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Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe

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Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe

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dc.contributor.author Garrido-García, Eva María es_ES
dc.contributor.author Alfonso-Navarro, María es_ES
dc.contributor.author Díaz de Greñu-Puertas, Borja es_ES
dc.contributor.author Lozano-Torres, Beatriz es_ES
dc.contributor.author Parra Álvarez, Margarita es_ES
dc.contributor.author Gaviña, Pablo es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.date.accessioned 2020-12-29T04:30:55Z
dc.date.available 2020-12-29T04:30:55Z
dc.date.issued 2020-03-02 es_ES
dc.identifier.issn 0947-6539 es_ES
dc.identifier.uri http://hdl.handle.net/10251/157915
dc.description This is the peer reviewed version of the following article: E. Garrido, M. Alfonso, B. Díaz de Greñu, B. Lozano-Torres, M. Parra, P. Gaviña, M. D. Marcos, R. Martínez-Máñez, F. Sancenón, Chem. Eur. J. 2020, 26, 2813, which has been published in final form at https://doi.org/10.1002/chem.201905688. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.description.abstract [EN] This work reports the synthesis, characterization, and sensing behavior of a hybrid nanodevice for the detection of the potent abuse drug 25I-NBOMe. The system is based on mesoporous silica nanoparticles, loaded with a fluorescent dye, functionalized with a serotonin derivative and capped with the 5-HT2A receptor antibody. In the presence of 25I-NBOMe the capping antibody is displaced, leading to pore opening and rhodamine B release. This delivery was ascribed to 5-HT2A receptor antibody detachment from the surface due to its stronger coordination with 25I-NBOMe present in the solution. The prepared nanodevice allowed the sensitive (limit of detection of 0.6 mm) and selective recognition of the 25I-NBOMe drug (cocaine, heroin, mescaline, lysergic acid diethylamide, MDMA, and morphine were unable to induce pore opening and rhodamine B release). This nanodevice acts as a highly sensitive and selective fluorometric probe for the 25I-NBOMe illicit drug in artificial saliva and in sweets. es_ES
dc.description.sponsorship The authors thank the Spanish Government (projects RTI2018-100910-B-C41 (MCUI/AEI/FEDER, UE) and CTQ2017-87954-P) and the Generalitat Valencia (PROMETEO/2018/024) for support. E.G. is grateful to the Spanish MEC for her FPU grant. The authors also thank the Electron Microscopy Service at the UPV for support. es_ES
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject 25I-NBOMe es_ES
dc.subject Agonist 5-HT2A serotonin receptor es_ES
dc.subject Hallucinogenic drugs es_ES
dc.subject Mesoporous silica nanoparticles es_ES
dc.subject Sensors es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201905688 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-87954-P/ES/NANOMAQUINAS INTELIGENTES BASADAS EN NANOMATERIALES JANUS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Garrido-García, EM.; Alfonso-Navarro, M.; Díaz De Greñu-Puertas, B.; Lozano-Torres, B.; Parra Álvarez, M.; Gaviña, P.; Marcos Martínez, MD.... (2020). Nanosensor for Sensitive Detection of the New Psychedelic Drug 25I-NBOMe. Chemistry - A European Journal. 26(13):2813-2816. https://doi.org/10.1002/chem.201905688 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/chem.201905688 es_ES
dc.description.upvformatpinicio 2813 es_ES
dc.description.upvformatpfin 2816 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 26 es_ES
dc.description.issue 13 es_ES
dc.identifier.pmid 31943443 es_ES
dc.relation.pasarela S\405197 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
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