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A sensitive nanosensor for the in situ detection of the cannibal drug

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A sensitive nanosensor for the in situ detection of the cannibal drug

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dc.contributor.author Garrido-García, Eva María es_ES
dc.contributor.author Alfonso-Navarro, María es_ES
dc.contributor.author Díaz de Greñu-Puertas, Borja es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Costero, Ana M. es_ES
dc.contributor.author Gil Grau, Salvador es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2021-02-19T04:33:19Z
dc.date.available 2021-02-19T04:33:19Z
dc.date.issued 2020-09-25 es_ES
dc.identifier.uri http://hdl.handle.net/10251/161838
dc.description.abstract [EN] A bio-inspired nanodevice for the selective and sensitive fluorogenic detection of 3,4- methylenedioxypyrovalerone (MDPV), usually known as Cannibal drug, is reported. The sensing nanodevice is based on mesoporous silica nanoparticles (MSNs), loaded with a fluorescent reporter (rhodamine B) and functionalized on their external surface with a dopamine derivative (3), which specifically interacts with the recombinant human dopamine transporter (DAT), capping the pores. In the presence of MDPV, DAT detaches from the MSNs consequently causing rhodamine B release and allowing drug detection. The nanosensor shows a detection limit of 5.2 µM and it is able to detect the MDPV drug both in saliva and blood plasma samples. es_ES
dc.description.sponsorship The authors thank the Spanish Government (projects RTI2018-100910-B-C41 (MCUI/AEI/FEDER, UE) and CTQ2017-87954-P) and the Generalitat Valencia (PROMETEO/2018/024) for support. E.G. is grateful to the Spanish MEC for her FPU grant. M.A. thanks her postdoctoral fellowship (PAID -10-17). The authors also thank the Electron Microscopy Service at the UPV for support. es_ES
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof ACS Sensors es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Nanosensor es_ES
dc.subject Mesoporous silica nanoparticles es_ES
dc.subject MDPV es_ES
dc.subject Cannibal drug es_ES
dc.subject Recombinant human dopamine transporter (DAT) es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.title A sensitive nanosensor for the in situ detection of the cannibal drug es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1021/acssensors.0c01553 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/UPV//PAID-10-17/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-87954-P/ES/NANOMAQUINAS INTELIGENTES BASADAS EN NANOMATERIALES JANUS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2018%2F024/ES/Sistemas avanzados de liberación controlada/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-100910-B-C41/ES/MATERIALES POROSOS INTELIGENTES MULTIFUNCIONALES Y DISPOSITIVOS ELECTRONICOS PARA LA LIBERACION DE FARMACOS, DETECCION DE DROGAS Y BIOMARCADORES Y COMUNICACION A NANOESCALA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Garrido-García, EM.; Alfonso-Navarro, M.; Díaz De Greñu-Puertas, B.; Marcos Martínez, MD.; Costero, AM.; Gil Grau, S.; Sancenón Galarza, F.... (2020). A sensitive nanosensor for the in situ detection of the cannibal drug. ACS Sensors. 5(9):2966-2972. https://doi.org/10.1021/acssensors.0c01553 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1021/acssensors.0c01553 es_ES
dc.description.upvformatpinicio 2966 es_ES
dc.description.upvformatpfin 2972 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.description.issue 9 es_ES
dc.identifier.eissn 2379-3694 es_ES
dc.identifier.pmid 32844649 es_ES
dc.relation.pasarela S\417524 es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Universitat Politècnica de València es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES
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