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A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy

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A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy

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dc.contributor.author Herance, Jose Raul es_ES
dc.contributor.author García Gómez, Hermenegildo es_ES
dc.contributor.author Guitierrez Carcedo, Patricia es_ES
dc.contributor.author Navalón Oltra, Sergio es_ES
dc.contributor.author Pineda-Lucena, Antonio es_ES
dc.contributor.author Palomino-Schätzlein, M. es_ES
dc.date.accessioned 2020-11-05T04:33:59Z
dc.date.available 2020-11-05T04:33:59Z
dc.date.issued 2019-02-21 es_ES
dc.identifier.issn 0003-2654 es_ES
dc.identifier.uri http://hdl.handle.net/10251/154119
dc.description.abstract [EN] Gold nanoparticles have high potential in the biomedical area, especially in disease diagnosis and treatment. The application of these nanoparticles requires the presence of stabilizers to avoid their agglomeration. Nowadays, there is a lack of reliable methods for characterising the effect of stabilised nanoparticles on biological systems. To this end, in this study, we apply an experimental approach based on nuclear magnetic resonance spectroscopy to study the effect of gold nanoparticles, stabilised with cerium oxide or chitosan, on a human cancer cell model. The results showed that both systems have a significant effect, even at non-toxic levels, on the cellular antioxidant system. However, although particles functionalised with chitosan exerted a strong effect on the aerobic respiration, nanoparticles stabilised with cerium oxide had a higher impact on the mechanisms associated with anaerobic energy production. Therefore, even though both systems contained similar gold nanoparticles, the presence of different stabilizers strongly influenced their mode of action and potential applications in biomedicine. es_ES
dc.description.sponsorship This work was supported by the Carlos III Health Institute, the European Regional Development Fund (PI16/02064 and CP13/00252) and the Spanish Ministerio de Economia y Competitividad (SAF2014-53977-R, SAF2017-89229-R and RD12/0036/0025). In addition, JRH is a recipient of a contract from the Ministry of Health of the Carlos III Health Institute. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation nfo:eu-repo/grantAgreement/MINECO//PI16%2F02064/ES/Resistencia insulínica en miocardio como factor de riesgo cardiovascular en Diabetes Mellitus tipo 2/ es_ES
dc.relation.ispartof The Analyst es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cells es_ES
dc.subject Cytotoxicity es_ES
dc.subject Perturbations es_ES
dc.subject Proteomics es_ES
dc.subject Reveals es_ES
dc.subject Assay es_ES
dc.subject Ceria es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c8an01827h es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SAF2014-53977-R/ES/HERRAMIENTAS DE RMN PARA EL DESARROLLO DE UNA PLATAFORMA PARA LA IDENTIFIC. DE DIANAS, LA EVAL. DE FARMACOS Y LA PERSONAL. DE TRATAMIENTOS BASADA EN APROX. METABOLOMICAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CP13%2F00252/ES/CP13%2F00252/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89229-R/ES/CONTRIBUCIONES DE LA METABOLOMICA POR RMN A LA CLASIFICACION CLINICA DE PACIENTES: UN PASO ADELANTE HACIA LA MEDICINA DE PRECISION/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0036%2F0025/ES/Cáncer/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Herance, JR.; García Gómez, H.; Guitierrez Carcedo, P.; Navalón Oltra, S.; Pineda-Lucena, A.; Palomino-Schätzlein, M. (2019). A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy. The Analyst. 144(4):1265-1274. https://doi.org/10.1039/c8an01827h es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c8an01827h es_ES
