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Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression

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Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression

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dc.contributor.author Pucci, M. es_ES
dc.contributor.author Asiain, P.R. es_ES
dc.contributor.author Durendez-Saez, Elena es_ES
dc.contributor.author Jantus-Lewintre, Eloisa es_ES
dc.contributor.author Malarani, M. es_ES
dc.contributor.author Khan, S. es_ES
dc.contributor.author Fontana, S. es_ES
dc.contributor.author Naing, A. es_ES
dc.contributor.author Passiglia, F. es_ES
dc.contributor.author Raez, L.E. es_ES
dc.contributor.author Rolfo, C. es_ES
dc.contributor.author Taverna, S. es_ES
dc.date.accessioned 2020-06-03T05:53:09Z
dc.date.available 2020-06-03T05:53:09Z
dc.date.issued 2018-04 es_ES
dc.identifier.issn 1776-2596 es_ES
dc.identifier.uri http://hdl.handle.net/10251/145111
dc.description.abstract [EN] Tumor-derived extracellular vesicles (EVs) have a pleiotropic role in cancer, interacting with target cells of the tumor microenvironment, such as fibroblasts, immune and endothelial cells. EVs can modulate tumor progression, angiogenic switch, metastasis, and immune escape. These vesicles are nano-shuttles containing a wide spectrum of miRNAs that contribute to tumor progression. MiRNAs contained in extracellular vesicles (EV-miRNAs) are disseminated in the extracellular space and are able to influence the expression of target genes with either tumor suppressor or oncogenic functions, depending on both parental and target cells. Metastatic cancer cells can balance their oncogenic potential by expressing miRNAs with oncogenic function, whilst exporting miRNAs with tumor suppressor roles out of the cells. Importantly, treatment of cancer cells with specific natural and chemical compounds could induce the elimination of miRNAs with oncogenic function, thereby reducing their aggressiveness. In this review, we discuss the mechanisms by which EV-miRNAs, acting as miRNAs with oncogenic or tumor suppressor functions, could contribute to cancer progression. es_ES
dc.description.sponsorship Elena Durendez has a predoctoral fellowship by Asociacion Espanola Contra el Cancer (AECC, Valencia, Spain). es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Targeted Oncology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Myelogenous Leukemia-Cells es_ES
dc.subject Exosome-Mediated transfer es_ES
dc.subject Lung-Cancer es_ES
dc.subject Suppressor-Cells es_ES
dc.subject Liquid biopsies es_ES
dc.subject Dendritic cells es_ES
dc.subject Messenger-RNAs es_ES
dc.subject Micrornas es_ES
dc.subject Proteins es_ES
dc.subject Microvesicles es_ES
dc.subject.classification BIOLOGIA CELULAR es_ES
dc.title Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s11523-018-0551-8 es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Pucci, M.; Asiain, P.; Durendez-Saez, E.; Jantus-Lewintre, E.; Malarani, M.; Khan, S.; Fontana, S.... (2018). Extracellular Vesicles As miRNA Nano-Shuttles: Dual Role in Tumor Progression. Targeted Oncology. 13(2):175-187. https://doi.org/10.1007/s11523-018-0551-8 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s11523-018-0551-8 es_ES
dc.description.upvformatpinicio 175 es_ES
dc.description.upvformatpfin 187 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 13 es_ES
dc.description.issue 2 es_ES
dc.identifier.pmid 29374391 es_ES
dc.relation.pasarela S\380330 es_ES
dc.contributor.funder Asociación Española Contra el Cáncer es_ES
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