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dc.contributor.author | Aparici-Espert, Maria Isabel | es_ES |
dc.contributor.author | García-Laínez, G. | es_ES |
dc.contributor.author | Andreu Ros, María Inmaculada | es_ES |
dc.contributor.author | Miranda Alonso, Miguel Ángel | es_ES |
dc.contributor.author | Lhiaubet, Virginie Lyria | es_ES |
dc.date.accessioned | 2020-05-21T03:02:21Z | |
dc.date.available | 2020-05-21T03:02:21Z | |
dc.date.issued | 2018-03 | es_ES |
dc.identifier.issn | 1554-8929 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/143885 | |
dc.description.abstract | [EN] In this work, the attention is focused on UVA-photosensitized reactions triggered by a DNA chromophore-containing lesion, namely 5-formyluracil. This is a major oxidatively generated lesion that exhibits an enhanced light absorption in the UVB-UVA region. The mechanistic study combining photochemical and photobiological techniques shows that irradiation of S-formyluracil leads to a triplet excited state capable of sensitizing formation of cyclobutane pyrimidine dimers in DNA via a triplet-triplet energy transfer. This demonstrates for the first time that oxidatively generated DNA damage can behave as an intrinsic sensitizer and result in an important extension of the active fraction of the solar spectrum with photocarcinogenic potential. Overall, this raises the question of an aggravated photomutagenicity of the 5-formyluracil lesion. | es_ES |
dc.description.sponsorship | The present work was supported by Spanish Government (CTQ2015-70164-P, Severo Ochoa program/SEV-2012-0267, BES-2013-066566, CSIC 2016801007), Instituto de Salud Carlos III (RD16/0006/0030, FIS PI16/01877), Generalitat Valenciana (Prometeo/2017/075). | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | American Chemical Society | es_ES |
dc.relation.ispartof | ACS Chemical Biology | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.title | Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1021/acschembio.7b01097 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BES-2013-066566/ES/BES-2013-066566/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//201680I007/ES/Fotoquímica de la reparación de lesiones bipirimidínicas en el ADN | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//SEV-2012-0267/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CTQ2015-70164-P/ES/LESIONES DEL ADN COMO FOTOSENSIBILIZADORES INTRINSECOS - CONCEPTO DE CABALLO DE TROYA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F01877/ES/Estrategia integrada de fotodiagnóstico combinando evaluación clínica, ensayos biológicos y estudios mecanísticos/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RD16%2F0006%2F0030/ES/Asma, Reacciones Adversas y Alérgicas (ARADYAL)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2017%2F075/ES/Reacciones fotoquímicas de biomoléculas/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química | es_ES |
dc.description.bibliographicCitation | Aparici-Espert, MI.; García-Laínez, G.; Andreu Ros, MI.; Miranda Alonso, MÁ.; Lhiaubet, VL. (2018). Oxidatively Generated Lesions as Internal Photosensitizers for Pyrimidine Dimerization in DNA. ACS Chemical Biology. 13(3):542-547. https://doi.org/10.1021/acschembio.7b01097 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1021/acschembio.7b01097 | es_ES |
dc.description.upvformatpinicio | 542 | es_ES |
dc.description.upvformatpfin | 547 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 13 | es_ES |
dc.description.issue | 3 | es_ES |
dc.identifier.pmid | 29300457 | es_ES |
dc.relation.pasarela | S\355493 | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |