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Evidence of the Red-Queen hypothesis from accelerated rates of evolution of genes involved in biotic interactions in Pneumocystis

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Evidence of the Red-Queen hypothesis from accelerated rates of evolution of genes involved in biotic interactions in Pneumocystis

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dc.contributor.author Delaye, Luis es_ES
dc.contributor.author Ruiz Ruiz, Susana es_ES
dc.contributor.author Calderon, Enrique es_ES
dc.contributor.author Tarazona Campos, Sonia es_ES
dc.contributor.author Conesa, A. es_ES
dc.contributor.author Moya, Andrés es_ES
dc.date.accessioned 2020-05-22T03:02:52Z
dc.date.available 2020-05-22T03:02:52Z
dc.date.issued 2018-06 es_ES
dc.identifier.issn 1759-6653 es_ES
dc.identifier.uri http://hdl.handle.net/10251/144097
dc.description.abstract [EN] Pneumocystis species are ascomycete fungi adapted to live inside the lungs of mammals. These ascomycetes show extensive stenoxenism, meaning that each species of Pneumocystis infects a single species of host. Here, we study the effect exerted by natural selection on gene evolution in the genomes of three Pneumocystis species. We show that genes involved in host interaction evolve under positive selection. In the first place, we found strong evidence of episodic diversifying selection in Major surface glycoproteins (Msg). These proteins are located on the surface of Pneumocystis and are used for host attachment and probably for immune system evasion. Consistent with their function as antigens, most sites under diversifying selection in Msg code for residues with large relative surface accessibility areas. We also found evidence of positive selection in part of the cell machinery used to export Msg to the cell surface. Specifically, we found that genes participating in glycosylphosphatidylinositol (GPI) biosynthesis show an increased rate of nonsynonymous substitutions (dN) versus synonymous substitutions (dS). GPI is a molecule synthesized in the endoplasmic reticulum that is used to anchor proteins to membranes. We interpret the aforementioned findings as evidence of selective pressure exerted by the host immune system on Pneumocystis species, shaping the evolution of Msg and several proteins involved in GPI biosynthesis. We suggest that genome evolution in Pneumocystis is well described by the Red-Queen hypothesis whereby genes relevant for biotic interactions show accelerated rates of evolution. es_ES
dc.description.sponsorship L.D. wishes to thank Eugenia Flores and Ana Fayos for support provided. This project has received funding from the Marie Curie International Research Staff Exchange Scheme within the 7th European Community Framework Program under grant agreement No 612583-DEANN. Part of this work was done during an internship of L.D. as invited professor at the Universidad de Valencia. Support from CONACYT (grant 454938) is gratefully acknowledged. This work was supported by grants to A.M. from the Spanish Ministry of Science and Competitivity (projects SAF 2012-31187, SAF2013-49788-EXP, SAF2015-65878-R), Carlos III Institute of Health (projects PIE14/00045, AC 15/00022 and AC15/00042), Generalitat Valenciana (project PrometeoII/2014/065) and cofinanced by FEDER. es_ES
dc.language Inglés es_ES
dc.publisher Oxford University Press es_ES
dc.relation.ispartof Genome Biology and Evolution es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject Stenoxenism es_ES
dc.subject Majors surface glycoproteins es_ES
dc.subject Glycosylphosphatidylinositol es_ES
dc.subject Natural selection es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Evidence of the Red-Queen hypothesis from accelerated rates of evolution of genes involved in biotic interactions in Pneumocystis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1093/gbe/evy116 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/612583/EU/Developing an European American NGS Network/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SAF2012-31187/ES/INTERACCION DEL MICROBIOMA Y EL VIROMA DEL INTESTINO HUMANO EN CONDICIONES DE SALUD, ENFERMEDAD Y ESTRES ANTIBIOTICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONACyT//454938/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PIE14%2F00045/ES/Identification of novel modulators of chronic inflammation in prevalent diseases: unveiling divergent mechanisms of disease/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//AC 15%2F00022/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AC15%2F00042/ES/Recognition of the primary infection by Pneumocystis in infants: a silent threat to public health/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F065/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SAF2013-49788-EXP/ES/INNOVACION EN MODELOS COMPUTACIONALES PREDICTIVOS EN EPIDEMIOLOGIA EXPERIMENTAL DE LA RESISTENCIA A LOS ANTIBIOTICOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SAF2015-65878-R/ES/ESTABILIDAD, RESILIENCIA Y REDUNDANCIA FUNCIONAL DE LA MICROBIOTA INTESTINAL HUMANA DURANTE EL DESARROLLO Y EN RESPUESTA AL ESTRES ANTIBIOTICO Y A CLOSTRIDIUM DIFFICILE/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Estadística e Investigación Operativa Aplicadas y Calidad - Departament d'Estadística i Investigació Operativa Aplicades i Qualitat es_ES
dc.description.bibliographicCitation Delaye, L.; Ruiz Ruiz, S.; Calderon, E.; Tarazona Campos, S.; Conesa, A.; Moya, A. (2018). Evidence of the Red-Queen hypothesis from accelerated rates of evolution of genes involved in biotic interactions in Pneumocystis. Genome Biology and Evolution. 10(6):1596-1606. https://doi.org/10.1093/gbe/evy116 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1093/gbe/evy116 es_ES
dc.description.upvformatpinicio 1596 es_ES
dc.description.upvformatpfin 1606 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 6 es_ES
dc.identifier.pmid 29893833 es_ES
dc.identifier.pmcid PMC6012782 es_ES
dc.relation.pasarela S\366120 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Consejo Nacional de Ciencia y Tecnología, México es_ES
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