- -

Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes

RiuNet: Repositorio Institucional de la Universidad Politécnica de Valencia

Compartir/Enviar a

Citas

Estadísticas

  • Estadisticas de Uso

Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes

Mostrar el registro sencillo del ítem

Ficheros en el ítem

[Cerrado]
Nombre: Castell;Gómez-Lec ...
Tamaño: 635.5Kb
Formato: PDF
Descripción: Versión editorial
Solicitar una copia al autor
dc.contributor.author Castell, J. V. es_ES
dc.contributor.author Gómez-Lechón, M. es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.contributor.author Morera Bertomeu, Isabel María es_ES
dc.date.accessioned 2020-09-24T12:30:23Z
dc.date.available 2020-09-24T12:30:23Z
dc.date.issued 1987-03 es_ES
dc.identifier.issn 0270-9139 es_ES
dc.identifier.uri http://hdl.handle.net/10251/150678
dc.description.abstract [EN] The photodegradation of chlorpromazine, a drug frequently used in psychotherapy, was examined under different sets of experimental conditions. A primary culture of rat hepatocytes was used to evaluate the possible hepatotoxicity of the chlorpromazine photoproducts, keeping in mind the following criteria: leakage of cytosolic enzymes; attachment index to culture plates, and albumin synthesis. Cells exposed to concentrations greater than 10¿4 M of the photomixtures showed extensive leakage of GOT and GPT into the culture medium and, at the same time, the cell attachment was seriously impaired. A concentration of 10¿7 M of the photoproducts proved capable of inhibiting the synthesis of albumin (20%). Photoproducts obtained after aerobic irradiations were as toxic for hepatocytes as those found in anaerobic conditions. The implications of our results in connection with the relevance of oxygen¿dependent photoreactions of chlorpromazine to its phototoxicity, and the possible appearance of hepatic alterations in patients treated with the drug after exposure to the sunlight, are discussed. es_ES
dc.description.sponsorship Thie study was supported by the Fondo de Investigaciones Sanitarias de la Seguridad Social (Grant 83/0982) and by the Comisión Asesora de Investigación Cientiífica y Técnica (Grant 1325) es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Hepatology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/hep.1840070223 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Ministerio de Empleo y Seguridad Social//83%2F0982 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CAICYT//1325/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Castell, JV.; Gómez-Lechón, M.; Miranda Alonso, MÁ.; Morera Bertomeu, IM. (1987). Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes. Hepatology. 7(2):349-354. https://doi.org/10.1002/hep.1840070223 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/hep.1840070223 es_ES
dc.description.upvformatpinicio 349 es_ES
dc.description.upvformatpfin 354 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.description.issue 2 es_ES
dc.relation.pasarela S\319370 es_ES
dc.contributor.funder Ministerio de Empleo y Seguridad Social es_ES
dc.contributor.funder Comisión Asesora de Investigación Científica y Técnica es_ES
dc.description.references Zelickson, A. S., & Zeller, H. C. (1964). A New and Unusual Reaction to Chlorpromazine. JAMA, 188(4). doi:10.1001/jama.1964.03060300056018 es_ES
dc.description.references Kochevar, I. E. (1981). Phototoxicity Mechanisms: Chlorpromazine Photosensitized Damage to DNA and Cell Membranes. Journal of Investigative Dermatology, 77(1), 59-64. doi:10.1111/1523-1747.ep12479244 es_ES
dc.description.references Huang, C. L., & Sands, F. L. (1964). The effect of ultraviolet irradiation on chlorpromazine. Journal of Chromatography A, 13, 246-249. doi:10.1016/s0021-9673(01)95104-0 es_ES
dc.description.references Huang, C. L., & Sands, F. L. (1967). Effect of Ultraviolet Irradiation on Chlorpromazine II. Journal of Pharmaceutical Sciences, 56(2), 259-264. doi:10.1002/jps.2600560223 es_ES
dc.description.references Grant, F. W., & Greene, J. (1972). Phototoxicity and photonucleophilic aromatic substitution in chlorpromazine. Toxicology and Applied Pharmacology, 23(1), 71-74. doi:10.1016/0041-008x(72)90205-0 es_ES
dc.description.references Iwaoka, T., & Kondo, M. (1974). Mechanistic Studies on the Photooxidation of Chlorpromazine in Water and Ethanol. Bulletin of the Chemical Society of Japan, 47(4), 980-986. doi:10.1246/bcsj.47.980 es_ES
dc.description.references Epling, G. A., Black, C., & Rawal, V. (1983). Photochemistry in micelles as a model for the in vivo phototoxicity of chlorpromazine. Journal of the Chemical Society, Perkin Transactions 2, (9), 1313. doi:10.1039/p29830001313 es_ES
dc.description.references Marko, J., Vermeersch, G., Febvay-Garot, N., Caplain, S., & Lablache-Comboer, A. (1983). 1H AND13C PHOTO-CIDNP STUDY OF AQUEOUS CHLORPROMAZINE AND ANALOGS*. Photochemistry and Photobiology, 38(2), 169-175. doi:10.1111/j.1751-1097.1983.tb03858.x es_ES
