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Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium

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Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium

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dc.contributor.author Hernández Pérez, Manuel es_ES
dc.contributor.author Fomukong, N.G. es_ES
dc.contributor.author Hellyer, T. es_ES
dc.contributor.author Brown, I. es_ES
dc.contributor.author Dale, J.W. es_ES
dc.date.accessioned 2020-09-24T12:30:33Z
dc.date.available 2020-09-24T12:30:33Z
dc.date.issued 1994-06 es_ES
dc.identifier.issn 0950-382X es_ES
dc.identifier.uri http://hdl.handle.net/10251/150680
dc.description.abstract [EN] A highly mobile insertion sequence designated IS1110 was detected in Mycobacterium avium strain LR541 following an observed increase in size of the plasmid pLR20. Genomic libraries of M. avium strains carrying either parental pLR20 or the modified plasmid (pLR20') were constructed and the sequence of the relevant clones was determined to characterize the insertion sequence and the target region. IS1110 Is a 1457bp element lacking terminal inverted repeats, and is related to IS900 (from Mycobacterium paratuberculosis), IS901 and IS902 (from M. avium) and to IS116 (from Streptomyces clavuligerus). LR541 carries several copies of IS1110. Individual colonies from the same plate show differences in Southern blot patterns when tested with an IS1110-derived probe; the ability to detect transposition events in random colonies, without any selection pressure, indicates an exceptionally high degree of mobility, which will be invaluable for transposon mutagenesis. Analyses of M. avium isolates from human, veterinary, and environmental sources showed that IS1110-hybridizing sequences are present in some M. avium isolates but they were not detected in strains of other mycobacterial species. The polymorphism exhibited in M. avium isolates suggests that this element may be useful for molecular epidemiological studies f M. avium infections. es_ES
dc.description.sponsorship We are grateful for support from the Medical Research Council (Grant No. SPG 8825658), the Spanish Ministry of Education and Science (Grant No. PG90 52552468), and the Commission of the European Communities. Our thanks are due to Jack Crawford for provision of strain LR541, and to JohnJoe McFadden and Tim Doran for helpful discussions. This work benefitted from the use of the SERC SEQNET facility at Daresbury. es_ES
dc.language Inglés es_ES
dc.publisher Blackwell Publishing es_ES
dc.relation.ispartof Molecular Microbiology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Insertion-Sequence es_ES
dc.subject DNA probes es_ES
dc.subject Aids patients es_ES
dc.subject Pilin genes es_ES
dc.subject Paratuberculosis es_ES
dc.subject Intracellulare es_ES
dc.subject Plasmid es_ES
dc.subject Microcomputer es_ES
dc.subject Tuberculosis es_ES
dc.subject Epidemiology es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.title Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1111/j.1365-2958.1994.tb01059.x es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MRC//SPG 8825658/GB es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MEC//PG90-52552468/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Hernández Pérez, M.; Fomukong, N.; Hellyer, T.; Brown, I.; Dale, J. (1994). Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium. Molecular Microbiology. 12(5):717-724. https://doi.org/10.1111/j.1365-2958.1994.tb01059.x es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1111/j.1365-2958.1994.tb01059.x es_ES
dc.description.upvformatpinicio 717 es_ES
dc.description.upvformatpfin 724 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 5 es_ES
dc.identifier.pmid 8052124 es_ES
dc.relation.pasarela S\26603 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Ministerio de Educación y Ciencia es_ES
dc.contributor.funder Medical Research Council, Reino Unido es_ES
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