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Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

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Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment

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Arroyo-Crespo, JJ.; Armiñán, A.; Charbonnier, D.; Balzano-Nogueira, L.; Huertas-López, F.; Martí, C.; Tarazona Campos, S.... (2018). Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment. Biomaterials. 186:8-21. https://doi.org/10.1016/j.biomaterials.2018.09.023

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/146174

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Title: Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment
Author: Arroyo-Crespo, Juan J. Armiñán, Ana Charbonnier, David Balzano-Nogueira, Leandro Huertas-López, Francisco Martí, Cristina Tarazona Campos, Sonia Forteza, Jerónimo Conesa, A. Vicent Docon, Maria Jesus
UPV Unit: Universitat Politècnica de València. Departamento de Estadística e Investigación Operativa Aplicadas y Calidad - Departament d'Estadística i Investigació Operativa Aplicades i Qualitat
Issued date:
Abstract:
[EN] The intrinsic characteristics of the tumor microenvironment (TME), including acidic pH and overexpression of hydrolytic enzymes, offer an exciting opportunity for the rational design of TME-drug delivery systems (DDS). ...[+]
Subjects: Polymer therapeutics , Polypeptides , Tumor microenvironment , Polymer-based combination conjugates , Metastatic triple-negative breast cancer , Transcriptomics
Copyrigths: Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
Source:
Biomaterials. (issn: 0142-9612 )
DOI: 10.1016/j.biomaterials.2018.09.023
Publisher:
Elsevier
Publisher version: https://doi.org/ 10.1016/j.biomaterials.2018.09.023
Project ID: info:eu-repo/grantAgreement/EC/H2020/648831/EU
Thanks:
The authors would like to thank Dr. Stuart P. Atkinson for his collaboration in manuscript preparation and English revision, and Irene Borreda for essential immunohistological support. This work has been supported by the ...[+]
Type: Artículo

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