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Analysis of the immune microenvironment in resected non-small cell lung cancer: the prognostic value of different T lymphocyte markers

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Analysis of the immune microenvironment in resected non-small cell lung cancer: the prognostic value of different T lymphocyte markers

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dc.contributor.author Usó-Marco, Marta es_ES
dc.contributor.author Jantus-Lewintre, Eloisa es_ES
dc.contributor.author Bremnes, Roy M. es_ES
dc.contributor.author Calabuig-Fariñas, Silvia es_ES
dc.contributor.author Blasco-Cordellat, Ana es_ES
dc.contributor.author Pastor, Enrique es_ES
dc.contributor.author Borreda, Irene es_ES
dc.contributor.author Molina-Pinelo, Sonia es_ES
dc.contributor.author Paz-Ares, Luis es_ES
dc.contributor.author Guijarro, Ricardo es_ES
dc.contributor.author Martorell, Miguel es_ES
dc.contributor.author Forteza, Jerónimo es_ES
dc.contributor.author Camps-Herrero, Carlos es_ES
dc.contributor.author Sirera Pérez, Rafael es_ES
dc.date.accessioned 2020-09-18T03:34:11Z
dc.date.available 2020-09-18T03:34:11Z
dc.date.issued 2016-08-16 es_ES
dc.identifier.uri http://hdl.handle.net/10251/150295
dc.description.abstract [EN] The prognosis of non-small cell lung cancer (NSCLC) remains poor and heterogeneous and new biomarkers are needed. As the immune system plays a pivotal role in cancer, the study of immune-related markers may provide valuable prognostic information of NSCLC. In 122 formalin-fixed, paraffin-embedded tumor tissue samples from early-stage NSCLC, tumor and tumor-near stromal areas were microdissected and gene expression levels of conventional and regulatory T cell markers were assessed by quantitative polymerase chain reaction. Also, the presence of infiltrating CD4+, CD8+, and FOXP3+ cells in tumor samples was assessed by immunohistochemistry. The relative proportion of conventional and regulatory T cells present in the tumor environment was assessed and found to be key to understand the importance that the immune system analysis has in the prognostics of NSCLC patients. The presence of CD8+ cells in the tumor compartment was associated with better outcome, whereas the presence of FOXP3+ cells was associated with worse overall survival. The negative prognostic value of combined biomarkers, indicating high levels of FOXP3 in the stroma and low levels of CD4 or CD8 in tumors, was observed at mRNA level and was validated by immunohistochemistry. In conclusion, the proportion of T helper and cytotoxic cells vs. regulatory T cells in different locations of the tumor microenvironment have opposite prognostic impacts in resected NSCLC. es_ES
dc.description.sponsorship This work was supported by the Red Temática de Investigación Cooperativa en Cáncer (RD12/0036/0025) and the Fondo de Investigación Sanitaria-Fondo Europeo de Desarrollo Regional (PI09/01147, PI09/01149 and PI12/02838). es_ES
dc.language Inglés es_ES
dc.publisher Impact Journals, LLC es_ES
dc.relation.ispartof Oncotarget es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject NSCLC es_ES
dc.subject Prognostic es_ES
dc.subject Immune-biomarker es_ES
dc.subject Tumor stroma es_ES
dc.subject Tumor compartment es_ES
dc.subject.classification BIOLOGIA CELULAR es_ES
dc.title Analysis of the immune microenvironment in resected non-small cell lung cancer: the prognostic value of different T lymphocyte markers es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.18632/oncotarget.10811 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0036%2F0025/ES/Cáncer/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI09%2F01149/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//PI12%2F02838/ES/Identificación de biomarcadores moleculares asociados a células madre tumorales en cáncer de pulmón no microcítico. Implicación en el desarrollo de nuevas estrategias terapéuticas/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI09%2F01147/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Usó-Marco, M.; Jantus-Lewintre, E.; Bremnes, RM.; Calabuig-Fariñas, S.; Blasco-Cordellat, A.; Pastor, E.; Borreda, I.... (2016). Analysis of the immune microenvironment in resected non-small cell lung cancer: the prognostic value of different T lymphocyte markers. Oncotarget. 7(33):52849-52861. https://doi.org/10.18632/oncotarget.10811 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.18632/oncotarget.10811 es_ES
dc.description.upvformatpinicio 52849 es_ES
dc.description.upvformatpfin 52861 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.description.issue 33 es_ES
dc.identifier.eissn 1949-2553 es_ES
dc.identifier.pmid 27463005 es_ES
dc.identifier.pmcid PMC5288153 es_ES
dc.relation.pasarela S\328169 es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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