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Chitosan patterning on titanium implants

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Chitosan patterning on titanium implants

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dc.contributor.author Gilabert-Chirivella, Eduardo es_ES
dc.contributor.author Pérez-Feito, Ricardo es_ES
dc.contributor.author Ribeiro, Clarisse es_ES
dc.contributor.author Ribeiro, Sylvie es_ES
dc.contributor.author Correia, Daniela M. es_ES
dc.contributor.author González-Martín, Maria Luisa es_ES
dc.contributor.author Manero, Jose Maria es_ES
dc.contributor.author Lanceros-Mendez, S. es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2020-10-31T04:31:53Z
dc.date.available 2020-10-31T04:31:53Z
dc.date.issued 2017-10 es_ES
dc.identifier.issn 0300-9440 es_ES
dc.identifier.uri http://hdl.handle.net/10251/153776
dc.description.abstract [EN] Titanium and its alloys are widely used in medical implants because of their excellent properties. However, bacterial infection is a frequent cause of titanium-based implant failure and also compromises its osseointegration. In this study, we report a new simple method of providing titanium surfaces with antibacterial properties by alternating antibacterial chitosan domains with titanium domains in the micrometric scale. Surface micro grooves were etched on pure titanium disks at intervals of 60 pm using a modified 3D printer and were then coated with chitosan antibacterial polysaccharide. The dimensions of the patterned microgrooves made it possible to fix the chitosan domains to the titanium substrate without the need for covalent bonding. These domains were stable after 5 days of immersion in water and reduced the surface contact angle. Preliminary cell adhesion assays demonstrated that MC3T3-E1 pre-osteoblasts preferentially adhered to the titanium regions, while C2C12 myoblasts were uniformly distributed over the whole surface. es_ES
dc.description.sponsorship The authors are grateful for the financial support from the Spanish Ministry of Economy and Competitiveness through the MAT2016-76039-C4-1-R Project (including Feder funds). CIBER-BBN is an initiative funded by the VI National R & D & I Plan 2008-2011, "IniciativaIngenio 2010", Consolider Program. GIBER actions are financed by the "Institute de Salud Carlos III" with assistance from the European Regional Development Fund. CR, SR and DMC are grateful to the FCT, POPH/FSE for the SFRH/BPD/90870/2012, SFRH/BD/111478/2015 and SFRH/BD/82411/2011 grants, respectively. The authors acknowledge the assistance and advice of the Electron Microscopy Service of the UPV. We are also indebted to Dionisio Garcia Garcia and Jose Garcia Anton of the "Institute de Seguridad Industrial Radiofisica y Medio Ambiental" of the UPV for their assistance with the scanning confocal laser microscopy es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Progress in Organic Coatings es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Titanium es_ES
dc.subject Microgrooves es_ES
dc.subject Chitosan,Myoblasts es_ES
dc.subject Pre-osteoblasts es_ES
dc.subject Cell adhesion es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Chitosan patterning on titanium implants es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.porgcoat.2017.04.027 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F82411%2F2011/PT/SCAFFOLDS TRIDIMENSIONAIS BASEADOS EM NNANOFIBRAS ELECTROACTIVAS BIODEGRADÁVEIS PARA APLICAÇÃO EM ENGENHARIA DE TECIDOS/
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F111478%2F2015/PT/
dc.relation.projectID info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F90870%2F2012/PT/TAILORING ELECTRO-MECHANICALLY ACTIVE MATERIALS FOR TISSUE ENGINEERING APPLICATIONS/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Gilabert-Chirivella, E.; Pérez-Feito, R.; Ribeiro, C.; Ribeiro, S.; Correia, DM.; González-Martín, ML.; Manero, JM.... (2017). Chitosan patterning on titanium implants. Progress in Organic Coatings. 111:23-28. https://doi.org/10.1016/j.porgcoat.2017.04.027 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.porgcoat.2017.04.027 es_ES
dc.description.upvformatpinicio 23 es_ES
dc.description.upvformatpfin 28 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 111 es_ES
dc.relation.pasarela S\357252 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Fundação para a Ciência e a Tecnologia, Portugal es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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