dc.description.upvformatpinicio 1265 es_ES
dc.description.upvformatpfin 1274 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 144 es_ES
dc.description.issue 4 es_ES
dc.identifier.pmid 30547176 es_ES
dc.relation.pasarela S\406920 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.description.references Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2016). Cancer nanomedicine: progress, challenges and opportunities. Nature Reviews Cancer, 17(1), 20-37. doi:10.1038/nrc.2016.108 es_ES
dc.description.references Gioria, S., Lobo Vicente, J., Barboro, P., La Spina, R., Tomasi, G., Urbán, P., … Chassaigne, H. (2016). A combined proteomics and metabolomics approach to assess the effects of gold nanoparticlesin vitro. Nanotoxicology, 10(6), 736-748. doi:10.3109/17435390.2015.1121412 es_ES
dc.description.references Beik, J., Khademi, S., Attaran, N., Sarkar, S., Shakeri-Zadeh, A., Ghaznavi, H., & Ghadiri, H. (2017). A Nanotechnology-based Strategy to Increase the Efficiency of Cancer Diagnosis and Therapy: Folate-conjugated Gold Nanoparticles. Current Medicinal Chemistry, 24(39). doi:10.2174/0929867324666170810154917 es_ES
dc.description.references Nagi, N. M. S., Khair, Y. A. M., & Abdalla, A. M. E. (2017). Capacity of gold nanoparticles in cancer radiotherapy. Japanese Journal of Radiology, 35(10), 555-561. doi:10.1007/s11604-017-0671-6 es_ES
dc.description.references Gharatape, A., & Salehi, R. (2017). Recent progress in theranostic applications of hybrid gold nanoparticles. European Journal of Medicinal Chemistry, 138, 221-233. doi:10.1016/j.ejmech.2017.06.034 es_ES
dc.description.references Fang, J., Nakamura, H., & Maeda, H. (2011). The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Advanced Drug Delivery Reviews, 63(3), 136-151. doi:10.1016/j.addr.2010.04.009 es_ES
dc.description.references Haume, K., Rosa, S., Grellet, S., Śmiałek, M. A., Butterworth, K. T., Solov’yov, A. V., … Mason, N. J. (2016). Gold nanoparticles for cancer radiotherapy: a review. Cancer Nanotechnology, 7(1). doi:10.1186/s12645-016-0021-x es_ES
dc.description.references Azevedo, R. S. S., de Sousa, J. R., Araujo, M. T. F., Martins Filho, A. J., de Alcantara, B. N., Araujo, F. M. C., … Vasconcelos, P. F. C. (2018). In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus. Scientific Reports, 8(1). doi:10.1038/s41598-017-17765-5 es_ES
dc.description.references Lin, Y., Wu, Z., Wen, J., Ding, K., Yang, X., Poeppelmeier, K. R., & Marks, L. D. (2015). Adhesion and Atomic Structures of Gold on Ceria Nanostructures: The Role of Surface Structure and Oxidation State of Ceria Supports. Nano Letters, 15(8), 5375-5381. doi:10.1021/acs.nanolett.5b02694 es_ES
dc.description.references Menchón, C., Martín, R., Apostolova, N., Victor, V. M., Álvaro, M., Herance, J. R., & García, H. (2012). Gold Nanoparticles Supported on Nanoparticulate Ceria as a Powerful Agent against Intracellular Oxidative Stress. Small, 8(12), 1895-1903. doi:10.1002/smll.201102255 es_ES
dc.description.references Tiwari, P., Vig, K., Dennis, V., & Singh, S. (2011). Functionalized Gold Nanoparticles and Their Biomedical Applications. Nanomaterials, 1(1), 31-63. doi:10.3390/nano1010031 es_ES
dc.description.references Fathy, M. M., Mohamed, F. S., Elbialy, N., & Elshemey, W. M. (2018). Multifunctional Chitosan-Capped Gold Nanoparticles for enhanced cancer chemo-radiotherapy: An invitro study. Physica Medica, 48, 76-83. doi:10.1016/j.ejmp.2018.04.002 es_ES
dc.description.references Guo, X., Zhuang, Q., Ji, T., Zhang, Y., Li, C., Wang, Y., … Du, L. (2018). Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer. Carbohydrate Polymers, 195, 311-320. doi:10.1016/j.carbpol.2018.04.087 es_ES
