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Cellular hydrogels based on pH-responsive chitosan-hydroxyapatite system

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Cellular hydrogels based on pH-responsive chitosan-hydroxyapatite system

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dc.contributor.author Rogina, Anamarija es_ES
dc.contributor.author Ressler, Antonia es_ES
dc.contributor.author Matie, Igor es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Marijanovic, Inga es_ES
dc.contributor.author Ivankovic, Marica es_ES
dc.contributor.author Ivankovic, Hrvoje es_ES
dc.date.accessioned 2020-10-31T04:32:33Z
dc.date.available 2020-10-31T04:32:33Z
dc.date.issued 2017-06-15 es_ES
dc.identifier.issn 0144-8617 es_ES
dc.identifier.uri http://hdl.handle.net/10251/153790
dc.description.abstract [EN] The development of bioactive injectable system as cell carrier with minimal impact on viability of encapsulated cells represents a great challenge. In the present work, we propose a new pH-responsive chitosan-hydroxyapatite-based hydrogel with sodium bicarbonate (NaHCO3) as the gelling agent. The in situ synthesis of hydroxyapatite phase has resulted in stable composite suspension and final homogeneous hydrogel. The application of sodium bicarbonate has allowed non-cytotoxic fast gelation of chitosan-hydroxyapatite within 4min, and without excess of sodium ions concentration. Rheological properties of crosslinked hydrogel have demonstrated possible behaviour as 'strong physical hydro gel'. The live dead staining has confirmed good viability and dispersion, as well as proliferation of encapsulated cells by the culture time. Presented preliminary results show good potential of chitosanhydroxyapatite/NaHCO3 as a cell carrier, whose impact on the cell differentiation need to be confirmed by encapsulation of other cell phenotypes. es_ES
dc.description.sponsorship This work has been supported in part by the Croatian Science Foundation under the project IP-2014-09-3752. The authors want to thank Carlos Garcia Fernandez from TA Instruments for helping with rheological measurements. G. Gallego Ferrer is grateful for the financial support of the Spanish Ministry of Economy and Competitiveness through the MAT2016-76039-C4-1-R project (including Feder funds) es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Carbohydrate Polymers es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Chitosan es_ES
dc.subject Hydroxyapatite es_ES
dc.subject PH-responsive hydrogel es_ES
dc.subject Rheology es_ES
dc.subject Cell encapsulation es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Cellular hydrogels based on pH-responsive chitosan-hydroxyapatite system es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.carbpol.2017.02.105 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/HRZZ//IP-2014-09-3752/HR/Development of Biocompatible Hydroxyapatite Based Materials for Bone Tissue Engineering Applications/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Rogina, A.; Ressler, A.; Matie, I.; Gallego-Ferrer, G.; Marijanovic, I.; Ivankovic, M.; Ivankovic, H. (2017). Cellular hydrogels based on pH-responsive chitosan-hydroxyapatite system. Carbohydrate Polymers. 166:173-182. https://doi.org/10.1016/j.carbpol.2017.02.105 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.carbpol.2017.02.105 es_ES
dc.description.upvformatpinicio 173 es_ES
dc.description.upvformatpfin 182 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 166 es_ES
dc.identifier.pmid 28385221 es_ES
dc.relation.pasarela S\357235 es_ES
dc.contributor.funder Croatian Science Foundation es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


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