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Opportunistic screening for osteoporosis by routine CT in Southern Europe

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Opportunistic screening for osteoporosis by routine CT in Southern Europe

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dc.contributor.author Alacreu-Samper, Elena es_ES
dc.contributor.author Moratal, David es_ES
dc.contributor.author Arana Fernandez DE Moya, Estanislao es_ES
dc.date.accessioned 2020-05-15T03:03:00Z
dc.date.available 2020-05-15T03:03:00Z
dc.date.issued 2017-03 es_ES
dc.identifier.issn 0937-941X es_ES
dc.identifier.uri http://hdl.handle.net/10251/143318
dc.description.abstract [EN] Feasibility evaluation of early detection of osteoporosis in oncologic patients by bone mineral density (BMD) on abdominal computed tomography (CT) scans performed for other clinical indications, by using dual-energy X-ray absorptiometry (DXA) as reference. Abdominal CT images can identify patients with osteoporosis BMD without additional radiation exposure or cost. The purpose of the study is to evaluate the feasibility of early detection of osteoporosis by bone mineral density (BMD) on abdominal computed tomography (CT) scans performed in oncologic patients, comparing calibrated and uncalibrated measurements by using dual-energy X-ray absorptiometry (DXA) as reference. We also performed an external validation of a threshold of 160 Hounsfield units (HU), proposed as highly sensitive. Cohort comprised CT-DXA pairs within a 6-month period performed for any indication on 326 consecutive adults, aged 62.4 +/- 12.38 years (mean +/- standard deviation). CT attenuation of trabecular bone in HU was measured at the axial cross sections of L1, L2, L3, and L4 vertebrae. Vertebral compression fractures were assessed by sagittal reconstruction view. Diagnostic performance measures and the area under the receiver operator characteristic curve (AUC) for diagnosing osteoporosis were calculated. BMD values were statistical significantly lower at any vertebral level from L1 to L4 for patients with osteoporosis defined by DXA (p < 0.001). Calibrated and uncalibrated BMD values were significantly correlated (R (2) = 0.833, p < 0.01). An uncalibrated L1 CT attenuation threshold of 160 HU was more than 90 % sensitive, and a threshold of 73 HU was more than 90 % specific for distinguishing osteoporosis BMD. Fifty-nine percent of patients with vertebral compression fracture had non-osteoporotic DXA T-scores. Abdominal CT images obtained for other reasons can identify patients with osteoporosis BMD without additional radiation exposure or cost. Uncalibrated values at L1 can detect more osteoporosis patients with spinal compression fractures than DXA in oncologic patients. es_ES
dc.description.sponsorship This work was supported by the Spanish Ministerio de Economia y Competitividad (MINECO) and by FEDER funds under Grant TEC2012-33778 and BFU2015-64380-C2-2-R (D. Moratal). This work is part of the PhD student research work of E. Alacreu, which is financed by MINECO FPI. We acknowledge Dr. Francisco K Kovacs, for his insightful comments and reviews. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Osteoporosis International es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Bone density es_ES
dc.subject Computed tomography es_ES
dc.subject External validation es_ES
dc.subject Lumbar vertebrae es_ES
dc.subject Osteoporosis es_ES
dc.subject Screening es_ES
dc.subject Spinal fractures es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Opportunistic screening for osteoporosis by routine CT in Southern Europe es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00198-016-3804-3 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2012-33778/ES/CARACTERIZACION CUANTITATIVA DE LA METASTASIS VERTEBRAL MEDIANTE ANALISIS DE IMAGEN DE TC Y MODELADO POR ELEMENTOS FINITOS PARA LA DETERMINACION DEL RIESGO DE FRACTURA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2015-64380-C2-2-R/ES/ANALISIS DE TEXTURAS EN IMAGEN CEREBRAL MULTIMODAL POR RESONANCIA MAGNETICA PARA UNA DETECCION TEMPRANA DE ALTERACIONES EN LA RED Y BIOMARCADORES DE ENFERMEDAD/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Alacreu-Samper, E.; Moratal, D.; Arana Fernandez De Moya, E. (2017). Opportunistic screening for osteoporosis by routine CT in Southern Europe. Osteoporosis International. 28(3):983-990. https://doi.org/10.1007/s00198-016-3804-3 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s00198-016-3804-3 es_ES
dc.description.upvformatpinicio 983 es_ES
dc.description.upvformatpfin 990 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 28 es_ES
dc.description.issue 3 es_ES
dc.identifier.pmid 28108802 es_ES
dc.relation.pasarela S\342787 es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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