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Photolytic Degradation of Ibuprofen. Toxicity of the Isolated Photoproducts on Fibroblasts and Erythrocytes

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Photolytic Degradation of Ibuprofen. Toxicity of the Isolated Photoproducts on Fibroblasts and Erythrocytes

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dc.contributor.author Castell, J. V. es_ES
dc.contributor.author Gómez-Lechon, M. J. es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.contributor.author Morera Bertomeu, Isabel María es_ES
dc.date.accessioned 2020-09-24T12:15:47Z
dc.date.available 2020-09-24T12:15:47Z
dc.date.issued 1987-12 es_ES
dc.identifier.issn 0031-8655 es_ES
dc.identifier.uri http://hdl.handle.net/10251/150607
dc.description.abstract [EN] The photodegradation of Ibuprofen, a widely used non¿steroidal anti¿inflammatory drug (NSAID), was examined. Several photoproducts (I¿VI) were isolated and identified on the basis of their IR¿1H¿NMR¿ and 13C¿NMR¿ spectra. The chemical structures were confirmed by unambiguous alternative synthesis from available reagents. The most significant primary photochemical process was the cleavage of the C¿C bond a to the carboxy group. Subsequent secondary processes (hydrogen abstraction, dimerization, incorporation of methanol, or reaction with oxygen) might account for the formation of the different photoproducts. The cytotoxic effects were assayed using the red¿blood cell lysis test and the enzyme leakage (LDH and GOT) from cultured fibroblasts. Compound V [l¿(4 isobutylphenyl)¿ethanol] was found to be toxic for both system at concentrations greater than 1 mM while compound IV [l¿(4 isobutylphenyl acetophenone)] was toxic for fibroblasts but not for erythrocytes at the same concentration. Ibuprofen and the other photocompounds were apparently non¿toxic. The significance of these results is discussed in connection with the possible in vivo phototoxicity of Ibuprofen. es_ES
dc.language Inglés es_ES
dc.publisher Blackwell Publishing es_ES
dc.relation.ispartof Photochemistry and Photobiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Photolytic Degradation of Ibuprofen. Toxicity of the Isolated Photoproducts on Fibroblasts and Erythrocytes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/j.1751-1097.1987.tb04882.x es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Castell, JV.; Gómez-Lechon, MJ.; Miranda Alonso, MÁ.; Morera Bertomeu, IM. (1987). Photolytic Degradation of Ibuprofen. Toxicity of the Isolated Photoproducts on Fibroblasts and Erythrocytes. Photochemistry and Photobiology. 46(6):991-996. https://doi.org/10.1111/j.1751-1097.1987.tb04882.x es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1111/j.1751-1097.1987.tb04882.x es_ES
dc.description.upvformatpinicio 991 es_ES
dc.description.upvformatpfin 996 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 46 es_ES
dc.description.issue 6 es_ES
dc.relation.pasarela S\319365 es_ES
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