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Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes

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Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes

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dc.contributor.author Castell, J. V. es_ES
dc.contributor.author Gómez-Lechón, M. es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.contributor.author Morera Bertomeu, Isabel María es_ES
dc.date.accessioned 2020-09-24T12:30:23Z
dc.date.available 2020-09-24T12:30:23Z
dc.date.issued 1987-03 es_ES
dc.identifier.issn 0270-9139 es_ES
dc.identifier.uri http://hdl.handle.net/10251/150678
dc.description.abstract [EN] The photodegradation of chlorpromazine, a drug frequently used in psychotherapy, was examined under different sets of experimental conditions. A primary culture of rat hepatocytes was used to evaluate the possible hepatotoxicity of the chlorpromazine photoproducts, keeping in mind the following criteria: leakage of cytosolic enzymes; attachment index to culture plates, and albumin synthesis. Cells exposed to concentrations greater than 10¿4 M of the photomixtures showed extensive leakage of GOT and GPT into the culture medium and, at the same time, the cell attachment was seriously impaired. A concentration of 10¿7 M of the photoproducts proved capable of inhibiting the synthesis of albumin (20%). Photoproducts obtained after aerobic irradiations were as toxic for hepatocytes as those found in anaerobic conditions. The implications of our results in connection with the relevance of oxygen¿dependent photoreactions of chlorpromazine to its phototoxicity, and the possible appearance of hepatic alterations in patients treated with the drug after exposure to the sunlight, are discussed. es_ES
dc.description.sponsorship Thie study was supported by the Fondo de Investigaciones Sanitarias de la Seguridad Social (Grant 83/0982) and by the Comisión Asesora de Investigación Cientiífica y Técnica (Grant 1325) es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Hepatology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/hep.1840070223 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Ministerio de Empleo y Seguridad Social//83%2F0982 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CAICYT//1325/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Castell, JV.; Gómez-Lechón, M.; Miranda Alonso, MÁ.; Morera Bertomeu, IM. (1987). Toxic Effects of the Photoproducts of Chlorpromazine on Cultured Hepatocytes. Hepatology. 7(2):349-354. https://doi.org/10.1002/hep.1840070223 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/hep.1840070223 es_ES
dc.description.upvformatpinicio 349 es_ES
dc.description.upvformatpfin 354 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 7 es_ES
dc.description.issue 2 es_ES
dc.relation.pasarela S\319370 es_ES
dc.contributor.funder Ministerio de Empleo y Seguridad Social es_ES
dc.contributor.funder Comisión Asesora de Investigación Científica y Técnica es_ES
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