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Occupational exposures and mammographic density in Spanish women

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Occupational exposures and mammographic density in Spanish women

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dc.contributor.author Lope, Virginia es_ES
dc.contributor.author García-Pérez, Javier es_ES
dc.contributor.author Pérez-Gómez, Beatriz es_ES
dc.contributor.author Pedraza-Flechas, Ana María es_ES
dc.contributor.author Alguacil, Juan es_ES
dc.contributor.author González-Galarzo, María Carmen es_ES
dc.contributor.author Alba, Miguel Angel es_ES
dc.contributor.author van der Haar, Rudolf es_ES
dc.contributor.author Cortés Barragán, Rosa Ana es_ES
dc.contributor.author Pedraz-Pingarrón, Carmen es_ES
dc.contributor.author Moreo, María Pilar es_ES
dc.contributor.author Santamariña, Carmen es_ES
dc.contributor.author Ederra, María es_ES
dc.contributor.author Vidal, Carmen es_ES
dc.contributor.author Salas-Trejo, Dolores es_ES
dc.contributor.author Llobet Azpitarte, Rafael es_ES
dc.date.accessioned 2020-11-19T04:31:28Z
dc.date.available 2020-11-19T04:31:28Z
dc.date.issued 2018-02 es_ES
dc.identifier.issn 1076-2752 es_ES
dc.identifier.uri http://hdl.handle.net/10251/155294
dc.description.abstract [EN] Objectives The association between occupational exposures and mammographic density (MD), a marker of breast cancer risk, has not been previously explored. Our objective was to investigate the influence of occupational exposure to chemical, physical and microbiological agents on MD in adult women. Methods This is a population-based cross-sectional study based on 1476 female workers aged 45-65 years from seven Spanish breast cancer screening programmes. Occupational history was surveyed by trained staff. Exposure to occupational agents was assessed using the Spanish job-exposure matrix MatEmESp. Percentage of MD was measured by two radiologists using a semiautomatic computer tool. The association was estimated using mixed log-linear regression models adjusting for age, education, body mass index, menopausal status, parity, smoking, alcohol intake, type of mammography, family history of breast cancer and hormonal therapy use, and including screening centre and professional reader as random effects terms. Results Although no association was found with most of the agents, women occupationally exposed to perchloroethylene (e(beta)=1.51; 95% CI 1.04 to 2.19), ionising radiation (e(beta)=1.23; 95% CI 0.99 to 1.52) and mould spores (e(beta)=1.44; 95% CI 1.01 to 2.04) tended to have higher MD. The percentage of density increased 12% for every 5 years exposure to perchloroethylene or mould spores, 11% for every 5 years exposure to aliphatic/alicyclic hydrocarbon solvents and 3% for each 5 years exposure to ionising radiation. Conclusions Exposure to perchloroethylene, ionising radiation, mould spores or aliphatic/alicyclic hydrocarbon solvents in occupational settings could be associated with higher MD. Further studies are needed to clarify the accuracy and the reasons for these findings. es_ES
dc.description.sponsorship This study was funded by the Spanish Ministry of Economy and Competitiveness - Carlos II Institute of Health (ISCI) (AESI PI15CI/00013); the Scientific Foundation of the Spanish Association Against Cancer (Fundacion Cientifica de la Asociacion Espanola Contra el Cancer (AEC) - EVP-1178/14); the Spanish Public Health Research Fund (FIS PI060386 & PS09/0790); the collaboration agreement between Astra-Zeneca and the ISCI (EPY1306/06) and a grant from the Spanish Federation of Breast Cancer Patients (FECMA 485 EPY 1170-10). es_ES
dc.language Inglés es_ES
dc.publisher Lippincott Williams & Wilkins es_ES
dc.relation.ispartof Journal of Occupational and Environmental Medicine es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Breast-Cancer Risk es_ES
dc.subject DDM es_ES
dc.subject Metabolites es_ES
dc.subject Mechanisms es_ES
dc.subject Solvents es_ES
dc.subject Health es_ES
dc.subject Matrix es_ES
dc.subject.classification LENGUAJES Y SISTEMAS INFORMATICOS es_ES
dc.title Occupational exposures and mammographic density in Spanish women es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1136/oemed-2017-104580 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PS09%2F0790/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI060386/ES/Determinantes de la densidad mamográfica en las mujeres participantes de los programas de detección precoz del cáncer de mama en España (DDM-Spain)/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//EPY1306%2F06/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/FECMA//485 EPY 1170-10/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/ISCIII//PI15CIII%2F0013/ES/Ocupación, exposición laboral a agentes de riesgo, condiciones de trabajo y densidad mamográfica en mujeres españolas/DDM-Ocup/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AECC//AECC%2FEVP-1178%2F14/ES/ / es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació es_ES
dc.description.bibliographicCitation Lope, V.; García-Pérez, J.; Pérez-Gómez, B.; Pedraza-Flechas, AM.; Alguacil, J.; González-Galarzo, MC.; Alba, MA.... (2018). Occupational exposures and mammographic density in Spanish women. Journal of Occupational and Environmental Medicine. 75(2):124-131. https://doi.org/10.1136/oemed-2017-104580 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1136/oemed-2017-104580 es_ES
dc.description.upvformatpinicio 124 es_ES
dc.description.upvformatpfin 131 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 75 es_ES
dc.description.issue 2 es_ES
dc.identifier.pmid 29074552 es_ES
dc.relation.pasarela S\345301 es_ES
dc.contributor.funder AstraZeneca es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Asociación Española Contra el Cáncer es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Federación Española de Cáncer de Mama es_ES
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