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Regenerative and resorbable PLA/HA hybrid construct for tendon/ligament tissue engineering

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Regenerative and resorbable PLA/HA hybrid construct for tendon/ligament tissue engineering

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dc.contributor.author Araque-Monrós, M. C. es_ES
dc.contributor.author García-Cruz, D. M. es_ES
dc.contributor.author Escobar-Ivirico, J. L. es_ES
dc.contributor.author Gil-Santos, L. es_ES
dc.contributor.author Monleón Pradas, Manuel es_ES
dc.contributor.author Más Estellés, Jorge es_ES
dc.date.accessioned 2021-04-29T03:31:42Z
dc.date.available 2021-04-29T03:31:42Z
dc.date.issued 2020-02 es_ES
dc.identifier.issn 0090-6964 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165759
dc.description.abstract [EN] Tendon and ligament shows extremely limited endogenous regenerative capacity. Current treatments are based on the replacement and or augmentation of the injured tissue but the repaired tissue rarely achieve functionality equal to that of the preinjured tissue. To address this challenge, tissue engineering has emerged as a promising strategy. This study develops a regenerative and resorbable hybrid construct for tendon and ligament engineering. The construct is made up by a hollow poly-lactic acid braid with embedded microspheres carrying cells and an anti-adherent coating, with all the parts being made of biodegradable materials. This assembly intends to regenerate the tissue starting from the interior of the construct towards outside while it degrades. Fibroblasts cultured on poly lactic acid and hyaluronic acid microspheres for 6 h were injected into the hollow braid and the construct was cultured for 14 days. The cells thus transported into the lumen of the construct were able to migrate and adhere to the braid fibers naturally, leading to a homogeneous proliferation inside the braid. Moreover, no cells were found on the outer surface of the coating. Altogether, this study demonstrated that PLA/HA hybrid construct could be a promising material for tendon and ligament repair. es_ES
dc.description.sponsorship This work was supported by AITEX (Textil Research Institute, Alcoi, Alicante, Spain) through the researching contract "Development of braided biomaterials for biomedical applications'' and also funded by AEI "RTI2018-095872-B-C21 and C22/ERDF''. es_ES
dc.language Inglés es_ES
dc.publisher Springer-Verlag es_ES
dc.relation.ispartof Annals of Biomedical Engineering es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Regeneration es_ES
dc.subject Braid scaffolds es_ES
dc.subject Microspheres es_ES
dc.subject Fibroblasts es_ES
dc.subject Coating es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.title Regenerative and resorbable PLA/HA hybrid construct for tendon/ligament tissue engineering es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10439-019-02403-0 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095872-B-C21/ES/NUEVO BIOMATERIAL BIO-ACTIVO PARA LA REGENERACION DE LESIONES MEDULARES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095872-B-C22/ES/NUEVO DISPOSITIVO BIOACTIVO PARA LA REGENERACION DE LESIONES DE LA MEDULA ESPINAL./ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada es_ES
dc.description.bibliographicCitation Araque-Monrós, MC.; García-Cruz, DM.; Escobar-Ivirico, JL.; Gil-Santos, L.; Monleón Pradas, M.; Más Estellés, J. (2020). Regenerative and resorbable PLA/HA hybrid construct for tendon/ligament tissue engineering. Annals of Biomedical Engineering. 48(2):757-767. https://doi.org/10.1007/s10439-019-02403-0 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1007/s10439-019-02403-0 es_ES
dc.description.upvformatpinicio 757 es_ES
dc.description.upvformatpfin 767 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 48 es_ES
dc.description.issue 2 es_ES
dc.identifier.pmid 31705364 es_ES
dc.relation.pasarela S\400295 es_ES
dc.contributor.funder Agencia Estatal de Investigación es_ES
dc.contributor.funder European Regional Development Fund es_ES
dc.contributor.funder Asociación de Investigación de la Industria Textil es_ES
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