. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society es_ES
dc.relation MICINN/MAT2015-64139-C4-1-R es_ES
dc.relation GV/AICO/2017/093 es_ES
dc.relation MINISTERIO DE ECONOMIA Y COMPETITIVIDAD/MAT2015-64139-C4-4-R es_ES
dc.relation MINECO/ MAT2015-64139-C4-2-R es_ES
dc.relation GENERALITAT VALENCIANA/PROMETEOII/2014/047 es_ES
dc.relation.ispartof Royal Society Open Science es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Mesoporous silica microparticles es_ES
dc.subject Gated materials es_ES
dc.subject Controlled drug release es_ES
dc.subject Colon targeting es_ES
dc.subject Inflammatory bowel disease es_ES
dc.subject Budesonide es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Mesoporous silica microparticles gated with a bulky azo derivative for the controlled release of dyes/ drugs in colon es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1098/rsos.180873 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Ferri, D.; Gaviña, P.; Parra Álvarez, M.; Costero, AM.; El Haskouri, J.; Amorós Del Toro, P.; Merino Sanjuán, V.... (2018). Mesoporous silica microparticles gated with a bulky azo derivative for the controlled release of dyes/ drugs in colon. Royal Society Open Science. 5(8). https://doi.org/10.1098/rsos.180873 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1098/rsos.180873 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.description.issue 8 es_ES
dc.identifier.eissn 2054-5703 es_ES
dc.identifier.pmid 30225077 es_ES
dc.identifier.pmcid PMC6124098 es_ES
dc.relation.pasarela S\373871 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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