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dc.contributor.author | Hernández Pérez, Manuel![]() |
es_ES |
dc.contributor.author | Fomukong, N.G.![]() |
es_ES |
dc.contributor.author | Hellyer, T.![]() |
es_ES |
dc.contributor.author | Brown, I.![]() |
es_ES |
dc.contributor.author | Dale, J.W.![]() |
es_ES |
dc.date.accessioned | 2020-09-24T12:30:33Z | |
dc.date.available | 2020-09-24T12:30:33Z | |
dc.date.issued | 1994-06 | es_ES |
dc.identifier.issn | 0950-382X | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/150680 | |
dc.description.abstract | [EN] A highly mobile insertion sequence designated IS1110 was detected in Mycobacterium avium strain LR541 following an observed increase in size of the plasmid pLR20. Genomic libraries of M. avium strains carrying either parental pLR20 or the modified plasmid (pLR20') were constructed and the sequence of the relevant clones was determined to characterize the insertion sequence and the target region. IS1110 Is a 1457bp element lacking terminal inverted repeats, and is related to IS900 (from Mycobacterium paratuberculosis), IS901 and IS902 (from M. avium) and to IS116 (from Streptomyces clavuligerus). LR541 carries several copies of IS1110. Individual colonies from the same plate show differences in Southern blot patterns when tested with an IS1110-derived probe; the ability to detect transposition events in random colonies, without any selection pressure, indicates an exceptionally high degree of mobility, which will be invaluable for transposon mutagenesis. Analyses of M. avium isolates from human, veterinary, and environmental sources showed that IS1110-hybridizing sequences are present in some M. avium isolates but they were not detected in strains of other mycobacterial species. The polymorphism exhibited in M. avium isolates suggests that this element may be useful for molecular epidemiological studies f M. avium infections. | es_ES |
dc.description.sponsorship | We are grateful for support from the Medical Research Council (Grant No. SPG 8825658), the Spanish Ministry of Education and Science (Grant No. PG90 52552468), and the Commission of the European Communities. Our thanks are due to Jack Crawford for provision of strain LR541, and to JohnJoe McFadden and Tim Doran for helpful discussions. This work benefitted from the use of the SERC SEQNET facility at Daresbury. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Blackwell Publishing | es_ES |
dc.relation.ispartof | Molecular Microbiology | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Insertion-Sequence | es_ES |
dc.subject | DNA probes | es_ES |
dc.subject | Aids patients | es_ES |
dc.subject | Pilin genes | es_ES |
dc.subject | Paratuberculosis | es_ES |
dc.subject | Intracellulare | es_ES |
dc.subject | Plasmid | es_ES |
dc.subject | Microcomputer | es_ES |
dc.subject | Tuberculosis | es_ES |
dc.subject | Epidemiology | es_ES |
dc.subject.classification | MICROBIOLOGIA | es_ES |
dc.title | Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1111/j.1365-2958.1994.tb01059.x | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MRC//SPG 8825658/GB | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//PG90-52552468/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia | es_ES |
dc.description.bibliographicCitation | Hernández Pérez, M.; Fomukong, N.; Hellyer, T.; Brown, I.; Dale, J. (1994). Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium. Molecular Microbiology. 12(5):717-724. https://doi.org/10.1111/j.1365-2958.1994.tb01059.x | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/j.1365-2958.1994.tb01059.x | es_ES |
dc.description.upvformatpinicio | 717 | es_ES |
dc.description.upvformatpfin | 724 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 12 | es_ES |
dc.description.issue | 5 | es_ES |
dc.identifier.pmid | 8052124 | es_ES |
dc.relation.pasarela | S\26603 | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | Ministerio de Educación y Ciencia | es_ES |
dc.contributor.funder | Medical Research Council, Reino Unido | es_ES |
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