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Tailored electrospun nanofibrous polycaprolactone/gelatin scaffolds into an acid hydrolytic solvent system

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Tailored electrospun nanofibrous polycaprolactone/gelatin scaffolds into an acid hydrolytic solvent system

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dc.contributor.author Gil-Castell, O. es_ES
dc.contributor.author Badia, J.D. es_ES
dc.contributor.author Ribes-Greus, A. es_ES
dc.date.accessioned 2020-06-10T03:32:16Z
dc.date.available 2020-06-10T03:32:16Z
dc.date.issued 2018-04 es_ES
dc.identifier.issn 0014-3057 es_ES
dc.identifier.uri http://hdl.handle.net/10251/145862
dc.description.abstract [EN] Blended nanofibrous scaffolds based on polycaprolactone (PCL) and gelatin (Ge) were successfully prepared. A formic/acetic acid (1:1) mixture was used to dissolve PCL/Ge blends from 100/0 to 20/80 %wt in steps of 10 %wt. The hydrolysis of the PCL diluted in the formic/acetic acid mixture was considered as a method for tailoring the surface morphology and physicochemical features of the nanofibrous PCL/Ge scaffolds as a function of the dissolution time. The fibre diameter remained in the nanoscale range for all the studied scaffolds, which is crucial to mimic the extra-cellular matrix size. The reduction of the intrinsic viscosity, molar mass and hydrodynamic radius found for the PCL molecules as a function of the dissolution time, consequently diminished the entanglement capability of the polymeric chains. Subsequently, the fibre diameter decreased as dissolution time increased, for all the studied compositions. While the crystallinity of the scaffolds with high PCL content increased as a function of the dissolution time, the scaffolds with high percentage of Ge showed the lowest crystallinity degree, which was ascribed to the hindering effect of the Ge diffused among the PCL segments. The wettability increased as a function of the Ge content due to the high hydrophilic behaviour of these molecules. It also increased as a function of the dissolution time, due to the more hydroxyl groups available in PCL segments to interact with water molecules. As a whole, the physicochemical assessment of the electrospun scaffolds revealed an effective tailoring procedure to obtain functionalised PCL/Ge scaffolds with specific properties as a function of the dissolution time before electrospinning. es_ES
dc.description.sponsorship The Spanish Ministry of Economy and Competitiveness is acknowledged for the projects POLYCELL (ENE2014-53734-C2-1-R), POLYDECARBOCELL (ENE2017-86711-C3-1-R) and UPOV13-3E-1947. The Spanish Ministry of Education, Culture and Sports is thanked for the pre-doctoral FPU grant of O. Gil-Castell (FPU13/01916). Generalitat Valenciana is thanked for the APOSTD/2014/041 for J.D. Badia. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation MINECO/UPOV13-3E-1947 es_ES
dc.relation GENERALITAT VALENCIANA/APOSTD/2014/041 es_ES
dc.relation MINISTERIO DE EDUCACION /AP2013-01916 es_ES
dc.relation MINECO/ENE2014-53734-C2-1-R-AR es_ES
dc.relation CORPORACION DE FOMENTO DE LA PRODUCCION, CORFO/LEITAT. 13CEI2-21839 es_ES
dc.relation AEI/ENE2017-86711-C3-1-R es_ES
dc.relation.ispartof European Polymer Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Electrospinning es_ES
dc.subject Scaffold es_ES
dc.subject Polycaprolactone (PCL) es_ES
dc.subject Gelatin (Ge) es_ES
dc.subject Tailoring es_ES
dc.subject Hydrolysis es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Tailored electrospun nanofibrous polycaprolactone/gelatin scaffolds into an acid hydrolytic solvent system es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.eurpolymj.2018.02.030 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Máquinas y Motores Térmicos - Departament de Màquines i Motors Tèrmics es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Tecnología de Materiales - Institut de Tecnologia de Materials es_ES
dc.description.bibliographicCitation Gil-Castell, O.; Badia, J.; Ribes-Greus, A. (2018). Tailored electrospun nanofibrous polycaprolactone/gelatin scaffolds into an acid hydrolytic solvent system. European Polymer Journal. 101:273-281. https://doi.org/10.1016/j.eurpolymj.2018.02.030 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.eurpolymj.2018.02.030 es_ES
dc.description.upvformatpinicio 273 es_ES
dc.description.upvformatpfin 281 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 101 es_ES
dc.relation.pasarela S\355789 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Educación es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder CORPORACION DE FOMENTO DE LA PRODUCCION, CORFO es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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