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The MINDVIEW project: First results

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The MINDVIEW project: First results

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dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author Pani, R. es_ES
dc.contributor.author Preziosi, Enrico es_ES
dc.contributor.author Jackson, C. es_ES
dc.contributor.author Murphy, J. es_ES
dc.contributor.author Barbera Ballester, Julio es_ES
dc.contributor.author Correcher Salvador, Carlos es_ES
dc.contributor.author Aussenhofer, Sebastian es_ES
dc.contributor.author Gareis, D. es_ES
dc.contributor.author Visvikis, Dimitris es_ES
dc.contributor.author Bert, J. es_ES
dc.contributor.author Langstrom, B. es_ES
dc.contributor.author Farde, Lars es_ES
dc.contributor.author Toth, M. es_ES
dc.contributor.author Haggkvist, J. es_ES
dc.contributor.author Caixeta, F. es_ES
dc.contributor.author Kullander, K. es_ES
dc.contributor.author Somlai-Schweiger, I. es_ES
dc.contributor.author Schwaiger, Markus es_ES
dc.date.accessioned 2020-06-17T03:38:55Z
dc.date.available 2020-06-17T03:38:55Z
dc.date.issued 2018-04 es_ES
dc.identifier.issn 0924-9338 es_ES
dc.identifier.uri http://hdl.handle.net/10251/146494
dc.description.abstract [EN] We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from C-11-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that C-11-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naive, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia. (c) 2018 Elsevier Masson SAS. All rights reserved. es_ES
dc.description.sponsorship This project is funded by EU grant FP7-HEALTH-F2-2013-603002. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof European Psychiatry es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Schizophrenia es_ES
dc.subject Positron Emission Tomography es_ES
dc.subject Silicon photomultipliers and magnetic resonance es_ES
dc.title The MINDVIEW project: First results es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.eurpsy.2018.01.002 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603002/EU/Multimodal Imaging of Neurological Disorders/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Benlloch Baviera, JM.; González Martínez, AJ.; Pani, R.; Preziosi, E.; Jackson, C.; Murphy, J.; Barbera Ballester, J.... (2018). The MINDVIEW project: First results. European Psychiatry. 50:21-27. https://doi.org/10.1016/j.eurpsy.2018.01.002 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.eurpsy.2018.01.002 es_ES
dc.description.upvformatpinicio 21 es_ES
dc.description.upvformatpfin 27 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 50 es_ES
dc.identifier.pmid 29398564 es_ES
dc.relation.pasarela S\406057 es_ES
dc.contributor.funder European Commission es_ES
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