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Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease

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Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease

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dc.contributor.author Xie, Long es_ES
dc.contributor.author Wisse, Laura E. M. es_ES
dc.contributor.author Pluta, John es_ES
dc.contributor.author de Flores, Robin es_ES
dc.contributor.author Piskin, Virgine es_ES
dc.contributor.author Manjón Herrera, José Vicente es_ES
dc.contributor.author Wang, Hongzhi es_ES
dc.contributor.author Das, Sandhitsu R. es_ES
dc.contributor.author Ding, Song-Lin es_ES
dc.contributor.author Wolk, David A. es_ES
dc.contributor.author Yushkevich, Paul A. es_ES
dc.date.accessioned 2020-12-11T04:33:52Z
dc.date.available 2020-12-11T04:33:52Z
dc.date.issued 2019-08-15 es_ES
dc.identifier.issn 1065-9471 es_ES
dc.identifier.uri http://hdl.handle.net/10251/156854
dc.description This is the peer reviewed version of the following article: Xie, L, Wisse, LEM, Pluta, J, et al. Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease. Hum Brain Mapp. 2019; 40: 3431 3451, which has been published in final form at https://doi.org/10.1002/hbm.24607. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. es_ES
dc.description.abstract [EN] Medial temporal lobe (MTL) substructures are the earliest regions affected by neurofibrillary tangle pathology-and thus are promising biomarkers for Alzheimer's disease (AD). However, automatic segmentation of the MTL using only T1-weighted (T1w) magnetic resonance imaging (MRI) is challenging due to the large anatomical variability of the MTL cortex and the confound of the dura mater, which is commonly segmented as gray matter by state-of-the-art algorithms because they have similar intensity in T1w MRI. To address these challenges, we developed a novel atlas set, consisting of 15 cognitively normal older adults and 14 patients with mild cognitive impairment with a label explicitly assigned to the dura, that can be used by the multiatlas automated pipeline (Automatic Segmentation of Hippocampal Subfields [ASHS-T1]) for the segmentation of MTL subregions, including anterior/posterior hippocampus, entorhinal cortex (ERC), Brodmann areas (BA) 35 and 36, and parahippocampal cortex on T1w MRI. Cross-validation experiments indicated good segmentation accuracy of ASHS-T1 and that the dura can be reliably separated from the cortex (6.5% mislabeled as gray matter). Conversely, FreeSurfer segmented majority of the dura mater (62.4%) as gray matter and the degree of dura mislabeling decreased with increasing disease severity. To evaluate its clinical utility, we applied the pipeline to T1w images of 663 ADNI subjects and significant volume/thickness loss is observed in BA35, ERC, and posterior hippocampus in early prodromal AD and all subregions at later stages. As such, the publicly available new atlas and ASHS-T1 could have important utility in the early diagnosis and monitoring of AD and enhancing brain-behavior studies of these regions. es_ES
dc.description.sponsorship Northern California Institute for Research and Education; Foundation for the National Institutes of Health; Canadian Institutes of Health Research; Transition Therapeutics; Takeda Pharmaceutical Company; Servier; Piramal Imaging; Pfizer Inc.; Novartis Pharmaceuticals Corporation; Neurotrack Technologies; NeuroRx Research; Meso Scale Diagnostics, LLC.; Lundbeck and Merck & Co., Inc.; Lumosity; Johnson & Johnson Pharmaceutical Research & Development LLC.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; IXICO Ltd.; GE Healthcare; Fujirebio; Genentech, Inc.; F. Hoffmann-La Roche Ltd.; EuroImmun; Eli Lilly and Company; Elan Pharmaceuticals, Inc.; Cogstate and Eisai Inc.; CereSpir, Inc.; Bristol-Myers Squibb Company; Biogen; BioClinica, Inc.; Araclon Biotech; Alzheimer's Drug Discovery Foundation; Alzheimer's Association; AbbVie; National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Department of Defense ADNI, Grant/Award Number: W81XWH-12-2-0012; Alzheimer's Disease Neuroimaging Initiative, Grant/Award Number: U01 AG024904; Spain Ministry of Economy, Industry and Competitiveness, Grant/Award Number: DPI2017-87743-R; Foundation Philippe Chatrier; BrightFocus Foundation; National Institutes of Health, Grant/Award Numbers: R01-AG055005, R01-EB017255, P30-AG010124, R01-AG040271, R01-AG056014 es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Human Brain Mapping es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Alzheimer's disease es_ES
dc.subject Anterior and posterior hippocampus es_ES
dc.subject Biomarker es_ES
dc.subject Dura mater es_ES
dc.subject Entorhinal cortex es_ES
dc.subject Mild cognitive impairment es_ES
dc.subject Perirhinal cortex es_ES
dc.subject Segmentation es_ES
dc.subject T1-weighted magnetic resonance imaging es_ES
dc.subject Transentorhinal cortex es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/hbm.24607 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//P30AG010124/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//U01AG024904/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R01EB017255/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R01AG056014/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R01AG055005/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/NIH//R01AG040271/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/DOD//W81XWH-12-2-0012/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/DPI2017-87743-R/ES/DESARROLLO DE UNA PLATAFORMA ONLINE PARA EL ANALISIS ANATOMICO DEL CEREBRO TOLERANTE A LA PRESENCIA DE ALTERACIONES PATOLOGICAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Xie, L.; Wisse, LEM.; Pluta, J.; De Flores, R.; Piskin, V.; Manjón Herrera, JV.; Wang, H.... (2019). Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease. Human Brain Mapping. 40(12):3431-3451. https://doi.org/10.1002/hbm.24607 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/hbm.24607 es_ES
dc.description.upvformatpinicio 3431 es_ES
dc.description.upvformatpfin 3451 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 40 es_ES
dc.description.issue 12 es_ES
dc.identifier.pmid 31034738 es_ES
dc.identifier.pmcid PMC6697377 es_ES
dc.relation.pasarela S\403810 es_ES
dc.contributor.funder U.S. Department of Defense es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder National Institutes of Health, EEUU es_ES
dc.contributor.funder Alzheimer's Drug Discovery Foundation es_ES
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