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Photogeneration of Quinone Methides as Latent Electrophiles for Lysine Targeting

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Photogeneration of Quinone Methides as Latent Electrophiles for Lysine Targeting

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Pérez Ruiz, R.; Molins-Molina, O.; Lence, E.; González-Bello, C.; Miranda Alonso, MÁ.; Jiménez Molero, MC. (2018). Photogeneration of Quinone Methides as Latent Electrophiles for Lysine Targeting. The Journal of Organic Chemistry. 83(21):13019-13029. https://doi.org/10.1021/acs.joc.8b01559

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Title: Photogeneration of Quinone Methides as Latent Electrophiles for Lysine Targeting
Author: Pérez Ruiz, Raul Molins-Molina, Oscar Lence, Emilio González-Bello, Concepción Miranda Alonso, Miguel Ángel Jiménez Molero, María Consuelo
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Issued date:
Abstract:
[EN] Latent electrophiles are nowadays very attractive chemical entities for drug discovery, as they are unreactive unless activated upon binding with the specific target. In this work, the utility of 4-trifluoromethyl ...[+]
Subjects: Quinone methide , Photochemistry , Lysine targeting
Copyrigths: Reserva de todos los derechos
Source:
The Journal of Organic Chemistry. (issn: 0022-3263 )
DOI: 10.1021/acs.joc.8b01559
Publisher:
American Chemical Society
Publisher version: https://doi.org/10.1021/acs.joc.8b01559
Thanks:
Financial support from the Spanish Ministry of Economy and Competiveness [CTQ2016-78875-P, SAF2016-75638-R and BES-2014-069404 (predoctoral fellowship to O.M.-M.)], the Generalitat Valenciana (PROMETEO/2017/075), the ...[+]
Type: Artículo

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