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Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis

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Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis

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dc.contributor.author Vives-Gilabert, Yolanda es_ES
dc.contributor.author Sanz-Sánchez, Jorge es_ES
dc.contributor.author Molina, Pilar es_ES
dc.contributor.author Cebrián Ferriols, Antonio José es_ES
dc.contributor.author Igual, Begoña es_ES
dc.contributor.author Calvillo-Batllés, Pilar es_ES
dc.contributor.author Domingo, Diana es_ES
dc.contributor.author Millet Roig, José es_ES
dc.contributor.author Martínez-Dolz, Luis es_ES
dc.contributor.author Castells, Francisco es_ES
dc.contributor.author Zorio, Esther es_ES
dc.date.accessioned 2020-12-17T04:32:22Z
dc.date.available 2020-12-17T04:32:22Z
dc.date.issued 2019-01-01 es_ES
dc.identifier.issn 0167-5273 es_ES
dc.identifier.uri http://hdl.handle.net/10251/157274
dc.description.abstract [EN] Background: Diagnostic Task Force Criteria (TFC) for arrhythmogenic cardiomyopathy (AC) exhibit poor performance for left dominant forms. TFC only include right ventricular (RV) dysfunction (akinesia, dyssynchrony, volumes and ejection fraction). Moreover, cardiac magnetic resonance imaging (CMRI) assessment of left ventricular (LV) dyssynchrony has hitherto not been described. Thus, we aimed to comprehensively characterize LVCMRI behavior in AC patients. Methods: Thirty-five AC patients with LV involvement and twenty-three non-affected family members (controls) were enrolled. Feature-tracking analysis was applied to cine CMRI to assess LV ejection fraction (LVEF), LV end-systolic and end-diastolic volume indexes, strain values and dyssynchrony. Regions with more frequent strain and dyssynchrony impairment were also studied. Results: Radial dyssynchrony and LVEF were selected (sensitivities 54.3% and 48.6%, respectively at 100% specificity), with a threshold of 70 ms for radial dyssynchrony and 48.5% for LVEF. 71.4% of patients exceeded these thresholds (31.4% both, 22.9% only dyssynchrony and 17.1% only LVEF). Considering these cut-off values as a novel combined criterion, 30% of patients with 'borderline' or 'possible' AC following 2010 TFC would move to a 'definite' AC diagnosis. Strain was globally impaired whereas dyssynchronous regions were more often apical and located at the inferolateral wall. Conclusions: Mirroring the RV evaluation, we suggest including LVEF and LV dyssynchrony to improve the diagnosis of AC. Two independent mechanisms can be claimed in AC patients with LV involvement: 1) decreased myocardial deformation with global LV affectation and 2) delayed myocardial contraction at localized regions. es_ES
dc.description.sponsorship This work was supported by grants from the "Ministerio de Economia y Competitividad" [DPI2015-70821-R], "Instituto de Salud Carlos III" and FEDER "Union Europea, Una forma de hacer Europa" [RD12/0042/0029, PI14/01477, PI18/01582 and La Fe Biobank PT17/0015/0043]. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation Instituto de Salud Carlos III/PI18/01582 es_ES
dc.relation ISCIII/RD12/0042/0029 es_ES
dc.relation ISCIII/PI14/01477 es_ES
dc.relation ISCIII/PT17/0015/0043 es_ES
dc.relation info:eu-repo/grantAgreement/MINECO//DPI2015-70821-R/ES/CARACTERIZACION DE LA MIOCARDIOPATIA ARRITMOGENICA A PARTIR DE TECNICAS AVANZADAS DE SEÑALES E IMAGENES PARA LA DEFINICION DE NUEVOS MARCADORES DIAGNOSTICOS/ es_ES
dc.relation.ispartof International Journal of Cardiology es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Left ventricular arrhythmogenic cardiomyopathy es_ES
dc.subject Dyssynchrony es_ES
dc.subject Strain es_ES
dc.subject Cardiac magnetic resonance imaging es_ES
dc.subject Ventricular dysfunction es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ijcard.2018.09.024 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Vives-Gilabert, Y.; Sanz-Sánchez, J.; Molina, P.; Cebrián Ferriols, AJ.; Igual, B.; Calvillo-Batllés, P.; Domingo, D.... (2019). Left ventricular myocardial dysfunction in arrhythmogenic cardiomyopathy with left ventricular involvement: A door to improving diagnosis. International Journal of Cardiology. 274:237-244. https://doi.org/10.1016/j.ijcard.2018.09.024 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.ijcard.2018.09.024 es_ES
dc.description.upvformatpinicio 237 es_ES
dc.description.upvformatpfin 244 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 274 es_ES
dc.identifier.pmid 30228020 es_ES
dc.relation.pasarela S\369836 es_ES
dc.contributor.funder Instituto de Salud Carlos III es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Ministerio de Economía, Industria y Competitividad es_ES


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