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dc.contributor.author | Calvo, David | es_ES |
dc.contributor.author | Atienza, Felipe | es_ES |
dc.contributor.author | Saiz Rodríguez, Francisco Javier | es_ES |
dc.contributor.author | Martinez, Laura | es_ES |
dc.contributor.author | Ávila, Pablo | es_ES |
dc.contributor.author | Rubín, José | es_ES |
dc.contributor.author | Herreros, Benito | es_ES |
dc.contributor.author | Arenal, Ángel | es_ES |
dc.contributor.author | García-Fernández,Javier | es_ES |
dc.contributor.author | Ferrer, Ana | es_ES |
dc.contributor.author | Sebastian, Rafael | es_ES |
dc.contributor.author | Martinez-Camblor, Pablo | es_ES |
dc.contributor.author | Jalife, José | es_ES |
dc.contributor.author | Berenfeld, Omer | es_ES |
dc.date.accessioned | 2020-09-19T03:33:35Z | |
dc.date.available | 2020-09-19T03:33:35Z | |
dc.date.issued | 2015-10 | es_ES |
dc.identifier.issn | 1941-3149 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/150420 | |
dc.description.abstract | [EN] Background¿ Ventricular fibrillation (VF) has been proposed to be maintained by localized high-frequency sources. We tested whether spectral-phase analysis of the precordial ECG enabled identification of periodic activation patterns generated by such sources. Methods and Results¿Precordial ECGs were recorded from 15 ischemic cardiomyopathy and 15 Brugada syndrome (type 1 ECG) patients during induced VF and analyzed in the frequency-phase domain. Despite temporal variability, induced VF episodes lasting 19.6±7.9 s displayed distinctly high power at a common frequency (shared frequency, 5.7±1.1 Hz) in all leads about half of the time. In patients with Brugada syndrome, phase analysis of shared frequency showed a V1¿V6 sequence as would be expected from patients displaying a type 1 ECG pattern (P<0.001). Hilbert-based phases confirmed that the most stable sequence over the whole VF duration was V1¿V6. Analysis of shared frequency in ischemic cardiomyopathy patients with anteroseptal (n=4), apical (n=3), and inferolateral (n=4) myocardial infarction displayed a sequence starting at V1¿V2, V3¿V4, and V5¿V6, respectively, consistent with an activation origin at the scar location (P=0.005). Sequences correlated with the Hilbert-based phase analysis (P<0.001). Posterior infarction (n=4) displayed no specific sequence. On paired comparison, phase sequences during monomorphic ventricular tachycardia correlated moderately with VF (P<0.001). Moreover, there was a dominant frequency gradient from precordial leads facing the scar region to the contralateral leads (5.8±0.8 versus 5.4±1.1 Hz; P=0.004). Conclusions¿Noninvasive analysis of ventricular tachycardia and early VF in patients with Brugada syndrome and ischemic cardiomyopathy shows a predictable sequence in the frequency-phase domain, consistent with anatomic location of the arrhythmogenic substrate. | es_ES |
dc.description.sponsorship | This study was supported by the National Heart, Lung and Blood Institute (P01-HL039707, P01-HL087226 R01-HL118304); the Spanish Society of Cardiology, Arrhythmia and Electrophysiology Section; the Leducq Foundation, Paris, France; Centro Nacional de Investigaciones Cientificas, Madrid, Spain; Generalitat Valenciana, Valencia, Spain (PROMETEO/2012/030); VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica from the Ministerio de Economia y Competitividad of Spain (TIN2012-37546-C03-01); and the European Commission (European Regional Development Funds [ERDF]-FEDER) | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Ovid Technologies Wolters Kluwer -American Heart Association | es_ES |
dc.relation.ispartof | Circulation Arrhythmia and Electrophysiology | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Brugada syndrome | es_ES |
dc.subject | Electrocardiography | es_ES |
dc.subject | Myocardial infarction | es_ES |
dc.subject | Ventricular Tachycardia | es_ES |
dc.subject | Ventricular fibrillation | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1161/CIRCEP.114.002717 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/NIH//P01HL039707/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/NIH//R01HL118304/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/NIH//P01HL087226/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2012%2F030/ES/MEJORA EN LA PREVENCION Y TRATAMIENTO DE PATOLOGIAS CARDIACAS A TRAVES DE LA MODELIZACION MULTI-ESCALA Y LA SIMULACION COMPUTACIONAL (DIGITAL HEART)/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TIN2012-37546-C03-01/ES/CORAZON HUMANO COMPLETO FISIOLOGICO VIRTUAL: MEJORAS EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS ORIENTADO A PACIENTE/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica | es_ES |
dc.description.bibliographicCitation | Calvo, D.; Atienza, F.; Saiz Rodríguez, FJ.; Martinez, L.; Ávila, P.; Rubín, J.; Herreros, B.... (2015). Ventricular Tachycardia and Early Fibrillation in Patients With Brugada Syndrome and Ischemic Cardiomyopathy Show Predictable Frequency-Phase Properties on the Precordial ECG Consistent With the Respective Arrhythmogenic Substrate. Circulation Arrhythmia and Electrophysiology. 8(5):1133-1143. https://doi.org/10.1161/CIRCEP.114.002717 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1161/CIRCEP.114.002717 | es_ES |
dc.description.upvformatpinicio | 1133 | es_ES |
dc.description.upvformatpfin | 1143 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 8 | es_ES |
dc.description.issue | 5 | es_ES |
dc.identifier.pmid | 26253505 | es_ES |
dc.identifier.pmcid | PMC4608487 | es_ES |
dc.relation.pasarela | S\297688 | es_ES |
dc.contributor.funder | Leducq Foundation | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Sociedad Española de Cardiología | es_ES |
dc.contributor.funder | National Institutes of Health, EEUU | es_ES |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad | es_ES |
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