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Calculation of the Best Basal-Bolus Combination for Postprandial Glucose Control in Insulin Pump Therapy

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Calculation of the Best Basal-Bolus Combination for Postprandial Glucose Control in Insulin Pump Therapy

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dc.contributor.author Revert, Ana es_ES
dc.contributor.author Calm, Remei es_ES
dc.contributor.author Vehí, Josep es_ES
dc.contributor.author Bondía Company, Jorge es_ES
dc.date.accessioned 2020-10-23T03:31:24Z
dc.date.available 2020-10-23T03:31:24Z
dc.date.issued 2011-02 es_ES
dc.identifier.issn 0018-9294 es_ES
dc.identifier.uri http://hdl.handle.net/10251/153040
dc.description "© 2011 IEEE. Personal use of this material is permitted. Permissíon from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertisíng or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works." es_ES
dc.description.abstract [EN] Intensive insulin therapy in type 1 diabetes is based on the well-established practice of adjusting basal and bolus insulin independently. Basal insulin delivery is designed to optimize glucose concentrations between meals and overnight, while bolus insulin delivery is designed to optimize postprandial glucose concentrations. However, this strategy shows some limitations in the postprandial glucose control, especially for meals with high carbohydrate content. Strategies based on coordinating basal and bolus insulin in the postprandial period help in overcoming these limitations. An algorithm, based on mathematically guaranteed techniques (interval analysis), is presented in this paper. It determines, given the current glycemic state of the patient and the meal to be ingested, a basal-bolus combination that will yield a tight postprandial glycemic control according to the International Diabetes Federation guidelines. For a given meal, the algorithm reveals which bolus administration mode will enable a good postprandial performance: standard, square-wave, dual-wave, or temporal basal decrement. The algorithm is validated through an in silico study using the 30 subjects in the educational version of the Food and Drug Administration accepted University of Virginia simulator. es_ES
dc.description.sponsorship This work was supported by the Spanish Government under Grants DPI-2007-66728 and DPI-2010-20764-C02, by the FEDER funds from European Union, by the Generalitat de Catalunya under Grant SGR-00296, and by the PAID-05-08 program of the Universidad Politecnica de Valencia. es_ES
dc.language Inglés es_ES
dc.publisher Institute of Electrical and Electronics Engineers es_ES
dc.relation.ispartof IEEE Transactions on Biomedical Engineering es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Insulin pump therapy es_ES
dc.subject Interval analysis es_ES
dc.subject Optimal experiment design (OED) es_ES
dc.subject Postprandial glucose control es_ES
dc.subject Set inversion es_ES
dc.subject Type 1 diabetes es_ES
dc.subject.classification INGENIERIA DE SISTEMAS Y AUTOMATICA es_ES
dc.title Calculation of the Best Basal-Bolus Combination for Postprandial Glucose Control in Insulin Pump Therapy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1109/TBME.2010.2058805 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat de Catalunya//2005SGR 00296/ES/Automation engineering and distributed systems - Ajuts per a grups de recerca consolidats (GRC)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-05-08/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MEC//DPI2007-66728-C02-01/ES/CONTROL DE GLUCEMIA EN LAZO CERRADO EN PACIENTES CON DIABETES MELLITUS 1 Y PACIENTES CRITICOS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//DPI2010-20764-C02-01/ES/NUEVAS ESTRATEGIAS DE CONTROL GLUCEMICO POSTPRANDIAL MEDIANTE TERAPIA CON BOMBA DE INSULINA EN DIABETES TIPO 1/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica es_ES
dc.description.bibliographicCitation Revert, A.; Calm, R.; Vehí, J.; Bondía Company, J. (2011). Calculation of the Best Basal-Bolus Combination for Postprandial Glucose Control in Insulin Pump Therapy. IEEE Transactions on Biomedical Engineering. 58(2):274-281. https://doi.org/10.1109/TBME.2010.2058805 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1109/TBME.2010.2058805 es_ES
dc.description.upvformatpinicio 274 es_ES
dc.description.upvformatpfin 281 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 58 es_ES
dc.description.issue 2 es_ES
dc.identifier.pmid 20639170 es_ES
dc.relation.pasarela S\41143 es_ES
dc.contributor.funder Generalitat de Catalunya es_ES
dc.contributor.funder Ministerio de Educación y Ciencia es_ES
dc.contributor.funder Ministerio de CIencia e Innovación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Universitat Politècnica de València es_ES


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