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PSMA-Targeted Mesoporous Silica Nanoparticles for Selective Intracellular Delivery of Docetaxel in Prostate Cancer Cells

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PSMA-Targeted Mesoporous Silica Nanoparticles for Selective Intracellular Delivery of Docetaxel in Prostate Cancer Cells

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dc.contributor.author Rivero-Buceta, Eva María es_ES
dc.contributor.author VIDAURRE AGUT, CARLA MARIA es_ES
dc.contributor.author VERA DONOSO, CESAR DAVID es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.contributor.author MORENO MANZANO, VICTORIA es_ES
dc.contributor.author BOTELLA ASUNCION, PABLO es_ES
dc.date.accessioned 2020-09-24T12:29:34Z
dc.date.available 2020-09-24T12:29:34Z
dc.date.issued 2019-01-31 es_ES
dc.identifier.uri http://hdl.handle.net/10251/150653
dc.description.abstract [EN] Although docetaxel is currently broadly used in prostate cancer treatment, poor water solubility and systemic toxicity limit the dose and duration of therapy. In this context, although different nanoplatforms have been proposed to overcome these issues, selective therapy needs developing methodologies to target malignant cells and minimizing the impact on healthy tissue. We here present a novel drug delivery system obtained by covalent conjugation of docetaxel and an anti-prostate specific membrane antigen (PSMA) molecule (anti-FOLH1 monoclonal antibody, clone C803N) over mesoporous silica nanoparticles. This conjugate remains stable in physiological medium and shows high selectivity for LNCaP, a specific cell line that overexpresses PSMA. As a consequence, cell internalization is increased by 25%. Furthermore, cytotoxic activity of the targeted system increases by 2-fold with regard to nontargeted nanoparticles and by 2 orders with regard to the naked drug. Conversely, no targeting effect is observed over PC3, a nonbearing PSMA cell line. We expect that this therapeutic system shows strong potential for treating nonmetastatic prostate cancer, mostly through intraprostatic administration. es_ES
dc.description.sponsorship Financial support from the Spanish Ministry of Economy and Competitiveness (projects MAT2015-66666-C3-2-R, TEC2016-80976-R, and SEV-2016-0683) and the Generalitat Valenciana (project PROMETEO/2017/060) is gratefully acknowledged. We appreciate the assistance of the Electron Microscopy Service of the Universitat Politecnica de Valencia. es_ES
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof ACS Omega es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject Iron-Oxide nanoparticles es_ES
dc.subject Membrane antigen PSMA es_ES
dc.subject Expression es_ES
dc.subject Cytotoxicity es_ES
dc.subject Chemotherapy es_ES
dc.subject Resistance es_ES
dc.subject Therapy es_ES
dc.subject Surface es_ES
dc.subject Lines es_ES
dc.title PSMA-Targeted Mesoporous Silica Nanoparticles for Selective Intracellular Delivery of Docetaxel in Prostate Cancer Cells es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1021/acsomega.8b02909 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2016-80976-R/ES/CONTROL DE NANOPARTICULAS MAGNETICAS PARA TERAPIA GUIADA POR IMAGEN/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-66666-C3-2-R/ES/BIOHIBRIDOS PARA LA PROMOCION DEL CRECIMIENTO AXONAL Y LA REGENERACION EN LESION MEDULAR AGUDA Y CRONICA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2017%2F060/ES/El pasado lejano: aproximación a la conducta y la ocupación del territorio en el Paleolítico valenciano/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SEV-2016-0683/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Rivero-Buceta, EM.; Vidaurre Agut, CM.; Vera Donoso, CD.; Benlloch Baviera, JM.; Moreno Manzano, V.; Botella Asuncion, P. (2019). PSMA-Targeted Mesoporous Silica Nanoparticles for Selective Intracellular Delivery of Docetaxel in Prostate Cancer Cells. ACS Omega. 4(1):1281-1291. https://doi.org/10.1021/acsomega.8b02909 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1021/acsomega.8b02909 es_ES
dc.description.upvformatpinicio 1281 es_ES
dc.description.upvformatpfin 1291 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 4 es_ES
dc.description.issue 1 es_ES
dc.identifier.eissn 2470-1343 es_ES
dc.relation.pasarela S\406983 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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