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Correlated response to selection for litter size environmental variability in rabbits' resilience

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Correlated response to selection for litter size environmental variability in rabbits' resilience

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dc.contributor.author ARGENTE, M.J. es_ES
dc.contributor.author GARCIA, M.L. es_ES
dc.contributor.author ZBYNOVSKA, K. es_ES
dc.contributor.author PETRUSKA, P. es_ES
dc.contributor.author CAPCAROVA, M. es_ES
dc.contributor.author Blasco Mateu, Agustín es_ES
dc.date.accessioned 2020-05-29T03:33:11Z
dc.date.available 2020-05-29T03:33:11Z
dc.date.issued 2019-10 es_ES
dc.identifier.issn 1751-7311 es_ES
dc.identifier.uri http://hdl.handle.net/10251/144577
dc.description.abstract [EN] Resilience is the ability of an animal to return soon to its initial productivity after facing diverse environmental challenges. This trait is directly related to animal welfare and it plays a key role in fluctuations of livestock productivity. A divergent selection experiment for environmental variance of litter size has been performed successfully in rabbits over ten generations. The objective of this study was to analyse resilience indicators of stress and disease in the divergent lines of this experiment. The high line showed a lower survival rate at birth than the low line (-4.1%). After correcting by litter size, the difference was -3.2%. Involuntary culling rate was higher in the high than in the low line (+12.4%). Before vaccination against viral haemorrhagic disease or myxomatosis, concentration of lymphocytes, C-reactive protein (CRP), complement C3, serum bilirubin, triglycerides and cholesterol were higher in the high line than in the low line (difference between lines +4.5%, +5.6 mu g/ml, +4.6 mg/ml, +7.9 mmol/l, +0.3 mmol/l and +0.4 mmol/l). Immunological and biochemical responses to the two vaccines were similar. After vaccination, the percentage of lymphocytes and CRP concentration were higher in the low line than in the high one (difference between lines +4.0% and +13.1 mu g/ml). The low line also showed a higher increment in bilirubin and triglycerides than the high line (+14.2 v. +8.7 mmol/l for bilirubin and +0.11 v. +0.01 mmol/l for triglycerides); these results would agree with the protective role of bilirubin and triglycerides against the larger inflammatory response found in this line. In relation to stress, the high line had higher basal concentration of cortisol than the low line (+0.2ng/ml); the difference between lines increased more than threefold after the injection of ACTH 1 to 24, the increase being greater in the high line (+0.9 ng/ml) than in the low line (+0.4 ng/ml). Selection for divergent environmental variability of litter size leads to dams with different culling rate for reproductive causes and different kits' neonatal survival. These associations suggest that the observed fitness differences are related to differences in the inflammatory response and the corticotrope response to stress, which are two important components of physiological adaptation to environmental aggressions. es_ES
dc.description.sponsorship This study is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) with the Projects AGL2014-55921, C2-1-P and C2-2-P, and AGL2017-86083, C2-1-P and C2-2-P. es_ES
dc.language Inglés es_ES
dc.publisher Cambridge University Press es_ES
dc.relation MINECO/AGL2014-55921-C2-2-P es_ES
dc.relation MINECO/AGL2017-86083-C2-2-P es_ES
dc.relation MINISTERIO DE ECONOMIA Y EMPRESA/AGL2014-55921-C2-1-P es_ES
dc.relation AEI/AGL2017-86083-C2-1-P-AR es_ES
dc.relation.ispartof Animal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cortisol es_ES
dc.subject C-reactive protein es_ES
dc.subject Inflammatory response es_ES
dc.subject Involuntary culling rate es_ES
dc.subject Vaccination es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Correlated response to selection for litter size environmental variability in rabbits' resilience es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1017/S1751731119000302 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Argente, M.; Garcia, M.; Zbynovska, K.; Petruska, P.; Capcarova, M.; Blasco Mateu, A. (2019). Correlated response to selection for litter size environmental variability in rabbits' resilience. Animal. 13(10):2348-2355. https://doi.org/10.1017/S1751731119000302 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1017/S1751731119000302 es_ES
dc.description.upvformatpinicio 2348 es_ES
dc.description.upvformatpfin 2355 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 10 es_ES
dc.relation.pasarela S\410384 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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