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Synthesis of Functionalized Indoles with a Trifluoromethy-Substituted Stereogenic Tertiary Carbon Atom Through an Enantioselective Friedel-Crafts Alkylation with beta-Trifluoromethyl-alpha, beta-enones

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Synthesis of Functionalized Indoles with a Trifluoromethy-Substituted Stereogenic Tertiary Carbon Atom Through an Enantioselective Friedel-Crafts Alkylation with beta-Trifluoromethyl-alpha, beta-enones

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Blay, G.; Fernández, I.; Muñoz Roca, MDC.; Pedro, JR.; Vila, C. (2010). Synthesis of Functionalized Indoles with a Trifluoromethy-Substituted Stereogenic Tertiary Carbon Atom Through an Enantioselective Friedel-Crafts Alkylation with beta-Trifluoromethyl-alpha, beta-enones. Chemistry - A European Journal. 16(30):9117-9122. https://doi.org/10.1002/chem.201000568

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Title: Synthesis of Functionalized Indoles with a Trifluoromethy-Substituted Stereogenic Tertiary Carbon Atom Through an Enantioselective Friedel-Crafts Alkylation with beta-Trifluoromethyl-alpha, beta-enones
Author: Blay, G. Fernández, I. Muñoz Roca, María Del Carmen Pedro, J. R. Vila, C.
UPV Unit: Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada
Issued date:
Abstract:
[EN] Chiral complexes of BINOL-based ligands with zirconium tert-butoxide catalyze the Friedel-Crafts alkylation reaction of indoles with beta-trifluoromethyl-alpha,beta-unsaturated ketones to give functionalized indoles ...[+]
Subjects: Alkylation , Aromatic substitution , Asymmetric catalysis , Enones , Fluorinated compounds
Copyrigths: Cerrado
Source:
Chemistry - A European Journal. (issn: 0947-6539 )
DOI: 10.1002/chem.201000568
Publisher:
John Wiley & Sons
Publisher version: https://doi.org/10.1002/chem.201000568
Project ID:
MINECO/CTQ2009-13083
MICINN/CTQ2006-14199
GV/ACOMP/2009/338
Thanks:
Financial support from the Ministerio de Ciencia e Innovacion and FEDER (grants CTQ2006-14199 and CTQ2009-13083) and from Generalitat Valenciana (ACOMP/2009/338) is acknowledged. CV. thanks the Generalitat Valenciana for ...[+]
Type: Artículo

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