Llopis-Lorente, A.; De Luis-Fernández, B.; García-Fernández, A.; Jiménez-Falcao, S.; Orzaez, M.; Sancenón Galarza, F.; Villalonga, R.... (2018). Hybrid Mesoporous Nanocarriers Act by Processing Logic Tasks: Toward the Design of Nanobots Capable of Reading Information from the Environment. ACS Applied Materials & Interfaces. 10(31):26494-26500. https://doi.org/10.1021/acsami.8b05920
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/143326
Title:
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Hybrid Mesoporous Nanocarriers Act by Processing Logic Tasks: Toward the Design of Nanobots Capable of Reading Information from the Environment
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Author:
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Llopis-Lorente, Antoni
de Luis-Fernández, Beatriz
García-Fernández, Alba
Jiménez-Falcao, Sandra
Orzaez, Mar
Sancenón Galarza, Félix
Villalonga, Reynaldo
Martínez-Máñez, Ramón
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UPV Unit:
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Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia
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Issued date:
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Abstract:
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[EN] Here, we present the design of smart nano-devices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au-mesoporous ...[+]
[EN] Here, we present the design of smart nano-devices capable of reading molecular information from the environment and acting accordingly by processing Boolean logic tasks. As proof of concept, we prepared Au-mesoporous silica (MS) nanoparticles functionalized with the enzyme glucose dehydrogenase (GDH) on the Au surface and with supramolecular nanovalves as caps on the MS surface, which is loaded with a cargo (dye or drug). The nanodevice acts as an AND logic gate and reads information from the solution (presence of glucose and nicotinamide adenine dinucleotide (NADI), which results in cargo release. We show the possibility of coimmobilizing GDH and the enzyme urease on nanoparticles to mimic an INHIBIT logic gate, in which the AND gate is switched off by the presence of urea. We also show that such nanodevices can deliver cytotoxic drugs in cancer cells by recognizing intracellular NAD(+) and the presence of glucose.
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Subjects:
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Biocomputing
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Nanorobots
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Logic gates
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Mesoporous nanoparticles
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Drug delivery
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Copyrigths:
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Reserva de todos los derechos
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Source:
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ACS Applied Materials & Interfaces. (issn:
1944-8244
)
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DOI:
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10.1021/acsami.8b05920
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Publisher:
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American Chemical Society
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Publisher version:
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https://doi.org/10.1021/acsami.8b05920
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Project ID:
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info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F061/
...[+]
info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F061/
info:eu-repo/grantAgreement/CAM//S2013%2FMIT-3029/
info:eu-repo/grantAgreement/MINECO//CTQ2014-58989-P/ES/BIONANORROBOTS QUIMICAMENTE PROGRAMADOS Y CONTROLADOS POR ENZIMAS/
info:eu-repo/grantAgreement/MINECO//CTQ2015-71936-REDT/ES/MODIFICACION QUIMICA DEL GRAFENO PARA NUEVAS PROPIEDADES Y APLICACIONES/
info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/
info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/
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Thanks:
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A.L.-L. is grateful to "La Caixa" Banking Foundation for his Ph.D. grant. A.G.-F. and B.de L. thank the Spanish government for FPU fellowships. The authors are grateful to the Spanish Government (MINECO Projects ...[+]
A.L.-L. is grateful to "La Caixa" Banking Foundation for his Ph.D. grant. A.G.-F. and B.de L. thank the Spanish government for FPU fellowships. The authors are grateful to the Spanish Government (MINECO Projects MAT2015-64139-C4-1, CTQ2014-58989-P, and CTQ2015-71936-REDT) and the Generalitat Valencia (Project PROMETEOII/2014/047 and PROMETEOII/2014/061) for support. The Comunidad de Madrid (S2013/MIT-3029, Programme NANOAVANSENS) is also gratefully acknowledged.
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Type:
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Artículo
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