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Combining magnetic hyperthermia and dual T1/T2 MR imaging using highly versatile iron oxide nanoparticles

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Combining magnetic hyperthermia and dual T1/T2 MR imaging using highly versatile iron oxide nanoparticles

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dc.contributor.author Sánchez-Cabezas, Santiago es_ES
dc.contributor.author Montes-Robles, Roberto es_ES
dc.contributor.author Gallo, J. es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2020-05-29T03:32:15Z
dc.date.available 2020-05-29T03:32:15Z
dc.date.issued 2019-03-28 es_ES
dc.identifier.issn 1477-9226 es_ES
dc.identifier.uri http://hdl.handle.net/10251/144556
dc.description.abstract [EN] Magnetic hyperthermia and magnetic resonance imaging (MRI) are two of the most important biomedical applications of magnetic nanoparticles (MNPs). However, the design of MNPs with good heating performance for hyperthermia and dual T1/T2 contrast for MRI remains a considerable challenge. In this work, ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) are synthesized through a simple one-step methodology. A post-synthetic purification strategy has been implemented in order to separate discrete nanoparticles from aggregates and unstable nanoparticles, leading to USPIONs that preserve chemical and colloidal stability for extended periods of time. The optimized nanoparticles exhibit high saturation magnetization and show good heating efficiency in magnetic hyperthermia experiments. Remarkably, the evaluation of the USPIONs as MRI contrast agents revealed that the nanoparticles are also able to provide significant dual T1/T2 signal enhancement. These promising results demonstrate that USPIONs are excellent candidates for the development of theranostic nanodevices with potential application in both hyperthermia and dual T1/T2 MR imaging. es_ES
dc.description.sponsorship We are grateful to the Spanish Government (projects MAT2015-64139-C4-1-R and AGL2015-70235-C2-2-R (MINECO/FEDER)) and the Generalitat Valenciana (Projects PROMETEO/2018/024 and PROMETEOII/2014/047) for financial support. S. S. C. is grateful to the Spanish MEC for his FPU grant. JG acknowledges funding from FCT and the ERDF through NORTE2020 through the project Self-reporting immunestimulating formulation for on-demand cancer therapy with real-time treatment response monitoring (028052). es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof Dalton Transactions es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Contrast agents es_ES
dc.subject Particle Hyperthermia es_ES
dc.subject Size es_ES
dc.subject Exchange es_ES
dc.subject Uniform es_ES
dc.subject Design es_ES
dc.subject Fluid es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Combining magnetic hyperthermia and dual T1/T2 MR imaging using highly versatile iron oxide nanoparticles es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c8dt04685a es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FEDER//NORTE-01-0145-FEDER-028052/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//AGL2015-70235-C2-2-R/ES/DESARROLLO DE SISTEMAS HIBRIDOS CON OPTIMIZACION DEL ANCLADO DE BIOMOLECULAS Y DISEÑADOS CON PROPIEDADES DE ENCAPSULACION Y LIBERACION CONTROLADA MEJORADAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Tecnología Eléctrica - Institut de Tecnologia Elèctrica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Sánchez-Cabezas, S.; Montes-Robles, R.; Gallo, J.; Sancenón Galarza, F.; Martínez-Máñez, R. (2019). Combining magnetic hyperthermia and dual T1/T2 MR imaging using highly versatile iron oxide nanoparticles. Dalton Transactions. 48(12):3883-3892. https://doi.org/10.1039/c8dt04685a es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c8dt04685a es_ES
dc.description.upvformatpinicio 3883 es_ES
dc.description.upvformatpfin 3892 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 48 es_ES
dc.description.issue 12 es_ES
dc.relation.pasarela S\382040 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Fundação para a Ciência e a Tecnologia, Portugal es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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