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Engineered Contrast Agents in a Single Structure for T1-T2 Dual Magnetic Resonance Imaging

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Engineered Contrast Agents in a Single Structure for T1-T2 Dual Magnetic Resonance Imaging

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dc.contributor.author Cabrera-García, Alejandro es_ES
dc.contributor.author Checa-Chavarria, Elisa es_ES
dc.contributor.author Pacheco-Torres, Jesús es_ES
dc.contributor.author Bernabeu-Sanz, Angela es_ES
dc.contributor.author Vidal Moya, José Alejandro es_ES
dc.contributor.author Rivero-Buceta, Eva María es_ES
dc.contributor.author Sastre Navarro, German Ignacio es_ES
dc.contributor.author Fernandez Jover, Eduardo es_ES
dc.contributor.author Botella Asuncion, Pablo es_ES
dc.date.accessioned 2020-05-22T03:02:56Z
dc.date.available 2020-05-22T03:02:56Z
dc.date.issued 2018-04-14 es_ES
dc.identifier.issn 2040-3364 es_ES
dc.identifier.uri http://hdl.handle.net/10251/144100
dc.description.abstract [EN] The development of contrast agents (CAs) for Magnetic Resonance Imaging (MRI) with T-1-T-2 dual-mode relaxivity requires the accurate assembly of T-1 and T-2 magnetic centers in a single structure. In this context, we have synthesized a novel hybrid material by monitoring the formation of Prussian Blue analogue Gd(H2O)(4)[Fe(CN)(6)] nanoparticles with tailored shape (from nanocrosses to nanorods) and size, and further protection with a thin and homogeneous silica coating through hydrolysis and polymerization of silicate at neutral pH. The resulting Gd(H2O)(4)[Fe(CN)(6)]@SiO2 magnetic nanoparticles are very stable in biological fluids. Interestingly, this combination of Gd and Fe magnetic centers closely packed in the crystalline network promotes a magnetic synergistic effect, which results in significant improvement of longitudinal relaxivity with regards to soluble Gd3+ chelates, whilst keeping the high transversal relaxivity inherent to the iron component. As a consequence, this material shows excellent activity as MRI CA, improving positive and negative contrasts in T-1- and T-2-weighted MR images, both in in vitro (e.g., phantom) and in vivo (e.g., Sprague-Dawley rats) models. In addition, this hybrid shows a high biosafety profile and has strong ability to incorporate organic molecules on the surface with variable functionality, displaying great potential for further clinical application. es_ES
dc.description.sponsorship Financial support of the Spanish Ministry of Economy and Competitiveness (projects TEC2016-80976-R and SEV-2016-0683) is gratefully acknowledged. Dr E. M. Rivero thanks the Cursol Foundation for a post-doctoral scholarship. A. C. G. also thanks the La Caixa Foundation for a Ph.D. scholarship. We fully appreciate the assistance of the Electron Microscopy Service of the UPV and INSCANNER S.L. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Nanoscale es_ES
dc.rights Reserva de todos los derechos es_ES
dc.title Engineered Contrast Agents in a Single Structure for T1-T2 Dual Magnetic Resonance Imaging es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c7nr07948f es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2016-80976-R/ES/CONTROL DE NANOPARTICULAS MAGNETICAS PARA TERAPIA GUIADA POR IMAGEN/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SEV-2016-0683/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Cabrera-García, A.; Checa-Chavarria, E.; Pacheco-Torres, J.; Bernabeu-Sanz, A.; Vidal Moya, JA.; Rivero-Buceta, EM.; Sastre Navarro, GI.... (2018). Engineered Contrast Agents in a Single Structure for T1-T2 Dual Magnetic Resonance Imaging. Nanoscale. 10(14):6349-6360. https://doi.org/10.1039/c7nr07948f es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c7nr07948f es_ES
dc.description.upvformatpinicio 6349 es_ES
dc.description.upvformatpfin 6360 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 10 es_ES
dc.description.issue 14 es_ES
dc.identifier.pmid 29560985 es_ES
dc.relation.pasarela S\355371 es_ES
dc.contributor.funder Fundación Cursol es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Fundació Bancària Caixa d'Estalvis i Pensions de Barcelona es_ES
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