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Regional hippocampal vulnerability in early multiple sclerosis: a dynamic pathological spreading from dentate gyrus to CA1

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Regional hippocampal vulnerability in early multiple sclerosis: a dynamic pathological spreading from dentate gyrus to CA1

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dc.contributor.author Planche, Vicent es_ES
dc.contributor.author Koubiyr, Ismail es_ES
dc.contributor.author Romero Gómez, José Enrique es_ES
dc.contributor.author Manjón Herrera, José Vicente es_ES
dc.contributor.author Coupe, Pierrick es_ES
dc.contributor.author Deloire, Mathilde es_ES
dc.contributor.author Dousset, Vincent es_ES
dc.contributor.author Brochet, Bruno es_ES
dc.contributor.author Ruet, Aurélie es_ES
dc.contributor.author Tourdias, Thomas es_ES
dc.date.accessioned 2020-05-21T03:02:18Z
dc.date.available 2020-05-21T03:02:18Z
dc.date.issued 2018-04 es_ES
dc.identifier.issn 1065-9471 es_ES
dc.identifier.uri http://hdl.handle.net/10251/143884
dc.description "This is the peer reviewed version of the following article: Planche, V., Koubiyr, I., Romero, J. E., Manjon, J. V., Coupé, P., Deloire, M., ... & Tourdias, T. (2018). Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA 1. Human brain mapping, 39(4), 1814-1824., which has been published in final form at https://doi.org/10.1002/hbm.23970. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving." es_ES
dc.description.abstract [EN] Background: Whether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (MS) and how this impacts memory performance is a current topic of debate. Method: We prospectively included 56 persons with clinically isolated syndrome (CIS) suggestive of MS in a 1-year longitudinal study, together with 55 matched healthy controls at baseline. Participants were tested for memory performance and scanned with 3T MRI to assess the volume of 5 distinct hippocampal subfields using automatic segmentation techniques. Results: At baseline, CA4/dentate gyrus was the only hippocampal subfield with a volume significantly smaller than controls (p < .01). After one year, CA4/dentate gyrus atrophy worsened (-6.4%, p < .0001) and significant CA1 atrophy appeared (both in the stratum-pyramidale and the stratum radiatum-lacunosum-moleculare, -5.6%, p < .001 and -6.2%, p < .01, respectively). CA4/dentate gyrus volume at baseline predicted CA1 volume one year after CIS (R-2 = 0.44 to 0.47, p < .001, with age, T2 lesion-load, and global brain atrophy as covariates). The volume of CA4/dentate gyrus at baseline was associated with MS diagnosis during follow-up, independently of T2-lesion load and demographic variables (p < .05). Whereas CA4/dentate gyrus volume was not correlated with memory scores at baseline, CA1 atrophy was an independent correlate of episodic verbal memory performance one year after CIS (beta = 0.87, p < .05). Conclusion: The hippocampal degenerative process spread from dentate gyrus to CA1 at the earliest stage of MS. This dynamic vulnerability is associated with MS diagnosis after CIS and will ultimately impact hippocampal-dependent memory performance. es_ES
dc.description.sponsorship ARSEP Foundation; Bordeaux University Hospital; TEVA Laboratories; French Agence Nationale de la Recherche, Grant/Award Numbers: ANR-10-LABX-57, ANR-10-LABX-43, ANR-10-IDEX-03-02, ANR-10-COHO-002; UPV, Grant/Award Numbers: UPV2016-0099, TIN2013-43457-R; Ministerio de Economia y competitividad es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation ANR/ANR-10-LABX-57 es_ES
dc.relation ANR/ANR-10-LABX-43 es_ES
dc.relation ANR/ANR-10-IDEX-03-02 es_ES
dc.relation ANR/ANR-10-COHO-002 es_ES
dc.relation UPV/UPV2016-0099, es_ES
dc.relation MINECO/TIN2013-43457-R es_ES
dc.relation.ispartof Human Brain Mapping es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Clinically isolated syndrome es_ES
dc.subject Cognition es_ES
dc.subject Dentate gyrus es_ES
dc.subject Hippocampus es_ES
dc.subject Hippocampal subfields es_ES
dc.subject MRI es_ES
dc.subject Multiple sclerosis es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Regional hippocampal vulnerability in early multiple sclerosis: a dynamic pathological spreading from dentate gyrus to CA1 es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/hbm.23970 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Planche, V.; Koubiyr, I.; Romero Gómez, JE.; Manjón Herrera, JV.; Coupe, P.; Deloire, M.; Dousset, V.... (2018). Regional hippocampal vulnerability in early multiple sclerosis: a dynamic pathological spreading from dentate gyrus to CA1. Human Brain Mapping. 39(4):1814-1824. https://doi.org/10.1002/hbm.23970 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/hbm.23970 es_ES
dc.description.upvformatpinicio 1814 es_ES
dc.description.upvformatpfin 1824 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 39 es_ES
dc.description.issue 4 es_ES
dc.relation.pasarela S\355377 es_ES
dc.contributor.funder Teva Pharmaceutical Industries es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Agence Nationale de la Recherche, Francia es_ES
dc.contributor.funder Centre Hospitalier Universitaire de Bordeaux es_ES
dc.contributor.funder Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques es_ES
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