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A Colorimetric Probe for the Selective Detection of Norepinephrine Based on a Double Molecular Recognition with Functionalized Gold Nanoparticles

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A Colorimetric Probe for the Selective Detection of Norepinephrine Based on a Double Molecular Recognition with Functionalized Gold Nanoparticles

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dc.contributor.author Godoy-Reyes, Tania Mariel es_ES
dc.contributor.author Costero, Ana M. es_ES
dc.contributor.author Gaviña, Pablo es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.date.accessioned 2020-05-29T03:33:37Z
dc.date.available 2020-05-29T03:33:37Z
dc.date.issued 2019-03-22 es_ES
dc.identifier.uri http://hdl.handle.net/10251/144585
dc.description.abstract [EN] A simple colorimetric probe for the selective and sensitive detection of neurotransmitter norepinephrine (NE), an important biomarker in the detection of tumors such as pheochromocytoma and paraganglioma, is described. The sensing strategy is based on the use of spherical gold nanoparticles functionalized with benzaldehyde and boronic acid-terminated moieties. A double molecular recognition involving on one hand the aromatic aldehyde and the aminoalcohol group of NE, and on the other hand the boronic acid and the catechol moiety of the neurotransmitter, results in analyte triggered aggregation of the gold nanoparticles, leading to a bathochromic shift of the SPR band in the UV-vis spectrum of the probe and a clear change in the color of the solution from red to blue. Probe P1 shows a remarkable selectivity toward NE versus other catecholamine neurotransmitters (dopamine and epinephrine) and selected biomolecules (S-HIAA, L-Tyr, glucose, uric acid, Lys and glutamic acid). Moreover, a linear response to NE in the 0-1 mu M concentration range was observed and a limit of detection of 0.07 mu M in aqueous media was determined by UV-vis spectroscopy. The sensitivity of the probe toward NE in synthetic urine was also evaluated. In this medium, a limit of detection of 0.09 mu M was obtained which falls within the range of clinical interest es_ES
dc.description.sponsorship Financial support from the Spanish Government (Projects MAT2015-64139-C4-1-R and MAT2015-64139-C4-4-R) and the Generalitat Valencia (Projects PROMETEOII/2014/047 and AICO/2017/093) is gratefully acknowledged. T. Godoy-Reyes is grateful to the Generalitat Valenciana for her Santiago Grisolia fellowship. es_ES
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation MINISTERIO DE ECONOMIA Y COMPETITIVIDAD/MAT2015-64139-C4-4-R es_ES
dc.relation Generalitat Valenciana/AICO/2017/093 es_ES
dc.relation GENERALITAT VALENCIANA/PROMETEOII/2014/047 es_ES
dc.relation MINISTERIO DE ECONOMIA Y EMPRESA/MAT2015-64139-C4-1-R es_ES
dc.relation.ispartof ACS Applied Nano Materials es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Norepinephrine (NE) es_ES
dc.subject Neurotransmitters es_ES
dc.subject Gold nanoparticles es_ES
dc.subject Colorimetric detection es_ES
dc.subject Aggregation es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title A Colorimetric Probe for the Selective Detection of Norepinephrine Based on a Double Molecular Recognition with Functionalized Gold Nanoparticles es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1021/acsanm.8b02254 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Godoy-Reyes, TM.; Costero, AM.; Gaviña, P.; Martínez-Máñez, R.; Sancenón Galarza, F. (2019). A Colorimetric Probe for the Selective Detection of Norepinephrine Based on a Double Molecular Recognition with Functionalized Gold Nanoparticles. ACS Applied Nano Materials. 2(3):1367-1373. https://doi.org/10.1021/acsanm.8b02254 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1021/acsanm.8b02254 es_ES
dc.description.upvformatpinicio 1367 es_ES
dc.description.upvformatpfin 1373 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 2 es_ES
dc.description.issue 3 es_ES
dc.identifier.eissn 2574-0970 es_ES
dc.relation.pasarela S\400520 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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