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Analysis of mebendazole binding to its target biomolecule by laser flash photolysis

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Analysis of mebendazole binding to its target biomolecule by laser flash photolysis

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Jornet Olivé, MD.; Bosca Mayans, F.; Andreu, JM.; Domingo, L.; Tormos Faus, RE.; Miranda Alonso, MÁ. (2016). Analysis of mebendazole binding to its target biomolecule by laser flash photolysis. Journal of Photochemistry and Photobiology B Biology. 155:1-6. https://doi.org/10.1016/j.jphotobiol.2015.12.003

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Title: Analysis of mebendazole binding to its target biomolecule by laser flash photolysis
Author: Jornet Olivé, Mª Dolors Bosca Mayans, Francisco Andreu, Jose Maria Domingo, L.R. Tormos Faus, Rosa Esperanza Miranda Alonso, Miguel Ángel
UPV Unit: Universitat Politècnica de València. Departamento de Química - Departament de Química
Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
[EN] Mebendazole (MBZ) and related anticancer benzimidazoles act binding the beta-subunit of Tubulin (TU) before dimerization with alpha-TU with subsequent blocking microtubule formation. Laser flash photolysis (LFP) is a ...[+]
Subjects: Laser flash photolysis , Binding constant , Mebendazole triplet excited state , Anticancer drugs , Phosphorescence , Tubulin
Copyrigths: Cerrado
Source:
Journal of Photochemistry and Photobiology B Biology. (issn: 1011-1344 )
DOI: 10.1016/j.jphotobiol.2015.12.003
Publisher:
Elsevier
Publisher version: https://doi.org/10.1016/j.jphotobiol.2015.12.003
Thanks:
Financial support from the Spanish Government (grants CTQ2010-19909, BFU2011-23416 and SEV 2012-0267), the Generalitat Valenciana (Prometeo II/2013/005) and Comunidad de Madrid (S2010/BMD-2353) is gratefully acknowledged.[+]
Type: Artículo

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