dc.description.references Dung, D. V., Marien, J., De Pauw, E., & Decuyper, J. (1984). Secondary ion mass spectrometry of some promazines and photochemistry of chlorpromazine in glycerol. Organic Mass Spectrometry, 19(6), 276-279. doi:10.1002/oms.1210190603 es_ES
dc.description.references Johnson, B. E. (1974). Short Papers. Proceedings of the Royal Society of Medicine, 67(9), 871-873. doi:10.1177/003591577406700922 es_ES
dc.description.references Kochevar, I. E., & LAmola, A. A. (1979). CHLORPROMAZINE AND PROTRIPTYLINE PHOTOTOXICITY: PHOTOSENSITIZED, OXYGEN INDEPENDENT RED CELL HEMOLYSIS. Photochemistry and Photobiology, 29(4), 791-796. doi:10.1111/j.1751-1097.1979.tb07768.x es_ES
dc.description.references Kochevar, I. E., & Hom, J. (1983). PHOTOPRODUCTS OF CHLORPROMAZINE WHICH CAUSE RED BLOOD CELL LYSIS. Photochemistry and Photobiology, 37(2), 163-168. doi:10.1111/j.1751-1097.1983.tb04452.x es_ES
dc.description.references Hasei, K., Ichihashi, M., & Mojamdar, M. (1984). INVESTIGATIONS ON THE MECHANISM OF CHLORPROMAZINE PHOTOTOXICITY: EFFECTS ON LYSOSOMES OF CULTURED HUMAN FIBROBLASTS. Photochemistry and Photobiology, 40(2), 273-276. doi:10.1111/j.1751-1097.1984.tb04586.x es_ES
dc.description.references Ljunggren, B. (1977). PHENOTHIAZINE PHOTOTOXICITY: TOXIC CHLORPROMAZINE PHOTOPRODUCTS. Journal of Investigative Dermatology, 69(4), 383-386. doi:10.1111/1523-1747.ep12510313 es_ES
dc.description.references Bakri†, A., Henegouwen, G. M. J. B. van, & Chanal, J. L. (1983). PHOTOPHARMACOLOGY OF THE TRANQUILIZER CHLORDIAZEPOXIDE IN RELATION TO ITS PHOTOTOXICITY. Photochemistry and Photobiology, 38(2), 177-183. doi:10.1111/j.1751-1097.1983.tb03859.x es_ES
dc.description.references Hepatotoxicity. The adverse effects of drugs and other chemicals on the liver, Vol. 18. New York: Appleton Century Crofts, 1978: 395–404. es_ES
dc.description.references , , et al. Preservation of the adult functionality of hepatocytes in serum-free cultures. In: , eds. Hormonally defined media. A tool in cell biology. Berlin, West Germany: Springer Verlag, 1983: 333–336. es_ES
dc.description.references Inmon, J., Stead, A., Waters, M. D., & Lewtas, J. (1981). Development of a toxicity test system using primary rat liver cells. In Vitro, 17(11), 1004-1010. doi:10.1007/bf02618426 es_ES
dc.description.references Castell, J. V. M., Montoya, A., Larrauri, A., LÓPez, P., & GÓMez-L, J. (1985). Effects of benorylate and impacina on the metabolism of cultured hepatocytes. Xenobiotica, 15(8-9), 743-749. doi:10.3109/00498258509047436 es_ES
dc.description.references Berry, M. N., & Friend, D. S. (1969). HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS. Journal of Cell Biology, 43(3), 506-520. doi:10.1083/jcb.43.3.506 es_ES
dc.description.references Lopez, M. P., Gomez-Lechon, M. J., & Castell, J. V. (1984). Glycogen synthesis in serum-free cultured hepatocytes in response to insulin and dexamethasone. In Vitro, 20(12), 923-931. doi:10.1007/bf02619665 es_ES
dc.description.references . The role of fetal calf serum (FCS) during the first stages of hepatocytes cultures. In: , eds. Hormonally defined media. A tool in cell biology. Berlin, West Germany: Springer Verlag, 1983: 340–344. es_ES
dc.description.references . Aspartate aminotransferase. In: , , eds. Methods of enzymatic analysis, Vol. III. Basel, Switzerland: Verlag Chemie, 1985: 416–433. es_ES
dc.description.references . Alanine aminotransferase. In: , , eds. Methods of enzymatic analysis, Vol. III. Basel, Switzerland: Verlag Chemie, 1985: 444–455. es_ES
dc.description.references . Recent developments in the periodate method of conjugating horseradish peroxidase (HRPO) to antibodies. In: , , eds. Immunofluores-cence and related staining techniques. Amsterdam, Holland: Elsev-ier North-Holland, 1978: 215–224. es_ES
dc.description.references Abernathy, C. O., Lukacs, L., & Zimmerman, H. J. (1977). Adverse Effects of Chlorpromazine Metabolites on Isolated Hepatocytes. Experimental Biology and Medicine, 155(4), 474-478. doi:10.3181/00379727-155-39833 es_ES
dc.description.references Samuels, A. M., & Carey, M. C. (1978). Effects of chlorpromazine hydrochloride and its metabolites on Mg2+- and Na+,K+-ATPase activities of canalicular-enriched rat liver plasma membranes. Gastroenterology, 74(6), 1183-1190. doi:10.1016/0016-5085(78)90690-x es_ES
dc.description.references Davies, A. K., Navaratnam, S., & Phillips, G. O. (1976). Photochemistry of chlorpromazine [2-chloro-N-(3-dimethylaminopropyl)phenothiazine] in propan-2-ol solution. Journal of the Chemical Society, Perkin Transactions 2, (1), 25. doi:10.1039/p29760000025 es_ES
dc.description.references Saucin, M., & Van de Vorst, A. (1980). Photodynamic potentialities of some phenothiazine derivatives. Radiation and Environmental Biophysics, 17(2), 159-168. doi:10.1007/bf02027852 es_ES
dc.description.references Dujovne, C. A., & Zimmerman, H. J. (1969). Cytotoxicity of Phenothiazines on Chang Liver Cells as Measured by Enzyme Leakage. Experimental Biology and Medicine, 131(2), 583-587. doi:10.3181/00379727-131-33931 es_ES


Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem