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NEMA Performance Evaluation of CareMiBrain dedicated brain PET and Comparison with the whole-body and dedicated brain PET systems

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NEMA Performance Evaluation of CareMiBrain dedicated brain PET and Comparison with the whole-body and dedicated brain PET systems

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dc.contributor.author Moliner, Laura es_ES
dc.contributor.author Rodriguez-Alvarez, Maria J. es_ES
dc.contributor.author CATRET MASCARELL, JUAN VICENTE es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author Ilisie, Victor es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.date.accessioned 2021-02-04T04:32:07Z
dc.date.available 2021-02-04T04:32:07Z
dc.date.issued 2019-10-29 es_ES
dc.identifier.issn 2045-2322 es_ES
dc.identifier.uri http://hdl.handle.net/10251/160680
dc.description.abstract [EN] This article presents system performance studies of the CareMiBrain dedicated brain PET according to NEMA NU 2-2012 (for whole-body PETS) and NU 4-2008 (for preclinical PETs). This scanner is based on monolithic LYSO crystals coupled to silicon photomultipliers. The results obtained for both protocols are compared with current commercial whole body PETs and dedicated brain PETs found in the literature. Spatial resolution, sensitivity, NECR and scatter-fraction are characterized with NEMA standards, as well as an image quality study. A customized image quality phantom is proposed as NEMA phantoms do not fulfil the necessities of dedicated brain PETs. The full-width half maximum of the radial/tangential/ axial spatial resolution of CareMiBrain reconstructed with FBP at 10 and 100 mm from the system center were, respectively, 1.87/1.68/1.39 mm and 1.86/1.91/1.40 mm (NU 2-2012) and 1.58/1.45/1.40 mm and 1.64/1.66/1.44 mm (NU 4-2008). Peak NECR was 49 kcps@287 MBq with a scatter fraction of 48% using NU 2-2012 phantom. The sensitivity was 13.82 cps/kBq at the center of the FOV (NU 2-2012) and 10% (NU 4-2008). Contrast recovery coefficients for customizing image quality phantom were 0.73/0.78/1.14/1.01 for the 4.5/6/9/12 mm diameter rods. The performance characteristics of CareMiBrain are at the top of the current technologies for PET systems. Dedicated brain PET systems significantly improve spatial resolution and sensitivity, but present worse results in count rate measurements and scatter-fraction tests. As for the comparison of preclinical and clinical standards, the results obtained for solid and liquid sources were similar. es_ES
dc.description.sponsorship This study was funded by the Spanish Ministry of Science, Innovation and University under grant RTC-2016-5186-1, a project co-financed by the European Union through the European Regional Development Fund (ERDF). CareMiBrain system was funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 711323. Author Dr. Jose Maria Benlloch owns a small percentage of Oncovision S.A. The other authors declare no potential conflict of interest. es_ES
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject.classification INGENIERIA DE SISTEMAS Y AUTOMATICA es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title NEMA Performance Evaluation of CareMiBrain dedicated brain PET and Comparison with the whole-body and dedicated brain PET systems es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/s41598-019-51898-z es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/711323/EU/A new brain-dedicated Positron Emission Tomography (PET) system to identify β-amyloid biomarker for the early diagnosis of Alzheimer’s disease and other causes of cognitive decline/
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//RTC-2016-5186-1/ES/Control objetivo del deterioro cognitivo mediante análisis de imagen de amiloide/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2016-79884-C2-2-R/ES/DESARROLLO DEL SOFTWARE PARA SISTEMA DE DIAGNOSTICO POR IMAGEN MOLECULAR PARA CORAZON EN CONDICIONES DE STRESS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería de Sistemas y Automática - Departament d'Enginyeria de Sistemes i Automàtica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Moliner, L.; Rodriguez-Alvarez, MJ.; Catret Mascarell, JV.; González Martínez, AJ.; Ilisie, V.; Benlloch Baviera, JM. (2019). NEMA Performance Evaluation of CareMiBrain dedicated brain PET and Comparison with the whole-body and dedicated brain PET systems. Scientific Reports. 9(15484 (2019)):1-10. https://doi.org/10.1038/s41598-019-51898-z es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1038/s41598-019-51898-z es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 9 es_ES
dc.description.issue 15484 (2019) es_ES
dc.identifier.pmid 31664096 es_ES
dc.identifier.pmcid PMC6820763 es_ES
dc.relation.pasarela S\396647 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
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