Rostoll-Berenguer, J.; Blay, G.; Muñoz Roca, MDC.; Pedro, J.; Vila, C. (2019). A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones. Organic Letters. 21(15):6011-6015. https://doi.org/10.1021/acs.orglett.9b02157
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/144829
Title:
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A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones
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Author:
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Rostoll-Berenguer, J.
Blay, G.
Muñoz Roca, María Del Carmen
Pedro, J.R.
Vila, C.
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UPV Unit:
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Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada
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Issued date:
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Abstract:
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[EN] An enantioselective photooxidative Mannich reaction of dihydroquinoxalinones with ketones by the merger of organophotoredox and asymmetric organocatalysis is described. This protocol features very mild reaction ...[+]
[EN] An enantioselective photooxidative Mannich reaction of dihydroquinoxalinones with ketones by the merger of organophotoredox and asymmetric organocatalysis is described. This protocol features very mild reaction conditions using simple and cheap catalysts (Eosin Y and (S)-Proline) for the synthesis of chiral quinoxaline derivatives with good to high yields (up to 94%) and excellent enantioselectivities (up to 99% ee).
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Subjects:
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Photoredox catalysis
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Tertiary-Amines
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Acid
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Functionalization
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Efficient
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Hydrogenation
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Methodology
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Activation
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Alkylation
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Complexes
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Copyrigths:
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Cerrado |
Source:
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Organic Letters. (issn:
1523-7060
)
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DOI:
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10.1021/acs.orglett.9b02157
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Publisher:
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American Chemical Society
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Publisher version:
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https://doi.org/10.1021/acs.orglett.9b02157
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Project ID:
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-84900-P/ES/REACCIONES DE ADICION ENANTIOSELECTIVAS MEDIANTE SISTEMAS MULTICATALITICOS. HERRAMIENTAS PARA LA SINTESIS EFICIENTE DE MOLECULAS CON ACTIVIDAD FARMACOLOGICA/
info:eu-repo/grantAgreement/MICINN//RYC-2016-20187/
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Thanks:
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Financial support from the Agencia Estatal de Investigation (AEI, Spanish Government) and Fondo Europeo de Desarrollo Regional (FEDER, European Union) (CTQ2017-84900-P) is acknowledged. J.R.-B. thanks the Ministerio de ...[+]
Financial support from the Agencia Estatal de Investigation (AEI, Spanish Government) and Fondo Europeo de Desarrollo Regional (FEDER, European Union) (CTQ2017-84900-P) is acknowledged. J.R.-B. thanks the Ministerio de Ciencia, Innovacion y Universidades for an FPU predoctoral contract, and C.V. thanks the Agencia Estatal de Investigacion (AEI, Spanish Government) for an RyC contract (RYC-2016-20187).
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Type:
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Artículo
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