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A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy

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A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy

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dc.contributor.author Herance, Jose Raul es_ES
dc.contributor.author García Gómez, Hermenegildo es_ES
dc.contributor.author Guitierrez Carcedo, Patricia es_ES
dc.contributor.author Navalón Oltra, Sergio es_ES
dc.contributor.author Pineda-Lucena, Antonio es_ES
dc.contributor.author Palomino-Schätzlein, M. es_ES
dc.date.accessioned 2020-11-05T04:33:59Z
dc.date.available 2020-11-05T04:33:59Z
dc.date.issued 2019-02-21 es_ES
dc.identifier.issn 0003-2654 es_ES
dc.identifier.uri http://hdl.handle.net/10251/154119
dc.description.abstract [EN] Gold nanoparticles have high potential in the biomedical area, especially in disease diagnosis and treatment. The application of these nanoparticles requires the presence of stabilizers to avoid their agglomeration. Nowadays, there is a lack of reliable methods for characterising the effect of stabilised nanoparticles on biological systems. To this end, in this study, we apply an experimental approach based on nuclear magnetic resonance spectroscopy to study the effect of gold nanoparticles, stabilised with cerium oxide or chitosan, on a human cancer cell model. The results showed that both systems have a significant effect, even at non-toxic levels, on the cellular antioxidant system. However, although particles functionalised with chitosan exerted a strong effect on the aerobic respiration, nanoparticles stabilised with cerium oxide had a higher impact on the mechanisms associated with anaerobic energy production. Therefore, even though both systems contained similar gold nanoparticles, the presence of different stabilizers strongly influenced their mode of action and potential applications in biomedicine. es_ES
dc.description.sponsorship This work was supported by the Carlos III Health Institute, the European Regional Development Fund (PI16/02064 and CP13/00252) and the Spanish Ministerio de Economia y Competitividad (SAF2014-53977-R, SAF2017-89229-R and RD12/0036/0025). In addition, JRH is a recipient of a contract from the Ministry of Health of the Carlos III Health Institute. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//PI16%2F02064/ES/Resistencia insulínica en miocardio como factor de riesgo cardiovascular en Diabetes Mellitus tipo 2/ es_ES
dc.relation.ispartof The Analyst es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Cells es_ES
dc.subject Cytotoxicity es_ES
dc.subject Perturbations es_ES
dc.subject Proteomics es_ES
dc.subject Reveals es_ES
dc.subject Assay es_ES
dc.subject Ceria es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c8an01827h es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//SAF2014-53977-R/ES/HERRAMIENTAS DE RMN PARA EL DESARROLLO DE UNA PLATAFORMA PARA LA IDENTIFIC. DE DIANAS, LA EVAL. DE FARMACOS Y LA PERSONAL. DE TRATAMIENTOS BASADA EN APROX. METABOLOMICAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CP13%2F00252/ES/CP13%2F00252/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-89229-R/ES/CONTRIBUCIONES DE LA METABOLOMICA POR RMN A LA CLASIFICACION CLINICA DE PACIENTES: UN PASO ADELANTE HACIA LA MEDICINA DE PRECISION/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RD12%2F0036%2F0025/ES/Cáncer/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Herance, JR.; García Gómez, H.; Guitierrez Carcedo, P.; Navalón Oltra, S.; Pineda-Lucena, A.; Palomino-Schätzlein, M. (2019). A translational approach to assess the metabolomic impact of stabilized gold nanoparticles by NMR spectroscopy. The Analyst. 144(4):1265-1274. https://doi.org/10.1039/c8an01827h es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1039/c8an01827h es_ES
dc.description.upvformatpinicio 1265 es_ES
dc.description.upvformatpfin 1274 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 144 es_ES
dc.description.issue 4 es_ES
dc.identifier.pmid 30547176 es_ES
dc.relation.pasarela S\406920 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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