dc.description.references Lee, Y.-H., Kim, J.-S., Kim, J.-E., Lee, M.-H., Jeon, J.-G., Park, I.-S., & Yi, H.-K. (2017). Nanoparticle mediated PPARγ gene delivery on dental implants improves osseointegration via mitochondrial biogenesis in diabetes mellitus rat model. Nanomedicine: Nanotechnology, Biology and Medicine, 13(5), 1821-1832. doi:10.1016/j.nano.2017.02.020 es_ES
dc.description.references Sun, I.-C., Na, J. H., Jeong, S. Y., Kim, D.-E., Kwon, I. C., Choi, K., … Kim, K. (2013). Biocompatible Glycol Chitosan-Coated Gold Nanoparticles for Tumor-Targeting CT Imaging. Pharmaceutical Research, 31(6), 1418-1425. doi:10.1007/s11095-013-1142-0 es_ES
dc.description.references Costa, P. M., & Fadeel, B. (2016). Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk. Toxicology and Applied Pharmacology, 299, 101-111. doi:10.1016/j.taap.2015.12.014 es_ES
dc.description.references Lv, M., Huang, W., Chen, Z., Jiang, H., Chen, J., Tian, Y., … Xu, F. (2015). Metabolomics techniques for nanotoxicity investigations. Bioanalysis, 7(12), 1527-1544. doi:10.4155/bio.15.83 es_ES
dc.description.references Nagana Gowda, G. A., Barding, G. A., Dai, J., Gu, H., Margineantu, D. H., Hockenbery, D. M., & Raftery, D. (2018). A Metabolomics Study of BPTES Altered Metabolism in Human Breast Cancer Cell Lines. Frontiers in Molecular Biosciences, 5. doi:10.3389/fmolb.2018.00049 es_ES
dc.description.references Ali, M. R. K., Wu, Y., Han, T., Zang, X., Xiao, H., Tang, Y., … El-Sayed, M. A. (2016). Simultaneous Time-Dependent Surface-Enhanced Raman Spectroscopy, Metabolomics, and Proteomics Reveal Cancer Cell Death Mechanisms Associated with Gold Nanorod Photothermal Therapy. Journal of the American Chemical Society, 138(47), 15434-15442. doi:10.1021/jacs.6b08787 es_ES
dc.description.references Esumi, K., Takei, N., & Yoshimura, T. (2003). Antioxidant-potentiality of gold–chitosan nanocomposites. Colloids and Surfaces B: Biointerfaces, 32(2), 117-123. doi:10.1016/s0927-7765(03)00151-6 es_ES
dc.description.references Du, S., Kendall, K., Toloueinia, P., Mehrabadi, Y., Gupta, G., & Newton, J. (2012). Aggregation and adhesion of gold nanoparticles in phosphate buffered saline. Journal of Nanoparticle Research, 14(3). doi:10.1007/s11051-012-0758-z es_ES
dc.description.references Ulrich, E. L., Akutsu, H., Doreleijers, J. F., Harano, Y., Ioannidis, Y. E., Lin, J., … Markley, J. L. (2007). BioMagResBank. Nucleic Acids Research, 36(Database), D402-D408. doi:10.1093/nar/gkm957 es_ES
dc.description.references Wishart, D. S., Feunang, Y. D., Marcu, A., Guo, A. C., Liang, K., Vázquez-Fresno, R., … Scalbert, A. (2017). HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Research, 46(D1), D608-D617. doi:10.1093/nar/gkx1089 es_ES
dc.description.references Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65(1-2), 55-63. doi:10.1016/0022-1759(83)90303-4 es_ES
dc.description.references Yang, L., Shang, L., & Nienhaus, G. U. (2013). Mechanistic aspects of fluorescent gold nanocluster internalization by live HeLa cells. Nanoscale, 5(4), 1537. doi:10.1039/c2nr33147k es_ES
dc.description.references Zhitomirsky, B., Farber, H., & Assaraf, Y. G. (2018). LysoTracker and MitoTracker Red are transport substrates of P‐glycoprotein: implications for anticancer drug design evading multidrug resistance. Journal of Cellular and Molecular Medicine, 22(4), 2131-2141. doi:10.1111/jcmm.13485 es_ES
dc.description.references Chong, J., Soufan, O., Li, C., Caraus, I., Li, S., Bourque, G., … Xia, J. (2018). MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis. Nucleic Acids Research, 46(W1), W486-W494. doi:10.1093/nar/gky310 es_ES
dc.description.references Stepanenko, A. A., & Dmitrenko, V. V. (2015). Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability. Gene, 574(2), 193-203. doi:10.1016/j.gene.2015.08.009 es_ES
