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Organocatalytic enantioselective functionalization of indoles in the carbocyclic ring with cyclic imines

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Organocatalytic enantioselective functionalization of indoles in the carbocyclic ring with cyclic imines

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dc.contributor.author Vila, C. es_ES
dc.contributor.author Tortosa, A. es_ES
dc.contributor.author Blay, G. es_ES
dc.contributor.author Muñoz Roca, María Del Carmen es_ES
dc.contributor.author Pedro, J.R. es_ES
dc.date.accessioned 2020-05-29T03:32:52Z
dc.date.available 2020-05-29T03:32:52Z
dc.date.issued 2019-01-07 es_ES
dc.identifier.issn 1144-0546 es_ES
dc.identifier.uri http://hdl.handle.net/10251/144569
dc.description.abstract [EN] An organocatalytic enantioselective functionalization in the carbocyclic ring of indoles with benzoxathiazine 2,2-dioxides is described using a quinine-derived bifunctional organocatalyst. This aza-Friedel-Crafts reaction provides 4-indolyl, 5-indolyl and 7-indolyl sulfamidate derivatives in good yields (up to 99%) and with moderate to high enantioselectivities (up to 86% ee). es_ES
dc.description.sponsorship Financial support from the Agencia Estatal de Investigación (AEI, Spanish Government) and Fondo Europeo de Desarrollo Regional (FEDER, European Union) (CTQ2017-84900-P) is acknowledged. C. V. thanks the Spanish Government for the RyC contract (RYC-2016-20187). es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof New Journal of Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Friedel-Crafts reaction es_ES
dc.subject Asymmetric-Synthesis es_ES
dc.subject Alkylation es_ES
dc.subject Ketimines es_ES
dc.subject Hydroxyindoles es_ES
dc.subject Construction es_ES
dc.subject Derivatives es_ES
dc.subject Inhibitors es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Organocatalytic enantioselective functionalization of indoles in the carbocyclic ring with cyclic imines es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c8nj05577g es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84900-P/ES/REACCIONES DE ADICION ENANTIOSELECTIVAS MEDIANTE SISTEMAS MULTICATALITICOS. HERRAMIENTAS PARA LA SINTESIS EFICIENTE DE MOLECULAS CON ACTIVIDAD FARMACOLOGICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RYC-2016-20187/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Vila, C.; Tortosa, A.; Blay, G.; Muñoz Roca, MDC.; Pedro, J. (2019). Organocatalytic enantioselective functionalization of indoles in the carbocyclic ring with cyclic imines. New Journal of Chemistry. 43(1):130-134. https://doi.org/10.1039/c8nj05577g es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c8nj05577g es_ES
dc.description.upvformatpinicio 130 es_ES
dc.description.upvformatpfin 134 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 43 es_ES
dc.description.issue 1 es_ES
dc.relation.pasarela S\392183 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Ciencia, Innovación y Universidades es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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