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Molecular networks of insulin signaling and amino acid metabolism in subcutaneous adipose tissue are altered by body condition in periparturient Holstein cows

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Molecular networks of insulin signaling and amino acid metabolism in subcutaneous adipose tissue are altered by body condition in periparturient Holstein cows

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dc.contributor.author Liang, Y. es_ES
dc.contributor.author Alharthi, A.S. es_ES
dc.contributor.author Elolimy, A.A. es_ES
dc.contributor.author Bucktrout, R. es_ES
dc.contributor.author Lopreiato, V. es_ES
dc.contributor.author Cortes, I. es_ES
dc.contributor.author Xu, C. es_ES
dc.contributor.author Fernández Martínez, Carlos Javier es_ES
dc.contributor.author Trevisi, E. es_ES
dc.contributor.author Loor, J.J. es_ES
dc.date.accessioned 2021-04-30T03:31:38Z
dc.date.available 2021-04-30T03:31:38Z
dc.date.issued 2020-11 es_ES
dc.identifier.issn 0022-0302 es_ES
dc.identifier.uri http://hdl.handle.net/10251/165802
dc.description.abstract [EN] Peripartal cows mobilize not only body fat but also body protein to satisfy their energy requirements. The objective of this study was to determine the effect of prepartum BCS on blood biomarkers related to energy and nitrogen metabolism, and mRNA and protein abundance associated with AA metabolism and insulin signaling in subcutaneous adipose tissue (SAT) in peripartal cows. Twenty-two multiparous Holstein cows were retrospectively classified into a high BCS (HBCS; n = 11, BCS >= 3.5) or normal BCS (NBCS; n = 11, BCS <= 3.17) group at d 28 before expected parturition. Cows were fed the same diet as a total mixed ration before parturition and were fed the same lactation diet postpartum. Blood samples collected at -10, 7, 15, and 30 d relative to parturition were used for analyses of biomarkers associated with energy and nitrogen metabolism. Biopsies of SAT harvested at -15, 7, and 30 d relative to parturition were used for mRNA (real timePCR) and protein abundance (Western blotting) assays. Data were subjected to ANOVA using the MIXED procedure of SAS (v. 9.4; SAS institute Inc., Cary, NC), with P <= 0.05 being the threshold for significance. Cows in HBCS had greater overall plasma nonesterified fatty acid concentrations, due to marked increases at 7 and 15 d postpartum. This response was similar (BCS x Day effect) to protein abundance of phosphorylated (p) protein kinase B (p-AKT), the insulin-induced glucose transporter (SLC2A4), and the sodium-coupled neutral AA transporter (SLC38A1). Abundance of these proteins was lower at -15 d compared with NBCS cows, and either increased (SLC2A4, SLC38A1) or did not change (p-AKT) at 7 d postpartum in IIBCS. Unlike protein abundance, however, overall mRNA abundances of the high-affinity cationic (SLC7A1), proton-coupled (SLC96A1), and sodium-coupled amino acid transporters (SLC,98,42) were greater in IIBCS than NBCS cows, due to upregulation in the postpartum phase. Those responses were similar to protein abundance of p-mTOR, which increased (BCS x Day effect) at 7 d in HBCS compared with NBCS cows. mRNA abundance of argininosuccinate lyase (ASL) and arginase 1 (ARG1) also was greater overall in HBCS cows. Together, these responses suggested impaired insulin signaling, coupled with greater postpartum AA transport rate and urea cycle activity in SAT of HBCS cows. An in vitro study using adipocyte and macrophage cocultures stimulated with various concentrations of fatty acids could provide some insights into the role of immune cells in modulating adipose tissue immunometabolic status, including insulin resistance and AA metabolism. es_ES
dc.description.sponsorship Y. Liang is a recipient of a doctoral fellowship from the China Scholarship Council (CSC, Beijing, China) to perform his PhD studies at the University of Illinois (Urbana). A. S. Alharthi received a fellowship from King Saud University (Riyadh, Saudi Arabia) to perform his PhD studies at the University of Illinois (Urbana). A. A. Elolimy was recipient of a fellowship from the Higher Education Ministry (Cairo, Egypt) to perform his PhD studies at the University of Illinois (Urbana). We thank Perdue AgriBusiness (Salisbury, MD) for the donation of ProvAAL2 AADvantage during the course of the experiment. The authors declare no conflicts of interest. es_ES
dc.language Inglés es_ES
dc.publisher American Dairy Science Association es_ES
dc.relation.ispartof Journal of Dairy Science es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Body condition es_ES
dc.subject Amino acid transporter es_ES
dc.subject Urea cycle es_ES
dc.subject Insulin resistance es_ES
dc.subject Subcutaneous adipose tissue es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Molecular networks of insulin signaling and amino acid metabolism in subcutaneous adipose tissue are altered by body condition in periparturient Holstein cows es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.3168/jds.2020-18612 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.description.bibliographicCitation Liang, Y.; Alharthi, A.; Elolimy, A.; Bucktrout, R.; Lopreiato, V.; Cortes, I.; Xu, C.... (2020). Molecular networks of insulin signaling and amino acid metabolism in subcutaneous adipose tissue are altered by body condition in periparturient Holstein cows. Journal of Dairy Science. 103(11):10459-10476. https://doi.org/10.3168/jds.2020-18612 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.3168/jds.2020-18612 es_ES
dc.description.upvformatpinicio 10459 es_ES
dc.description.upvformatpfin 10476 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 103 es_ES
dc.description.issue 11 es_ES
dc.identifier.pmid 32921465 es_ES
dc.relation.pasarela S\430254 es_ES
dc.contributor.funder China Scholarship Council es_ES
dc.contributor.funder King Saud University, Arabia Saudí es_ES
dc.contributor.funder Egyptian Ministry of Higher Education es_ES
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