- -

HYALURONAN BASED BIOMATERIALS FOR CENTRAL NERVOUS TISSUE REGENERATION

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

  • Estadisticas de Uso

HYALURONAN BASED BIOMATERIALS FOR CENTRAL NERVOUS TISSUE REGENERATION

Show simple item record

Files in this item

dc.contributor.advisor Monleón Pradas, Manuel es_ES
dc.contributor.author Baiget Orts, María Amparo es_ES
dc.date.accessioned 2012-01-27T10:11:59Z
dc.date.available 2012-01-27T10:11:59Z
dc.date.created 2012-01-13T09:00:00Z es_ES
dc.date.issued 2012-01-27T10:11:53Z es_ES
dc.identifier.uri http://hdl.handle.net/10251/14576
dc.description.abstract The aim of this Thesis is to investigate the use of hyaluronic acid as a material for the design of scaffolds aimed at CNS regeneration. The motivation comes from the need of searching for new strategies that allow regeneration in the central nervous system. In degenerative diseases, such as Parkinson's disease, where the progressive loss of neuronal subpopulations occurs, a permissive environment able to support regeneration and connectivity of neurons from the host tissue may be a promising therapy to recover lost functionalities. In this Thesis we have focused on the development of structures able to integrate within the brain, supporting neural cells attachment and survival. We hypothesized that hyaluronic acid provides an enabling environment and appropriate for regeneration due to its biocompatibility and diverses physiological applications. Biocompatible hydrogels based on modified hyaluronic acid were synthesized. Covalently crosslinked hyaluronic acid hydrogels, alone or in combination with acrylic polymers, were synthesized and permitted to develop different porous structures which may serve in different applications as cell supply, cell repopulation or tissue regeneration. Highly porous with interconnected spherical pores, hollow tubes or multichanneled scaffolds were developed. The processes allow for a wide range of shapes for different applications within the scope of central nervous system regeneration. Furthermore, in vitro culture of human cell lines together with biomaterials was performed. A human microvascular endothelial cell line (hCMEC/D3) and a human glioma cell line (U373) were chosen for the studies. Experiments were focused on the interaction between hyaluronan based scaffolds and those cell lines composing the blood-brain-barrier (BBB) in the central nervous system. Biocompatibility, viability and phenotype characteristics were assessed. es_ES
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València es_ES
dc.rights Reserva de todos los derechos es_ES
dc.source Riunet es_ES
dc.subject Angiogenesis es_ES
dc.subject Biomaterials es_ES
dc.subject Hyaluronic acid es_ES
dc.subject Central nervous system es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title HYALURONAN BASED BIOMATERIALS FOR CENTRAL NERVOUS TISSUE REGENERATION
dc.type Tesis doctoral es_ES
dc.identifier.doi 10.4995/Thesis/10251/14576 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Baiget Orts, MA. (2012). HYALURONAN BASED BIOMATERIALS FOR CENTRAL NERVOUS TISSUE REGENERATION [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/14576 es_ES
dc.description.accrualMethod Palancia es_ES
dc.type.version info:eu-repo/semantics/acceptedVersion es_ES
dc.relation.tesis 3718 es_ES


This item appears in the following Collection(s)

Show simple item record