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Impact of embryo technologies on secondary sex ratio in rabbit

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Impact of embryo technologies on secondary sex ratio in rabbit

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dc.contributor.author Garcia-Dominguez, X es_ES
dc.contributor.author Juarez, Jorge D. es_ES
dc.contributor.author Vicente Antón, José Salvador es_ES
dc.contributor.author Marco-Jiménez, Francisco es_ES
dc.date.accessioned 2021-04-23T03:31:52Z
dc.date.available 2021-04-23T03:31:52Z
dc.date.issued 2020-12 es_ES
dc.identifier.issn 0011-2240 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165523
dc.description.abstract [EN] Increasing evidence indicates that assisted reproductive technologies (ARTs) disturb skewed sex-ratio and induce sex-dimorphic postnatal effects. Undoubtedly, the combination of multiple ovulation and embryo transfer (MOET) together with the use of vitrification technique (MOVET) is currently being used in breeding programs. However, since the first case of sex skewing reported in 1991, the accumulative and long-term transmission of skewed sex-ratio to future generations has not been thoroughly evaluated. Here we test as MOVET program induce a skewed sex ratio, and we consider skewed sex ratio transmission to future generations. To this end, we first evaluated the F1 generation, demonstrating that a MOVET program causes a severe imbalance skewed secondary sex ratio (SSR) towards male by 12%. This imbalanced persist after a second MOVET program (F2 generation), with an accumulative skewed SSR towards male by 25%. Finally, using a crossbred generation derived from crossing F1 males derived from a MOVET program with naturally-conceived (NC) females, we show that the imbalance skewed SRR persist. Bodyweight comparison between MOVET animals and NC counterparts revealed significant changes at birth, weaning and adulthood. However, there was a significant interaction between F2 MOVET animals and sex, demonstrating an apparent accumulative sex-dimorphic effect. At adulthood, MOVET derived males presented a lower body weight. In conclusion, we show that the MOVET program causes a direct, accumulative and long-term transmission of skewed SSR. es_ES
dc.description.sponsorship This work was supported by the Ministry of Economy, Industry and Competitiveness (Research project: AGL2017-85162-C2-1-R) is acknowledged. X. Garcia-Dominguez was supported by a research grant from the Ministry of Economy, Industry and Competitiveness (BES-2015-072429). English text version was revised by N. Macowan English Language Service. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Cryobiology es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject MOET es_ES
dc.subject Superovulation es_ES
dc.subject Vitrification es_ES
dc.subject Embryo transfer es_ES
dc.subject Sex es_ES
dc.subject Dimorphic es_ES
dc.subject.classification BIOLOGIA ANIMAL es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Impact of embryo technologies on secondary sex ratio in rabbit es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.cryobiol.2020.10.008 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BES-2015-072429/ES/BES-2015-072429/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2017-85162-C2-1-R/ES/MEJORA GENETICA DEL CONEJO DE CARNE: ESTRATEGIAS PARA INCREMENTAR LA EFICACIA DE LA MEJORA, REPRODUCCION Y SALUD DE LINEAS PATERNALES/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Garcia-Dominguez, X.; Juarez, JD.; Vicente Antón, JS.; Marco-Jiménez, F. (2020). Impact of embryo technologies on secondary sex ratio in rabbit. Cryobiology. 97:60-65. https://doi.org/10.1016/j.cryobiol.2020.10.008 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1016/j.cryobiol.2020.10.008 es_ES
dc.description.upvformatpinicio 60 es_ES
dc.description.upvformatpfin 65 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 97 es_ES
dc.identifier.pmid 33053364 es_ES
dc.relation.pasarela S\424926 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder Ministerio de Economía y Empresa es_ES
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