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Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

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Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations

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Mora-Fenoll, MT.; Ferrero De Loma-Osorio, JM.; Gómez García, JF.; Sobie, EA.; Trenor Gomis, BA. (2018). Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations. Frontiers in Physiology. 9. https://doi.org/10.3389/fphys.2018.01194

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Title: Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations
Author: Mora-Fenoll, María Teresa Ferrero De Loma-Osorio, José María Gómez García, Juan Francisco Sobie, Eric A. Trenor Gomis, Beatriz Ana
UPV Unit: Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica
Issued date:
Abstract:
[EN] Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ ...[+]
Subjects: Calcium handling , Heart failure , Fibrosis , Sensitivity analysis , Electrophysiology
Copyrigths: Reconocimiento (by)
Source:
Frontiers in Physiology. (issn: 1664-042X )
DOI: 10.3389/fphys.2018.01194
Publisher:
Frontiers Media SA
Publisher version: https://doi.org/10.3389/fphys.2018.01194
Project ID:
info:eu-repo/grantAgreement/NSF//1615677/US/
info:eu-repo/grantAgreement/AHA//15GRNT25490006/
info:eu-repo/grantAgreement/UPV//PAID-01-17/
info:eu-repo/grantAgreement/MINECO//DPI2016-75799-R/ES/TECNOLOGIAS COMPUTACIONALES PARA LA OPTIMIZACION DE TERAPIAS PERSONALIZADAS DE PATOLOGIAS AURICULARES Y VENTRICULARES/
Thanks:
This work was partially supported by the National Science Foundation (MCB 1615677), the American Heart Association (15GRNT25490006), the "Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2013-2016 from ...[+]
Type: Artículo

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