- -

In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC

RiuNet: Repositorio Institucional de la Universidad Politécnica de Valencia

Compartir/Enviar a

Citas

Estadísticas

  • Estadisticas de Uso

In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC

Mostrar el registro sencillo del ítem

Ficheros en el ítem

dc.contributor.author Lamprou, Efthymios es_ES
dc.contributor.author Sánchez Martínez, Filomeno es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.date.accessioned 2021-02-24T04:32:09Z
dc.date.available 2021-02-24T04:32:09Z
dc.date.issued 2020-10-11 es_ES
dc.identifier.issn 0168-9002 es_ES
dc.identifier.uri http://hdl.handle.net/10251/162256
dc.description.abstract [EN] In recent years high efforts have been devoted to enhance spatial and temporal resolutions of PET detectors. However, accurately combining these two main features is, in most of the cases, challenging. Typically, a compromise has to be made between the number of readout channels, scintillator type and size, and photosensors arrangement if aiming for a good system performance, while keeping a moderate cost. In this work, we have studied several detector configurations for PET based on a set of 8x8 Silicon Photomultiplier (SiPMs) of 3x3 mm(2) active area, and LYSO crystal arrays with different pixel sizes. An exhaustive evaluation in terms of spatial, energy and timing resolution was made for all detector configurations. In some cases, when using pixel sizes different than SiPM active area, a significant amount of scintillation light may spread among several SiPMs. Therefore, we made use of a calibration method considering the different SiPM timing contributions. Best Detector Time Resolution (DTR) of 156 ps FWHM was measured when using 3x3 mm(2) crystal pixels directly coupled to the 3x3 mm(2) SiPMs. However, when using 1.5 mm crystal pixels with the same photosensor array, although we could clearly resolve all crystal pixels, an average DTR of 250 ps FWHM was achieved. We also shed light in this work on the timing dependency of the crystal pixel and photosensor alignment. es_ES
dc.description.sponsorship This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 695536) and by the Spanish Ministerio de Economia, Industria y Competitividad under Grant TEC2016-79884-C2-1-R. The first author has also been supported by Generalitat Valenciana, Spain under grant agreement GRISOLIAP-2018-026. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject TOF-PET es_ES
dc.subject ASIC es_ES
dc.subject Time walk es_ES
dc.subject Crystal arrays es_ES
dc.subject SiPM es_ES
dc.subject Timing resolution es_ES
dc.title In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.nima.2020.164295 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//TEC2016-79884-C2-1-R/ES/DESARROLLO DEL HARDWARE PARA SISTEMA DE DIAGNOSTICO POR IMAGEN MOLECULAR PARA CORAZON EN CONDICIONES DE ESTRES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/695536/EU/Innovative PET scanner for dynamic imaging/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GRISOLIAP%2F2018%2F026/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Lamprou, E.; Sánchez Martínez, F.; Benlloch Baviera, JM.; González Martínez, AJ. (2020). In-depth evaluation of TOF-PET detectors based on crystal arrays and the TOFPET2 ASIC. Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment. 977:1-8. https://doi.org/10.1016/j.nima.2020.164295 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.nima.2020.164295 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 8 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 977 es_ES
dc.relation.pasarela S\415205 es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.description.references Jones, T., & Townsend, D. (2017). History and future technical innovation in positron emission tomography. Journal of Medical Imaging, 4(1), 011013. doi:10.1117/1.jmi.4.1.011013 es_ES
dc.description.references Surti, S. (2014). Update on Time-of-Flight PET Imaging. Journal of Nuclear Medicine, 56(1), 98-105. doi:10.2967/jnumed.114.145029 es_ES
dc.description.references Lecoq, P. (2017). Pushing the Limits in Time-of-Flight PET Imaging. IEEE Transactions on Radiation and Plasma Medical Sciences, 1(6), 473-485. doi:10.1109/trpms.2017.2756674 es_ES
dc.description.references Surti, S., & Karp, J. S. (2016). Advances in time-of-flight PET. Physica Medica, 32(1), 12-22. doi:10.1016/j.ejmp.2015.12.007 es_ES
dc.description.references Gundacker, S., Auffray, E., Pauwels, K., & Lecoq, P. (2016). Measurement of intrinsic rise times for various L(Y)SO and LuAG scintillators with a general study of prompt photons to achieve 10 ps in TOF-PET. Physics in Medicine and Biology, 61(7), 2802-2837. doi:10.1088/0031-9155/61/7/2802 es_ES
dc.description.references González-Montoro, A., Sánchez, F., Bruyndonckx, P., Cañizares, G., Benlloch, J. M., & González, A. J. (2019). Novel method to measure the intrinsic spatial resolution in PET detectors based on monolithic crystals. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 920, 58-67. doi:10.1016/j.nima.2018.12.056 es_ES
dc.description.references Moses, W. W. (2011). Fundamental limits of spatial resolution in PET. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 648, S236-S240. doi:10.1016/j.nima.2010.11.092 es_ES
dc.description.references Lamprou, E., Gonzalez, A. J., Sanchez, F., & Benlloch, J. M. (2020). Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs. Physica Medica, 70, 10-18. doi:10.1016/j.ejmp.2019.12.004 es_ES
dc.description.references Lamprou, E., Aguilar, A., González-Montoro, A., Monzó, J. M., Cañizares, G., Iranzo, S., … Benlloch, J. M. (2018). PET detector block with accurate 4D capabilities. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 912, 132-136. doi:10.1016/j.nima.2017.11.002 es_ES
dc.description.references A. Di Francesco, R. Bugalho, L. Oliveira, L. Pacher, A. Rivetti, M. Rolo, et al. TOFPET2: A high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications, J. Instrum. 11 (03) C03042. es_ES
dc.description.references Van Dam, H. T., Borghi, G., Seifert, S., & Schaart, D. R. (2013). Sub-200 ps CRT in monolithic scintillator PET detectors using digital SiPM arrays and maximum likelihood interaction time estimation. Physics in Medicine and Biology, 58(10), 3243-3257. doi:10.1088/0031-9155/58/10/3243 es_ES
dc.description.references V. Nadig, D. Schug, B. Weissler, V. Schulz, Evaluation Of The PETsys TOFPET2 ASIC In Multi-Channel Coincidence Experiments, arXiv:1911.08156. es_ES
dc.description.references Gundacker, S., Turtos, R. M., Auffray, E., Paganoni, M., & Lecoq, P. (2019). High-frequency SiPM readout advances measured coincidence time resolution limits in TOF-PET. Physics in Medicine & Biology, 64(5), 055012. doi:10.1088/1361-6560/aafd52 es_ES
dc.description.references Gundacker, S., Acerbi, F., Auffray, E., Ferri, A., Gola, A., Nemallapudi, M. V., … Lecoq, P. (2016). State of the art timing in TOF-PET detectors with LuAG, GAGG and L(Y)SO scintillators of various sizes coupled to FBK-SiPMs. Journal of Instrumentation, 11(08), P08008-P08008. doi:10.1088/1748-0221/11/08/p08008 es_ES


Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem