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Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

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Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies

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Hamulic, D.; Stadler, M.; Hering, S.; Padron, JM.; Bassett, R.; Rivas, F.; Loza-Mejia, M.... (2019). Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies. Journal of Natural Products. 82(4):823-831. https://doi.org/10.1021/acs.jnatprod.8b00884

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/157357

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Title: Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies
Author: Hamulic, Damir Stadler, Marco Hering, Steffen Padron, Jose M. Bassett, Rachel Rivas, Fatima Loza-Mejia, Marco Dea-Ayuela, M. Auxiliadora González-Cardenete, Miguel A
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
[EN] The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-liquiditerpenoic acid A (abietopinoic acid) (7) along with several analogues are reported. The compounds were obtained from readily ...[+]
Subjects: Antitumor-Promoting diterpenoids , Aromatic Abietane diterpenoids , Cytotoxic activity , Molecular docking , Stem bark , In-Vitro , Derivatives , Target
Copyrigths: Reserva de todos los derechos
Source:
Journal of Natural Products. (issn: 0163-3864 )
DOI: 10.1021/acs.jnatprod.8b00884
Publisher:
American Chemical Society
Publisher version: https://doi.org/10.1021/acs.jnatprod.8b00884
Project ID:
info:eu-repo/grantAgreement/COLCIENCIAS//RC648-2017/
info:eu-repo/grantAgreement/FWF//W 1232/AU/Molecular Drug Targets/
info:eu-repo/grantAgreement/CSIC//2001680I008/
Thanks:
Financial support by the Spanish Government [Consejo Superior de Investigaciones Cientificas (2016801008)] is gratefully acknowledged. M.S. thanks the support by the doctoral program "Molecular Drug Targets" (Austrian ...[+]
Type: Artículo

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