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Antifouling zwitterionic pSBMA-MSN particles for biomedical applications

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Antifouling zwitterionic pSBMA-MSN particles for biomedical applications

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Nombre: Beltrán-Osuna;Ród ...
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dc.contributor.author Beltrán-Osuna, A.A. es_ES
dc.contributor.author Ródenas Rochina, Joaquín es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.contributor.author Perilla-Perilla, Jairo Ernesto es_ES
dc.date.accessioned 2020-11-28T04:32:14Z
dc.date.available 2020-11-28T04:32:14Z
dc.date.issued 2019-03 es_ES
dc.identifier.issn 1042-7147 es_ES
dc.identifier.uri http://hdl.handle.net/10251/156025
dc.description.abstract [EN] Mesoporous silica nanoparticles (MSNs) are one of the most promising nanocarriers in biomedicine. Nonetheless, surface modification has been pointed out as a condition necessary for drug delivery applications, where stability and biocompatibility are extremely important for the vehicle performance. Likewise, zwitterionic polymers are outstanding candidates in biological fields, where poly(sulfobetaine methacrylate) (pSBMA) has been widely studied. These polymers, known as antifouling materials, are able to render a surface capacity to avoid protein adhesion. In this work, a core-shell nanocarrier was created, where pSBMA was covalently grafted by atom transfer radical polymerization (ATRP) onto a previously functionalized MSN surface. Brush morphologies with different chain lengths (M over bar n, between 6500 and 32 300) and graft densities (sigma(pSBMA), between 0.15 and 0.51 molecules of pSBMA per nm(2) of MSN) were obtained. Protein adhesion resistance was evaluated with two proteins: fibronectin (FN) and bovine serum albumin (BSA). The best nanocarrier synthesized allowed a reduction of 96% of FN and 76% of BSA adhesion (compared with an adsorption of 100% assigned to the native material). Since the influence of the brush morphology is seldom studied or reported, this work aims to comprehend how the configuration of the polymer brushes affected their antifouling capacity, in order to use this pSBMA-MSN product for biomedical applications, notably as a possible drug delivery nanocarrier. Future work will analyze the solution behavior of the zwitterionic brushes to evaluate variations of temperature and pH values as possible mechanisms of delivery. es_ES
dc.description.sponsorship José L. Gómez Ribelles acknowledges the support of the Ministerio de Economía y Competitividad, MINECO (research number MAT2016-76039-C4-1-R). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. This work was also supported by COLCIENCIAS (Departamento Administrativo de Ciencia Tecnología e Innovación, Convocatoria 567 Doctorados Nacionales) and Universidad Nacional de Colombia (grant number DIB 201010021438). The authors acknowledge the assistance from the Microscopy Service at the Universitat Politècnica de València where all micrographs were taken. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Polymers for Advanced Technologies es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Antifouling es_ES
dc.subject ATRP es_ES
dc.subject Drug carrier es_ES
dc.subject MSN es_ES
dc.subject Sulfobetaine methacrylate es_ES
dc.subject Zwitterionic es_ES
dc.subject.classification INGENIERIA QUIMICA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Antifouling zwitterionic pSBMA-MSN particles for biomedical applications es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/pat.4505 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UNAL//DIB 201010021438/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.description.bibliographicCitation Beltrán-Osuna, A.; Ródenas Rochina, J.; Gómez Ribelles, JL.; Perilla-Perilla, JE. (2019). Antifouling zwitterionic pSBMA-MSN particles for biomedical applications. Polymers for Advanced Technologies. 30(3):688-697. https://doi.org/10.1002/pat.4505 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/pat.4505 es_ES
dc.description.upvformatpinicio 688 es_ES
dc.description.upvformatpfin 697 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 30 es_ES
dc.description.issue 3 es_ES
dc.relation.pasarela S\404026 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder Universidad Nacional de Colombia es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Departamento Administrativo de Ciencia, Tecnología e Innovación, Colombia es_ES
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