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Occupation and mammographic density: A population-based study (DDM-Occup)

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Occupation and mammographic density: A population-based study (DDM-Occup)

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dc.contributor.author García-Pérez, Javier es_ES
dc.contributor.author Pollán, Marina es_ES
dc.contributor.author Pérez-Gómez, Beatriz es_ES
dc.contributor.author González-Sánchez, Mario es_ES
dc.contributor.author Cortés Barragán, Rosa Ana es_ES
dc.contributor.author Maqueda Blasco, Jerónimo es_ES
dc.contributor.author González-Galarzo, María Carmen es_ES
dc.contributor.author Alba, Miguel Ángel es_ES
dc.contributor.author van der Haar, Rudolf es_ES
dc.contributor.author Casas, Silvia es_ES
dc.contributor.author Vicente, Cándida es_ES
dc.contributor.author Medina, Pilar es_ES
dc.contributor.author Ederra, María es_ES
dc.contributor.author Santamariña, Carmen es_ES
dc.contributor.author Moreno, María Pilar es_ES
dc.contributor.author Llobet Azpitarte, Rafael es_ES
dc.date.accessioned 2020-11-17T04:32:51Z
dc.date.available 2020-11-17T04:32:51Z
dc.date.issued 2017-11 es_ES
dc.identifier.issn 0013-9351 es_ES
dc.identifier.uri http://hdl.handle.net/10251/155131
dc.description.abstract [EN] Introduction: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers. Methods: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network. Reproductive, family, personal, and occupational history data were collected. The latest occupation of each woman was collected and coded according to the 1994 National Classification of Occupations. Mammographic density was assessed from the cranio-caudal mammogram of the left breast using a semi-automated computer-assisted tool. Association between mammographic density and occupation was evaluated by using mixed linear regression models, using log-transformed percentage of mammographic density as dependent variable. Models were adjusted for age, body mass index,menopausal status, parity, smoking, alcohol intake, educational level, type of mammography, first-degree relative with breast cancer, and hormonal replacement therapy use. Screening center and professional reader were included as random effects terms. Results: Mammographic density was higher, although non-statistically significant, among secondary school teachers (e(beta) = 1.41; 95%CI = 0.98-2.03) and nurses (e(beta) = 1.23; 95%CI = 0.96-1.59), whereas workers engaged in the care of people (e(beta) = 0.81; 95%CI = 0.66-1.00) and housewives (e(beta) = 0.87; 95%CI = 0.79-0.95) showed an inverse association with mammographic density. A positive trend for every 5 years working as secondary school teachers was also detected (p-value = 0.035). Conclusions: Nurses and secondary school teachers were the occupations with the highest mammographic density in our study, showing the latter a positive trend with duration of employment. Future studies are necessary to confirm if these results are due to chance or are the result of a true association whose causal hypothesis is, for the moment, unknown. es_ES
dc.description.sponsorship This study was funded by Strategic Action of Intramural Health (Accion Estrategica de Salud Intramural - AESI PI15CIII/00013); the Scientific Foundation of the Spanish Association Against Cancer (Fundacion Cientifica de la Asociacion Espanola Contra el Cancer (AECC) EVP-1178/14); the Research Grant FIS PI060386 & PS09/790 from Spain's Health Research Fund (Fondo de Invesdgacion Sanitaria); the EPY 1306/06 Collaboration Agreement between Astra-Zeneca and the Carlos III Institute of Health; and a grant from the Spanish Federation of Breast Cancer patients (FECMA 485 EPY 1170-10). es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Environmental Research es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Mammographic density es_ES
dc.subject Occupation es_ES
dc.subject Breast cancer es_ES
dc.subject School teachers es_ES
dc.subject Nurses es_ES
dc.subject DDM-Occup es_ES
dc.subject.classification LENGUAJES Y SISTEMAS INFORMATICOS es_ES
dc.title Occupation and mammographic density: A population-based study (DDM-Occup) es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.envres.2017.08.028 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PS09%2F0790/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI060386/ES/Determinantes de la densidad mamográfica en las mujeres participantes de los programas de detección precoz del cáncer de mama en España (DDM-Spain)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//EPY1306%2F06/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FECMA//485 EPY 1170-10/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI15CIII%2F0013/ES/Ocupación, exposición laboral a agentes de riesgo, condiciones de trabajo y densidad mamográfica en mujeres españolas/DDM-Ocup/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AECC//AECC%2FEVP-1178%2F14/ES/ / es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació es_ES
dc.description.bibliographicCitation García-Pérez, J.; Pollán, M.; Pérez-Gómez, B.; González-Sánchez, M.; Cortés Barragán, RA.; Maqueda Blasco, J.; González-Galarzo, MC.... (2017). Occupation and mammographic density: A population-based study (DDM-Occup). Environmental Research. 159:355-361. https://doi.org/10.1016/j.envres.2017.08.028 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.envres.2017.08.028 es_ES
dc.description.upvformatpinicio 355 es_ES
dc.description.upvformatpfin 361 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 159 es_ES
dc.identifier.pmid 28843166 es_ES
dc.relation.pasarela S\342776 es_ES
dc.contributor.funder AstraZeneca es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Asociación Española Contra el Cáncer es_ES
dc.contributor.funder Federación Española de Cáncer de Mama es_ES


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