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dc.contributor.author | Vives-Gilabert, Yolanda | es_ES |
dc.contributor.author | Sanz-Sánchez, Jorge | es_ES |
dc.contributor.author | Molina, Pilar | es_ES |
dc.contributor.author | Cebrián Ferriols, Antonio José | es_ES |
dc.contributor.author | Igual, Begoña | es_ES |
dc.contributor.author | Calvillo-Batllés, Pilar | es_ES |
dc.contributor.author | Domingo, Diana | es_ES |
dc.contributor.author | Millet Roig, José | es_ES |
dc.contributor.author | Martínez-Dolz, Luis | es_ES |
dc.contributor.author | Castells, Francisco | es_ES |
dc.contributor.author | Zorio, Esther | es_ES |
dc.date.accessioned | 2020-12-17T04:32:22Z | |
dc.date.available | 2020-12-17T04:32:22Z | |
dc.date.issued | 2019-01-01 | es_ES |
dc.identifier.issn | 0167-5273 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10251/157274 | |
dc.description.abstract | [EN] Background: Diagnostic Task Force Criteria (TFC) for arrhythmogenic cardiomyopathy (AC) exhibit poor performance for left dominant forms. TFC only include right ventricular (RV) dysfunction (akinesia, dyssynchrony, volumes and ejection fraction). Moreover, cardiac magnetic resonance imaging (CMRI) assessment of left ventricular (LV) dyssynchrony has hitherto not been described. Thus, we aimed to comprehensively characterize LVCMRI behavior in AC patients. Methods: Thirty-five AC patients with LV involvement and twenty-three non-affected family members (controls) were enrolled. Feature-tracking analysis was applied to cine CMRI to assess LV ejection fraction (LVEF), LV end-systolic and end-diastolic volume indexes, strain values and dyssynchrony. Regions with more frequent strain and dyssynchrony impairment were also studied. Results: Radial dyssynchrony and LVEF were selected (sensitivities 54.3% and 48.6%, respectively at 100% specificity), with a threshold of 70 ms for radial dyssynchrony and 48.5% for LVEF. 71.4% of patients exceeded these thresholds (31.4% both, 22.9% only dyssynchrony and 17.1% only LVEF). Considering these cut-off values as a novel combined criterion, 30% of patients with 'borderline' or 'possible' AC following 2010 TFC would move to a 'definite' AC diagnosis. Strain was globally impaired whereas dyssynchronous regions were more often apical and located at the inferolateral wall. Conclusions: Mirroring the RV evaluation, we suggest including LVEF and LV dyssynchrony to improve the diagnosis of AC. Two independent mechanisms can be claimed in AC patients with LV involvement: 1) decreased myocardial deformation with global LV affectation and 2) delayed myocardial contraction at localized regions. | es_ES |
dc.description.sponsorship | This work was supported by grants from the "Ministerio de Economia y Competitividad" [DPI2015-70821-R], "Instituto de Salud Carlos III" and FEDER "Union Europea, Una forma de hacer Europa" [RD12/0042/0029, PI14/01477, PI18/01582 and La Fe Biobank PT17/0015/0043]. | es_ES |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | International Journal of Cardiology | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Left ventricular arrhythmogenic cardiomyopathy | es_ES |
dc.subject | Dyssynchrony | es_ES |
dc.subject | Strain | es_ES |
dc.subject | Cardiac magnetic resonance imaging | es_ES |
dc.subject | Ventricular dysfunction | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.ijcard.2018.09.024 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PI18%2F01582/ES/Modulación del fenotipo de miocardiopatía arritmogénica para mejorar el diagnóstico, buscar nuevos tratamientos y comprender sus mecanismos fisiopatogénicos. Papel de grasa epicárdica/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RD12%2F0042%2F0029/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI14%2F01477/ES/Mecanismos de enfermedad en la miocardiopatía arritmogénica, mejoras en su diagnóstico y búsqueda de dianas terapéuticas/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PT17%2F0015%2F0043/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//DPI2015-70821-R/ES/CARACTERIZACION DE LA MIOCARDIOPATIA ARRITMOGENICA A PARTIR DE TECNICAS AVANZADAS DE SEÑALES E IMAGENES PARA LA DEFINICION DE NUEVOS MARCADORES DIAGNOSTICOS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica | es_ES |
dc.description.bibliographicCitation | Vives-Gilabert, Y.; Sanz-Sánchez, J.; Molina, P.; Cebrián Ferriols, AJ.; Igual, B.; Calvillo-Batllés, P.; Domingo, D.... (2019). Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis. International Journal of Cardiology. 274:237-244. https://doi.org/10.1016/j.ijcard.2018.09.024 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.ijcard.2018.09.024 | es_ES |
dc.description.upvformatpinicio | 237 | es_ES |
dc.description.upvformatpfin | 244 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 274 | es_ES |
dc.identifier.pmid | 30228020 | es_ES |
dc.relation.pasarela | S\369836 | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |