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Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws

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Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws

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dc.contributor.author De Battista, Hernán es_ES
dc.contributor.author Jamilis, M. es_ES
dc.contributor.author Garelli, Fabricio es_ES
dc.contributor.author Picó, Jesús es_ES
dc.date.accessioned 2020-06-09T03:32:26Z
dc.date.available 2020-06-09T03:32:26Z
dc.date.issued 2018-03 es_ES
dc.identifier.issn 0005-1098 es_ES
dc.identifier.uri http://hdl.handle.net/10251/145752
dc.description.abstract [EN] This work revisits the dynamic behaviour of stirred continuous reactors in which a single bioreaction with unknown kinetics occurs. Conditions on the feeding strategy to avoid washing out the biomass and falling in batch operation are obtained. These conditions derive in a closed positively invariant region including the desired operating point. It is stated that no closed orbits may exist in this region and, furthermore, that no fixed point exists but on one of its borders. Therefore, global stability is achieved by finding a feeding law that fulfils the aforementioned invariant conditions and gives a single equilibrium for a first-order dynamics. These results are useful to determine the stability properties of different control laws and, more importantly, to design new ones. The main advantages of the proposed approach are its simplicity and that, differing from previous results, input saturation does not affect stability results. The potentiality of the developed tools is illustrated by means of classical and novel feeding laws. (C) 2017 Elsevier Ltd. All rights reserved. es_ES
dc.description.sponsorship Financed by I216-2016 (UNLP), PICT2014-2394 (ANPCyT) and PIP112-2015-01-00837 (CONICET), Argentina; and by DPI2014-55276-C5-1-R MINECO/AEI/FEDER, UE. The material in this paper was not presented at any conference. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Automatica es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Bioprocess control es_ES
dc.subject Nonlinear control es_ES
dc.subject Invariant control es_ES
dc.subject.classification INGENIERIA DE SISTEMAS Y AUTOMATICA es_ES
dc.title Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.automatica.2017.12.041 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UNLP//I216-2016/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ANPCyT//PICT-2014-2394/AR/Conmutación e invariancia de sistemas dinámicos. Aplicación al control, optimización y monitoreo de procesos y sistemas biológicos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CONICET//PIP 11220150100837/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//DPI2014-55276-C5-1-R/ES/BIOLOGIA SINTETICA PARA LA MEJORA EN BIOPRODUCCION: DISEÑO, OPTIMIZACION, MONITORIZACION Y CONTROL/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica es_ES
dc.description.bibliographicCitation De Battista, H.; Jamilis, M.; Garelli, F.; Picó, J. (2018). Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws. Automatica. 89:340-348. https://doi.org/10.1016/j.automatica.2017.12.041 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.automatica.2017.12.041 es_ES
dc.description.upvformatpinicio 340 es_ES
dc.description.upvformatpfin 348 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 89 es_ES
dc.relation.pasarela S\348822 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Universidad Nacional de La Plata, Argentina es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES
dc.contributor.funder Agencia Nacional de Promoción Científica y Tecnológica, Argentina es_ES
dc.contributor.funder Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina es_ES


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