dc.description.references Choi, S. Y., Jang, S. H., Park, J., Jeong, S., Park, J. H., Ock, K. S., … Lee, S. Y. (2012). Cellular uptake and cytotoxicity of positively charged chitosan gold nanoparticles in human lung adenocarcinoma cells. Journal of Nanoparticle Research, 14(12). doi:10.1007/s11051-012-1234-5 es_ES
dc.description.references De Carvalho, T. G., Garcia, V. B., de Araújo, A. A., da Silva Gasparotto, L. H., Silva, H., Guerra, G. C. B., … de Araújo Júnior, R. F. (2018). Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats. International Journal of Pharmaceutics, 548(1), 1-14. doi:10.1016/j.ijpharm.2018.06.008 es_ES
dc.description.references Carrola, J., Bastos, V., Ferreira de Oliveira, J. M. P., Oliveira, H., Santos, C., Gil, A. M., & Duarte, I. F. (2016). Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics. Archives of Biochemistry and Biophysics, 589, 53-61. doi:10.1016/j.abb.2015.08.022 es_ES
dc.description.references Fröhlich, E. (2012). The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. International Journal of Nanomedicine, 5577. doi:10.2147/ijn.s36111 es_ES
dc.description.references Gürer, H., Özgünes, H., Saygin, E., & Ercal, N. (2001). Antioxidant Effect of Taurine Against Lead-Induced Oxidative Stress. Archives of Environmental Contamination and Toxicology, 41(4), 397-402. doi:10.1007/s002440010265 es_ES
dc.description.references Lee, S.-H., Wang, T.-Y., Hong, J.-H., Cheng, T.-J., & Lin, C.-Y. (2016). NMR-based metabolomics to determine acute inhalation effects of nano- and fine-sized ZnO particles in the rat lung. Nanotoxicology, 10(7), 924-934. doi:10.3109/17435390.2016.1144825 es_ES
dc.description.references Saborano, R., Wongpinyochit, T., Totten, J. D., Johnston, B. F., Seib, F. P., & Duarte, I. F. (2017). Metabolic Reprogramming of Macrophages Exposed to Silk, Poly(lactic-co-glycolic acid), and Silica Nanoparticles. Advanced Healthcare Materials, 6(14), 1601240. doi:10.1002/adhm.201601240 es_ES
dc.description.references Bo, Y., Jin, C., Liu, Y., Yu, W., & Kang, H. (2014). Metabolomic analysis on the toxicological effects of TiO2nanoparticles in mouse fibroblast cells: from the perspective of perturbations in amino acid metabolism. Toxicology Mechanisms and Methods, 24(7), 461-469. doi:10.3109/15376516.2014.939321 es_ES
dc.description.references Shea, T. B., Ekinci, F. J., Ortiz, D., Dawn-Linsley, M., Wilson, T. O., & Nicolosi, R. J. (2002). Efficacy of vitamin E, phosphatidyl choline, and pyruvate on buffering neuronal degeneration and oxidative stress in cultured cortical neurons and in central nervous tissue of apolipoprotein E-deficient mice. Free Radical Biology and Medicine, 33(2), 276-282. doi:10.1016/s0891-5849(02)00872-9 es_ES
dc.description.references Schätzlein, M. P., Becker, J., Schulze-Sünninghausen, D., Pineda-Lucena, A., Herance, J. R., & Luy, B. (2018). Rapid two-dimensional ALSOFAST-HSQC experiment for metabolomics and fluxomics studies: application to a 13C-enriched cancer cell model treated with gold nanoparticles. Analytical and Bioanalytical Chemistry, 410(11), 2793-2804. doi:10.1007/s00216-018-0961-6 es_ES
dc.description.references HUNTER, A. (2006). Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity☆. Advanced Drug Delivery Reviews, 58(14), 1523-1531. doi:10.1016/j.addr.2006.09.008 es_ES
dc.description.references Ratnasekhar, C., Sonane, M., Satish, A., & Mudiam, M. K. R. (2015). Metabolomics reveals the perturbations in the metabolome ofCaenorhabditis elegansexposed to titanium dioxide nanoparticles. Nanotoxicology, 9(8), 994-1004. doi:10.3109/17435390.2014.993345 es_ES


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