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Transient UV-vis absorption spectroscopic characterisation of 2 '-methoxyacetophenone as a DNA photosensitiser

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Transient UV-vis absorption spectroscopic characterisation of 2 '-methoxyacetophenone as a DNA photosensitiser

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dc.contributor.author Rodriguez-Alzueta, Ofelia es_ES
dc.contributor.author Cuquerella Alabort, Maria Consuelo es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.date.accessioned 2021-02-06T04:33:17Z
dc.date.available 2021-02-06T04:33:17Z
dc.date.issued 2019-07-05 es_ES
dc.identifier.issn 1386-1425 es_ES
dc.identifier.uri http://hdl.handle.net/10251/160816
dc.description.abstract [EN] 2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting photosensitiser for cyclobutane pyrimidine dimers (CPDs) formation. In the present paper, a complete UV-Vis transient absorption spectroscopic characterisation of this compound is provided, including triplet-triplet spectra, triplet lifetimes and rate constants for quenching of 2M by a dimeric thymine derivative. Furthermore, generation of singlet oxygen has been proven by time-resolved near IR phosphorescence measurements. Overall, the obtained results confirm the potential of 2M as a DNA photosensitiser, not only for CPDs formation, but also for oxidative damage. es_ES
dc.description.sponsorship Financial support by the Spanish Government (O.R-A., FPU14/05294 and CTQ2015-70164-P) and Generalitat Valenciana (PROMETEO/2017/075) is gratefully acknowledged. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject DNA damage es_ES
dc.subject Nanosecond spectroscopy es_ES
dc.subject Singlet oxygen es_ES
dc.subject Triplet state es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Transient UV-vis absorption spectroscopic characterisation of 2 '-methoxyacetophenone as a DNA photosensitiser es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.saa.2019.04.007 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2015-70164-P/ES/LESIONES DEL ADN COMO FOTOSENSIBILIZADORES INTRINSECOS - CONCEPTO DE CABALLO DE TROYA/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//FPU2014-05294/ES/FPU2014-05294/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2017%2F075/ES/Reacciones fotoquímicas de biomoléculas/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química es_ES
dc.description.bibliographicCitation Rodriguez-Alzueta, O.; Cuquerella Alabort, MC.; Miranda Alonso, MÁ. (2019). Transient UV-vis absorption spectroscopic characterisation of 2 '-methoxyacetophenone as a DNA photosensitiser. Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy. 218:191-195. https://doi.org/10.1016/j.saa.2019.04.007 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.saa.2019.04.007 es_ES
dc.description.upvformatpinicio 191 es_ES
dc.description.upvformatpfin 195 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 218 es_ES
dc.identifier.pmid 30995576 es_ES
dc.relation.pasarela S\406751 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
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