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Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

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Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin

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Martínez-Martínez, M.; Rodríguez Berna, G.; Bermejo, M.; Gonzalez-Alvarez, I.; Gonzalez -Alvarez, M.; Merino, V. (2019). Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin. European Journal of Pharmaceutics and Biopharmaceutics. 136:174-183. https://doi.org/10.1016/j.ejpb.2019.01.009

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Title: Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin
Author: Martínez-Martínez, M. Rodríguez Berna, Guillermo Bermejo, Marival Gonzalez-Alvarez, Isabel Gonzalez -Alvarez, Marta Merino, Virginia
Issued date:
Abstract:
[EN] Hydrogels are widely studied as drug delivery system. In this work we propose the employment of tetrakis (hydroxymethyl)phosphonium chloride as crosslinking agent to obtain covalent hydrogels based on chitosan. These ...[+]
Subjects: Camptothecin , Hydrogel , Drug delivery , Oral administration , Chemotherapy , Mucoadhesivity
Copyrigths: Cerrado
Source:
European Journal of Pharmaceutics and Biopharmaceutics. (issn: 0939-6411 )
DOI: 10.1016/j.ejpb.2019.01.009
Publisher:
Elsevier
Publisher version: https://doi.org/10.1016/j.ejpb.2019.01.009
Project ID:
MEC/FPU13/01105
MINECO/SAF2016-78756
Thanks:
Authors acknowledge partial financial support to project SAF2016-78756 from MINECO (Spanish Ministry of economy, industry and competitivity). Mayte Martinez-Martínez received a grant from the Ministry of Education and ...[+]
Type: Artículo

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